The cytochrome P450 superfamily plays critical role in the oxidation of xenobiotics, including drugs and environmental pollutants, and therefore represents a primary focus of toxicological and drug metabolism research.
The importance of P450s for toxicological and drug metabolism researches has prompted the development of methods to assay their enzymatic activities. We are trying to develop a methodology for immobilizing membrane-bound P450 on lipid membrane substrate for nano-biosensor. Further developments of the detection methods should open new avenues for the safety evaluation of environments, human body, and foods.

We develop novel technologies on monitoring and remediation of dioxins, endocrine disruptors, and certain pesticide residues with both advantages of animal(receptor and antibody) and plants(dioxin-accumulators).