業　績

福田　伊津子

 

I 著書

(1) 福田伊津子, 芦田均. 「抗環境汚染物質毒性」　茶の事典, 大森正司,阿南豊正,伊勢村護,加藤みゆき,滝口明子,中村羊一郎編, 朝倉書店, (印刷中).

(2) Itsuko Fukuda and Hitoshi Ashida.  Modulation of drug-metabolizing enzymes and transporters by polyphenols as one of the anti-carcinogenic effects.  In: Polyphenols in Human Health and Diseases: Vol. 2, Ronald Ross Watson, Victor R. Preedy, and Sherma Zibadi, eds., Chapter 86, pp. 1127-1135 (2013).

(3) 川瀬雅也，芦田均，福田伊津子．「熱中性子放射化分析による定量分析」　メタルバイオテクノロジーによる環境保全と資源回収　〜新元素戦略の新しいキーテクノロジー〜，第7章2，日本生物工学会メタルバイオ部会，シーエムシー出版，東京，pp. 263-270 (2009)．

(4) Itsuko Fukuda and Hitoshi Ashida.  Suppressive effects of flavonoids on activation of the aryl hydrocarbon receptor induced by dioxins.  In: Functional Food and Health, T. Shibamoto, K. Kanazawa, F. Shahidi, and C.-T. Ho, eds., American Chemical Society, Washington, DC, pp. 369-374 (2008).

(5) 福田伊津子, 芦田均. 「芳香族炭化水素の毒性発現抑制作用への可能性」 茶の効能と応用開発, 伊勢村護監修, シーエムシー出版, 東京, pp. 316-326 (2006).

(6) Itsuko Fukuda. Studies on suppression of dioxin toxicity by food factors.  Doctorial Dissertation, (2004).

(7)-1 Itsuko Fukuda, Atsushi Kaneko, Yoshiyuki Yabushita, Iwao Sakane, Takami Kakuda, Kazuki Kanazawa, Gen-ichi Danno, and Hitoshi Ashida. Green tea extracts prevent the dioxin toxicity through the suppression of transformation of the aryl hydrocarbon receptor.  In: Food Factors in Health Promotion and Disease Prevention, F. Shahidi, C.-T. Ho, S. Watanabe, and T. Osawa, eds., American Chemical Society, Washington, DC, pp. 119-127 (2003).

(7)-2 Hitoshi Ashida, Takashi Hashimoto, Yuji Nonaka, Itsuko Fukuda, Kazuki Kanazawa, Gen-ichi Danno, Ken-ichiro Minato, Sachiko Kawakami, and Masashi Mizuno. Suppression of cytochrome P4501A subfamily in mouse liver by oral intake of polysaccharides from mushrooms, Lentinus edodes and Agaricus blazei. In: Food Factors in Health Promotion and Disease Prevention, F. Shahidi, C.-T. Ho, S. Watanabe, and T. Osawa, eds., American Chemical Society, Washington, DC, pp. 235-248 (2003).

 

II　総説

(1) Hitoshi Ashida, Shin Nishiumi, and Itsuko Fukuda.  An update on the dietary ligands of the AhR.  Expert Opinion on Drug Metabolism & Toxicology, 4(11), 1429-1447 (2008).

(2) 福田伊津子，芦田均．「ダイオキシン類の生物学的超微量測定法」　検査技術，13(8)，pp 15-20 (2008)．

(3) 福田伊津子, 芦田均. 「カテキンのダイオキシン毒性予防作用」 生物工学会誌, 82(10), pp.477-480 (2004).

 

III　論文

(1) Itsuko Fukuda, Shin Nishiumi, Rie Mukai, Ken-ichi Yoshida, and Hitoshi Ashida.  Catechins in tea suppress the activity of cytochrome P450 1A1 through the aryl hydrocarbon receptor activation pathway in rat livers.  International Journal of Food Sciences and Nutrition, in press (doi:10.3109/09637486.2014.992007).

(2) Itsuko Fukuda and Hitoshi Ashida.  Application of a southwestern-chemistry based ELISA to evaluation of dioxins in the farm products.  Organohalogen Compounds, 74, 173-176 (2012).
(3) Ayano Nomura, Masaki Kinehara, Itsuko Fukuda, and Hitoshi Ashida.  Induction of the multidrug-resistant Mdr1b mediated by aryl hydrocarbon receptor in mouse hepatoma Hepa-1c1c7 cells.  Organohalogen Compounds, 74, 1005-1008 (2012).
(4) Masaya Kawase, Tadashi Saito, Teruo Yasunaga, Tatsuya Takagi, Itsuko Fukuda, and Hitoshi Ashida.  New structure descriptor in structure-activity relationship study in the suppression of the aryl hydrocarbon receptor transformation by anthraquinones.  Food Science and Technology Research, 18, 173-176 (2012).
(5) Itsuko Fukuda, Miki Tsutsui, Tadashi Yoshida, Toshiya Toda, Takanori Tsuda, and Hitoshi Ashida.  Oral toxicological studies of black soybean (Glycine max) hull extract: Acute studies in rats and mice, and chronic studies in mice.  Food and Chemical Toxicology, 49, 3272-3278 (2011).
(6) Yuki Kanamoto, Yoko Yamashita, Fumio Nanba, Tadashi Yoshida, Takanori Tsuda, Itsuko Fukuda, Sachiko Nakamura-Tsuruta, and Hitoshi Ashida.  A black soybean seed coat extract prevents obesity and glucose intolerance by up-regulating uncoupling proteins and down-regulating inflammatory cytokines in high-fat diet-fed mice.  Journal of Agricultural and Food Chemistry, 59, 8985-8993 (2011).

(7) Norio Yamamoto, Yuki Kanamoto, Manabu Ueda, Kengo Kawasaki, Itsuko Fukuda, and Hitoshi Ashida.  Anti-obese and anti-diabetic effects of ethanol extract of Artemisia princeps in C57BL/6 mice fed a high-fat diet.  Food and Function, 2, 45-52 (2011).

(8) Takashi Furuyashiki, Hiroki Takata, Iwao Kojima, Takashi Kuriki, Itsuko Fukuda, and Hitoshi Ashida.  Matabolic fate of orally administered enzymatically synthesized glycogen in rats.  Food and Function, 2, 183-189 (2011).

(9) Norio Yamamoto, Kyuichi Kawabata, Keisuke Sawada, Manabu Ueda, Itsuko Fukuda, Kengo Kawasaki, Akira Murakami, and Hitoshi Ashida.  Cardamonin stimulates glucose uptake through translocation of glucose transporter-4 in L6 myotubes.  Phytotherapy Research, 25, 1218-1224 (2011).

(10) Rie Mukai, Yasuhito Shirai, Naoaki Saito, Itsuko Fukuda, Shin Nishiumi, Ken-ichi Yoshida, and Hitoshi Ashida.  Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction.  Archives of Biochemistry and Biophysics, 501, 134-141 (2010).

(11) Manabu Ueda, Takashi Furuyashiki, Kayo Yamada, Yukiko Aoki, Itsuko Fukuda, Ken-ichi Yoshida, and Hitoshi Ashida.  Tea catechins modulate translocation of the glucose transporter 4 in 3T3-L1 adipocytes.  Food and Function, 1(2), 167-173 (2010).

(12) 福田伊津子，小土井理恵，久保麻友子，藤嶽暢英，藤田剛，芦田均．パン酵母β-グルカン摂取によるラットの盲腸内容物および糞便排泄に及ぼす影響．生物工学会誌，87(4)，170-174 (2009)．

(13) 福田伊津子，小土井理恵，久保麻友子，岡本隆志，藤田剛，芦田均．パン酵母β-グルカンのラットにおける脂質異常症予防効果．生物工学会誌，87(3)，129-134 (2009)．

(14) Masaki Kinehara, Itsuko Fukuda, Ken-ichi Yoshida, and Hitoshi Ashida.  Aryl hydrocarbon receptor-mediated induction of the cytosolic phospholipase A2a gene by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse hepatoma Hepa-1c1c7 cells.  Journal of Bioscience and Bioengineering, 108(4), 277-281 (2009).

(15) Itsuko Fukuda, Miki Tsutsui, Iwao Sakane, and Hitoshi Ashida.  Suppression of cytochrome P450 1A1 expression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse hepatoma Hepa-1c1c7 cells treated with serum of (−)-epigallocatechin-3-gallate- and green tea extract-administered rats.  Bioscience Biotechnology and Biochemistry, 73(5), 1206-1208 (2009).

(16) Itsuko Fukuda, Atsushi Kaneko, Shin Nishiumi, Masaya Kawase, Rika Nishikiori, Nobuhide Fujitake, and Hitoshi Ashida.  Structure-activity relationships of anthraquinones on the suppression of DNA-binding activity of the aryl hydrocarbon receptor induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.  Journal of Bioscience and Bioengineering, 107(3), 296-300 (2009).

(17) Masaki Kinehara, Itsuko Fukuda, Ken-ichi Yoshida, and Hitoshi Ashida.  High-throughput evaluation of aryl hydrocarbon receptor-binding sites selected via chromatin immunoprecipitation-based screening in Hepa-1c1c7 cells stimulated with 2,3,7,8-tetrachlorodibenzo-p-dioxin.  Genes & Genetic Systems, 83(6), 455-468 (2008).

(18) Rie Mukai, Itsuko Fukuda, Shin Nishiumi, Midori Natsume, Naomi Osakabe, Ken-ichi Yoshida, and Hitoshi Ashida.  Cacao polyphenol extract suppresses transformation of an aryl hydrocarbon receptor in C57BL/6 mice.  Journal of Agricultural and Food Chemistry, 56(21), 10399-10405 (2008).

(19) Manabu Ueda, Shin Nishiumi, Hironobu Nagayasu, Itsuko Fukuda, Ken-ichi Yoshida, and Hitoshi Ashida.  Epigallocatechin gallate promotes GLUT4 translocation in skeletal muscle.  Biochemical and Biophysical Research Communications, 377(1), 286-290 (2008).

(20) Daisuke Kashiwada, Itsuko Fukuda, Ken-ichi Yoshida, and Hitoshi Ashida.  Suppressive effects of propolis extract on cytochrome P4501A1 expression induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.  Journal of Clinical Biochemistry and Nutrition, 43(Suppl.1), 460-463 (2008).

(21) Tomohiro Ohno, Hironori Tomi, Shin Nishiumi, Itsuko Fukuda, and Hitoshi Ashida.  Effect of chamomile extract on adiposity in mice fed a high-fat diet.  Journal of Clinical Biochemistry and Nutrition, 43(Suppl.1), 243-246 (2008).

(22) Shin Nishiumi, Yoshiyuki Yabushita, Takashi Furuyashiki, Itsuko Fukuda, and Hitoshi Ashida.  Involvement of SREBPs in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced disruption of lipid metabolism in male guinea pig.  Toxicology and Applied Pharmacology, 229(3), 281-289 (2008).

(23) Shin Nishiumi, Norio Yamamoto, Rie Kodoi, Itsuko Fukuda, Ken-ichi Yoshida, and Hitoshi Ashida.  Antagonistic and agonistic effects of indigoids on the transformation of an aryl hydrocarbon receptor.  Archives of Biochemistry and Biophysics, 470(2), 187-199 (2008).

(24) Rie Sasaki, Natsumi Nishimura, Hiromi Hoshino, Yasuka Isa, Maho Kadowaki, Takahito Ichi, Akihito Tanaka, Shin Nishiumi, Itsuko Fukuda, Hitoshi Ashida, Fumihiko Horio, and Takanori Tsuda.  Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice.  Biochemical Pharmacology, 74(11), 1619-1627 (2007).

(25) Itsuko Fukuda, Rie Mukai, Masaya Kawase, Ken-ichi Yoshida, and Hitoshi Ashida.  Interaction between the aryl hydrocarbon receptor and its antagonists, flavonoids.  Biochemical and Biophysical Research Communications, 359(3) 822-827 (2007).

(26) Mika Hamada, Hideo Satsu, Yayoi Natsume, Shin Nishiumi, Itsuko Fukuda, Hitoshi Ashida, and Makoto Shimizu.  TCDD-induced CYP1A1 expression, and index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers.  Journal of Agricultural and Food Chemistry, 54(23), 8891-8898 (2006).

(27) Itsuko Fukuda, Sayaka Terashima, and Hitoshi Ashida.  (+)-Catechin suppresses the inhibition of 3T3-L1 differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.  ITE Letters on Batteries, New Technologies & Medicine, 7(3), 292-295 (2006).

(28) Hiroyuki Sakakibara, Hitoshi Ashida, Itsuko Fukuda, Takashi Furuyashiki, Takashi Sano, Yuji Nonaka, Takashi Hashimoto, and Kazuki Kanazawa.  A frequent drinking of green tea lowers the levels of endogenous oxidative stress in small intestines, erythrocytes and kidneys in rats.  Journal of Clinical Biochemistry and Nutrition, 39(1), 32-39 (2006).

(29) Shin Nishiumi, Yoshiyuki Yabushita, Itsuko Fukuda, Rie Mukai, Ken-ichi Yoshida, and Hitoshi Ashida.  Molokhia (Corchorus olitorius L.) extract suppresses transformation of the aryl hydrocarbon receptor induced by dioxins.  Food and Chemical Toxicology, 44(2), 250-260 (2006).

(30) Shin Nishiumi, Keizo Hosokawa, Rie Mukai, Itsuko Fukuda, Atsuyuki Hishida, Osamu Iida, Ken-ichi Yoshida, and Hitoshi Ashida.  Screening of the indigenous plants from Japan for modulating effects on transformation of the aryl hydrocarbon receptor.  Asian Pacific Journal of Cancer Prevention, 7(2), 208-220 (2006).

(31) Yong K Park, Itsuko Fukuda, Hitoshi Ashida, Shin Nishiumi, Ken-ichi Yoshida, Andreas Daugsch, Helia H. Sato, and Glaucia M. Pastore.  Suppressive effects of ethanolic extracts from propolis and its main botanical origin on dioxin toxicity.  Journal of Agricultural and Food Chemistry, 53(26), 10306-10309 (2005).

(32) Yoshiyuki Yabushita, Itsuko Fukuda, Shin Nishiumi, and Hitoshi Ashida.  Suppressive effects of commercial beverages on TCDD-induced aryl hydrocarbon receptor transformation.  ITE Letters on Batteries, New Technologies & Medicine, 6(4), 372-377 (2005).

(33) Itsuko Fukuda, Iwao Sakane, Yoshiyuki Yabushita, Shin-ichi Sawamura, Kazuki Kanazawa, and Hitoshi Ashida.  Black tea theaflavins suppress dioxin-induced transformation of the aryl hydrocarbon receptor.  Bioscience Biotechnology and Biochemistry, 69(5), 883-890 (2005).

(34) Rie Mukai, Itsuko Fukuda, Keizo Hosokawa, Shin Nishiumi, Atsushi Kaneko, and Hitoshi Ashida.  Anthocyans fail to suppress transformation of aryl hydrocarbon receptor induced by dioxin.  Bioscience Biotechnology and Biochemistry, 69(5), 896-903 (2005).

(35) Itsuko Fukuda, Iwao Sakane, Yoshiyuki Yabushita, Shin-ichi Sawamura, Kazuki Kanazawa, and Hitoshi Ashida.  Black tea extract suppresses transformation of aryl hydrocarbon receptor induced by dioxin.  BioFactors, 21(1-4), 367-369 (2004).

(36) Rie Mukai, Itsuko Fukuda, Shin Nishiumi, Keizo Hosokawa, Kazuki Kanazawa, and Hitoshi Ashida.  Anthocyan does not suppress transformation of aryl hydrocarbon receptor induced by dioxin.  BioFactors, 21(1-4), 371-373 (2004).

(37) Takashi Okamoto, Rie Kodoi, Yuji Nonaka, Itsuko Fukuda, Takashi Hashimoto, Kazuki Kanazawa, Masashi Mizuno, and Hitoshi Ashida.  Lentinan from shiitake mushroom (Lentinus edodes) suppresses expression of cytochrome P4501A subfamily in the mouse liver.  BioFactors, 21(1-4), 407-409 (2004).

(38) Itsuko Fukuda, Iwao Sakane, Yoshiyuki Yabushita, Rie Kodoi, Shin Nishiumi, Takami Kakuda, Shin-ichi Sawamura, Kazuki Kanazawa, and Hitoshi Ashida.  Pigments in green tea leaves (Camellia sinensis) suppress transformation of the aryl hydrocarbon receptor induced by dioxin.  Journal of Agricultural and Food Chemistry, 52(9), 2499-2506 (2004).

(39) Yong K. Park, Itsuko Fukuda, Hitoshi Ashida, Shin Nishiumi, Julio P.-Guzman, Helia H. Sato, and Glaucia M. Pastore.  Suppression of dioxin mediated aryl hydrocarbon receptor transformation by ethanolic extracts of propolis.  Bioscience Biotechnology and Biochemistry, 68(4), 935-938 (2004).

(40) Itsuko Fukuda, Shin Nishiumi, Yoshiyuki Yabushita, Rie Mukai, Rie Kodoi, Kaoru Hashizume, Masashi Mizuno, Yutaka Hatanaka, and Hitoshi Ashida.  A new southwestern chemistry-based ELISA for detection of aryl hydrocarbon receptor transformation: application to the screening of its receptor agonists and antagonists.  Journal of Immunological Methods, 287(1-2), 187-201 (2004).

(41) Kaoru Hashizume, Yutaka Hatanaka, Itsuko Fukuda, Takashi Sano, Yukihiro Yamaguchi, Yoichi Tani, Gen-ichi Danno, Keiichiro Suzuki, and Hitoshi Ashida.  N-Acetyl-L-cysteine suppresses constitutive expression of CD11a/LFA-1a protein in myeloid lineage.  Leukemia Research, 26(10), 939-944 (2002).

(42) Takashi Hashimoto, Takashi Furuyashiki, Takashi Sano, Kaori Kihara, Itsuko Fukuda, Wakana Ito, Pyoyun Park, Kazuki Kanazawa, Gen-ichi Danno, and Hitoshi Ashida.  Apoptosis in the thymus after intraperitoneal injection of rats with Trp-P-1.  Environmental and Molecular Mutagenesis, 40(3), 175-183 (2002).

(43) Yutaka Hatanaka, Hitoshi Ashida, Kaoru Hashizume, Itsuko Fukuda, Takashi Sano, Yukihiro Yamaguchi, Takeshi Endo, Yoichi Tani, Keiichiro Suzuki, and Gen-ichi Danno.  Up-regulation of CD13/aminopeptidase N induced by phorbol ester is involved in redox regulation and tumor necrosis factor a production in HL-60 cells.  Inflammation, 26(4), 175-181 (2002).

(44) Takashi Hashimoto, Yuji Nonaka, Ken-ichiro Minato, Sachiko Kawakami, Masashi Mizuno, Itsuko Fukuda, Kazuki Kanazawa, and Hitoshi Ashida.  Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice.  Bioscience Biotechnology and Biochemistry, 66(7), 1610-1614 (2002).

(45) Hitoshi Ashida, Kaori Kihara, Yuji Nonaka, Itsuko Fukuda, Bunsyo Shiotani, and Takashi Hashimoto.  The heterocyclic amine, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole induces apoptosis in cocultures of rat parenchymal and nonparenchymal liver cells.  Toxicology and Applied Pharmacology, 177(1), 59-67 (2001).

(46) Hitoshi Ashida, Itsuko Fukuda, Takatoshi Yamashita, and Kazuki Kanazawa.  Flavones and flavonols at dietary levels inhibit a transformation of aryl hydrocarbon receptor induced by dioxin.  FEBS Letters, 476(3), 213-217 (2000).