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西川 伸一 Nishikawa Shinichi

所属・職名理化学研究所 発生・再生科学総合研究センター・副センター長
E-mail
TEL/FAX078-306-1893 / 078-306-1895
研究室ホームページhttp://www.cdb.riken.go.jp/scb/

研究テーマとその内容

幹細胞システムの分子基盤の解明
メラノサイトを使ってニッチの分子基盤解明を目指すとともに、ES細胞からの中胚葉系細胞の分化誘導法を確立する。

代表的論文

  1. Takashima, Y., Era, T., Nakao, K., Kondo, S., Kasuga, M., Smith, A. G., Nishikawa, S. 2007. Neuropepithelial cells supply an initial transient wave of MSC differentiation. Cell 129, 1-12.
  2. Samokhvalov, I. M., Samokhvalova, N. I., and Nishikawa, S. I. 2007. Cell tracing shows the contribution of the yolk sac to adult haematopoiesis. Nature 446, 1056-1061.
  3. Kobayashi, K., Era, T., Takebe, A., Jakt, L. M., and Nishikawa, S. 2006. Malignant Transformation of Mouse Embryonic Fibroblasts and Is Strongly Associated with Malignant Neuroblastoma. Cancer Res 66, 8331-8336.
  4. Moriyama, M., M. Osawa, S.S. Mak, T. Ohtsuka, N. Yamamoto, H. Han, V. Delmas, R. Kageyama, F. Beermann, L. Larue, and S. Nishikawa. 2006. Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells. J Cell Biol 173:333-339.
  5. Uemura, A., S. Kusuhara, S.J. Wiegand, R.T. Yu, and S. Nishikawa. 2006. Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes. J Clin Invest 116:369-377.
  6. Yasunaga, M., S. Tada, S. Torikai-Nishikawa, Y. Nakano, M. Okada, L.M. Jakt, S. Nishikawa, T. Chiba, T. Era, and S. Nishikawa. 2005. Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells. Nat Biotechnol 23:1542-1550.
  7. Osawa, M., G. Egawa, S.S. Mak, M. Moriyama, R. Freter, S. Yonetani, F. Beermann, and S. Nishikawa. 2005. Molecular characterization of melanocyte stem cells in their niche. Development 132:5589-5599.
  8. Nishimura, E.K., S.A. Jordan, H. Oshima, H. Yoshida, M. Osawa, M. Moriyama, I.J. Jackson, Y. Barrandon, Y. Miyachi, and S. Nishikawa. 2002. Dominant role of the niche in melanocyte stem-cell fate determination. Nature 416:854-860.
  9. Yoshida, H., A. Naito, J. Inoue, M. Satoh, S.M. Santee-Cooper, C.F. Ware, A. Togawa, S. Nishikawa, and S.I. Nishikawa. 2002. Different cytokines induce surface lymphotoxin-alphabeta on IL-7 receptor-alpha cells that differentially engender lymph nodes and Peyer's patches. Immunity 17:823-833.
  10. Yamashita, J., H. Itoh, M. Hirashima, M. Ogawa, S. Nishikawa, T. Yurugi, M. Naito, and K. Nakao. 2000. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature 408:92-96.
  11. Yokota, Y., A. Mansouri, S. Mori, S. Sugawara, S. Adachi, S. Nishikawa, and P. Gruss. 1999. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature 397:702-706.
  12. Nishikawa, S.I., S. Nishikawa, M. Hirashima, N. Matsuyoshi, and H. Kodama. 1998. Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin+ cells at a diverging point of endothelial and hemopoietic lineages. Development 125:1747-1757.
  13. Nishikawa, S.I., S. Nishikawa, H. Kawamoto, H. Yoshida, M. Kizumoto, H. Kataoka, and Y. Katsura. 1998. In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos. Immunity 8:761-769.