Cytotoxicity of allyl isothiocyanate and its metabolites in hepatocellular carcinoma HepG2 cells
Takashi Hashimoto, Shino Nakamura, Takeshi Suzuki, Yuka Hasegawa, Kazuki Kanazawa
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 830, 111899, 2025.
DOI: 10.1016/j.mrfmmm.2025.111899.

Anti-malarial activity of allyl isothiocyanate and N-acetyl-S-(N-allylthiocarbamoyl)-L-cysteine
Takashi Hashimoto, Shoji Yoshioka, Shiroh Iwanaga, Kazuki Kanazawa
Molecular Nutrition & Food Research, 67(17), e2300185, 2023.
DOI: 10.1002/mnfr.202300185.

Dietary isosaponarin is intestinally metabolized to isovitexin, most of which are excreted in feces without being absorbed
Takashi Hashimoto, Jiansheng Long, Kazuki Kanazawa
Asian Journal of Food Research and Nutrition, 2(3), 104-116, 2023.

Oral administration of Lactiplantibacillus plantarum 22A-3 exerts anti-allergic activity against intestinal food allergy mouse models sensitized and challenged with ovalbumin
Mari Enokida, Ken-ichro Minato, Susumu Yoshino, Nobuaki Ohto, Hiroshige Kuwahara, Masashi Mizuno
Food Bioscience, 47, 101785, 2022

腸管を介した食物繊維の新規生理活性機構の解明
水野雅史
Nippon Shokuhin Kagaku Kogakukai, 69(5), 203-2111, 2022

Sphingoid base in pineapple glucosylceramide suppresses experimental allergy by binding leukocyte mono-immunoglobulin-like receptor 3
Ayumi Takemura, Nobuaki Ohto, Hiroshige Kuwahara, Masashi Mizuno
Journal of the Science of Food and Agriculture, 102(7), 2074-2079, 2022

Anti-allergic property of 4,8-sphingadienine stereoisomers in vivo and in vitro model
Haruka Shimizu, Masaki Kuse, Ken-ichiro Minato, Masashi Mizuno
Biochemical and Biophysical Reserach Communicaitons, 577, 32-37, 2021

Lactiplantibacillus plantarum 22A-3-induced TGF-β1 secretion from intestinal epithelial cells stimulated CD103+ DC and Foxp3+ Treg differentiation and amelioration of colitis in mice
Jarukan Lamubol, Nobuaki Ohto, Hiroshige Kuwahara, Masashi Mizuno
Food & Function, 12, 8044-8055, 2021

Lactiplantibacillus plantarum 22A-3 isolated from pickle suppresses ovalbumin-induced food allergy in BALB/c mice and 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice.
Masashi Mizuno, Nobuaki Ohto, Hiroshige Kuwahara
Journal of Bioscience and Bioengineering, 132(3), 271-278, 2021

Polysaccharides from Shiitake culinary-medicinal mushroom Lentinus eodes (Agarcomycetes) suppress pMLKL-medicated necroptotic cell death and colitis in mice
Chidube Anthony Alagbaoso, Masashi Mizuno
International Journal of Medicinal Mushrooms, 23(7), 13-26, 2021

Protective effect of boysenberry juice on ferric nitrilotriacetate-induced renal injury in mice
Takashi Hashimoto, Maki Kiyota, Kazuki Kanazawa
European Journal of Medicinal Plants, 32(4), 76-81, 2021.
DOI: 10.9734/ejmp/2021/v32i430386

6-Methylsulfinylhexyl isothiocyanate inhibits cell cycle progression in quiescent JB6 cells stimulated with epidermal growth factor
Takashi Hashimoto, Maki Kobayashi, Kazuki Kanazawa
Annual Research & Review in Biology, 36(6), 19-28, 2021.
DOI: 10.9734/arrb/2021/v36i630386

Artepillin C inhibits cell proliferation by cell cycle arrest at G0/G1 phase accompanied by up-regulation of p27Kip1 in human hepatoma HepG2 cells
Takashi Hashimoto, Weitao Shang, Kazuki Kanazawa
Journal of Complementary and Alternative Medical Research,, 14(1), 30-43, 2021.
DOI: 10.9734/jocamr/2021/v14i130236

Synergistic anti-allergy activity using a combination of Enterococcus faeccalis IC-1 and luteolin
Lulu Han, Iwao Sakane and Masashi Mizuno
Food Bioscience, 41, 100924, 2021

Screening of a Lentinula edodes mutant that retains lentinan contents long after being harvested using TILLING
Yuichi Sakamoto, Shino Sato, Keiko Nakade, Miyuki Ito, Takahiro Yamauchi, Katsumasa Eda, Fumikazu Goto, Masashi Mizuno and Naotake Konno
ACS Agricultural Science & Technology, 1(3), 143-149, 2021

Lactobacillus plantarum 22A-3 exerts anti-allergic activity through TGF-β secretion in passive cutaneous anaphylaxis of mice
Minagi Fujii, Ko Fukuura, Nobuaki Ohto, Hiroshige Kuwahara and Masashi Mizuno
International Journal of Food Science and Nutrition, 72(4), 478-484, 2021.

Polysaccharides from Pyropia yezoensis f. narawaensis ameliorate type I hypersensitivity through the secretion of interleukin 10
Yuki Yonekura, Hikari Ueno, Ken-ichoro Minato, Masashi Mizuno
Food Science and Technology Research, 26(6), 847-854, 2020

Free amino acid, phenolic, flavonoid, β-carroten, lycopene, dehydrotomatine, and α-tomatine contents of peel powders prepared from commercial cherry tomatoes
Mendel Friedman, Hiroyuki Sakakibara, Masashi Mizuno, Dong-Ho Kim, Nobuyuki Kozukue
Current Topics in Phytochemistry, 16, 1-16, 2020

Oral administration of pineapple glucosylceramide improves defective epidermal barrier function by restoring diminished level of TGF-β in the skin
Sakiko Oka, Nobuaki Ohto, Hiroshige Kuwahara, Masashi Mizuno
European Food Research and Technology, 246, 867-874, 2020

Oral administration of fucoidan can exert anti-allergic activity after allergen sensitization by enhancement of galectin-9 secretion in blood
Masashi Mizuno, Kana Sakaguchi, Iwao Sakane
Biomolecules, 10(2), 258, 2020

The analysis of the content of biologically active phenolic compounds, flavonoids, and glycoalkaloids in harvested red, yellow, and green tomatoes, tomato leaves, and tomato stems
Mendel Friedman, Nobuyuki Kozukue, Masashi Mizuno, Hiroyuki Sakakibara, Suk-Hyun Choi, Mihoyo Fujitake, Kirkwood M. Land
Current Topics in Phytochemistry , 15, 43-53, 2019

Influence of temperature on anti-allergic activity of fucoidan extracted from Saccharina japonica
Atsuko Morita, Yuka Tanino, Takao Ojima, Masashi Mizuno
Food Science and Technology Research, 25(4), 607-611, 2019

Pleurotus citrinopileatus polysaccharide stimulates anti-inflammatory properties during monocyte-to-macrophage differentiation
Ken-ichiro Minato, Lisa C. Laan, Irma van Die, Masashi Mizuno
International Journal of Biological Macromolecules, 122, 705-712, 2019

Allyl isothiocyanate increases carbohydrate oxidation through enhancing insulin secretion by TRPV1
Noriyuki Mori, Manami Kurata, Hanae Yamazaki, Shigenobu Matsumura,Takashi Hashimoto, Kazuki Kanazawa, Tomonori Nadamoto, Kazuo Inoue, Tohru Fushiki.
IBioscience, Biotechnology, and Biochemistry, 82(4), 698-708, 2018

Lentinan exerts its anti-inflammatory activity by suppressing TNFR1transfer to the surface of intestinal epithelial cells through Dectin-1 in an in vitro and mice model
Sakaguchi, K., Shirai, Y., Itoh, T. and Mizuno, M.
Immunome Research, 14(3), 1000165, 2018

褐藻類由来高分子多糖フコイダンによる新規抗アレルギー機構
水野雅史、湊健一郎
食品と開発, 53(12), 7-9, 2018

Enhancement of anti-inflammatory and anti-allergic activities with
combination of luteolin and quercetin in in vitro co-culture system
Masashi Mizuno, Sae Yamashita, Takashi Hashimoto
Food Science and Technology Research, 23(6), 7811-818, 2017 J-STAGE

Hot water extract of Grifola gargal possesses anti-inflammatory activity
Masashi Mizuno, Iwao Sakane, Ken-ichiro Minato, Junya Watanabe, Takashi Hashimoto
Food Science and Technology Research, 23(5), 725-732, 2017 J-STAGE

An in vitro investigation of immunomodulatory properties of Lactobacillus plantarum and L. delbrueckii cells and their extracellular polysaccharides
Mana Kishimoto, Ryohei Nomoto, Masashi Mizuno, Ro Osawa
Bioscience of Microbiota, Food and Health, 36(3), 101-110, 2017 J-STAGE

スマート乳酸菌の新機能
大戸信明、水野雅史
Food Style, 21(3), 59-62, 2017

A proinflammatory effect of the β-glucan from Pleurotus cornucopiae mushroom on macrophage action
Ken-ichiro Minato, Akihiro Ohara, Masashi Mizuno
Mediators of Inflammation, 2017, Article ID 8402405, 2017 Hindawi

Glycoalkaloid, phenolic, and flavonoid content and antioxidative activities of conventional nonorganic and organic potato peel powders from commercial gold, red, and Russet potatoes
Mendel Friedman, Nobuyuki Kozukue, Hyun-Jeong Kim, Suk-Hyun Choi, Masashi Mizuno
Journal of Food Composition and Analysis, 62, 69-75, 2017 ScienceDirect

A metabolite of dietary glucosylceramide from pineapples improves the skin barrier function in hairless mice
Takashi Kuwata, Takashi Hashimoto, Nobuaki Ohto, Hiroshige Kuwahara, Jae Won Lee, Takeshi Bamba, Masashi Mizuno
Journal of Functional Foods, 30, 228-236, 2017 ScienceDirect

A novel in vitro co-culture model comprised of Caco-2/RBL-2H3 cells to evaluate anti-allergic effects of food factors through the intestine
Sae Yamashita, Yuki Yokoyama, Hashimoto Takashi, Masashi Mizuno
Journal of Immunological Methods, 435, 1-6, 2016 PubMed

F-fucoidan from Saccharina japonica is a novel inducer of galectin-9 and exhibits anti -allergic activity
Yuka Tanino, Hashimoto Takashi, Takao Ojima, Masashi Mizuno
Journal of Clinical Biochemistry and Nutrition, 59(1), 25-30, 2016

生酛乳酸菌のバイオジェニック効果に着目した米乳酸発酵飲料の開発
高橋俊成、増田康之、吉田和利、水野雅史
生物工学会誌、94(2), 63-69, 2016 日本生物工学会HP

(−)-Epigallocatechin-3-gallate induces secretion of anorexigenic gut hormones
Won-Young Song, Yoshiko Aihara, Takashi Hashimoto, Kazuki Kanazawa, Masashi Mizuno
Journal of Clinical Biochemistry and Nutrition, 57(2), 164-169, 2015 PubMed

Lentinan degradation in the Lentinula edodes fruiting body during postharvest preservation is reduced by downregulation of the exo-β-1,3-glucanase EXG2
Naotake Konno, Keiko Nakiade, Yosuke Nishitani, Masashi Mizuno, Yuichi Sakamoto
Journal of Agricultural and Food Chemistry, 62(32), 8153-8157, 2014 PubMed

Protein, free amino acid, phenolic, β-carotene, and lycopene content, and anti-oxidative and cancer cell inhibi-tory effects of 12 greenhouse-grown commercial cherry toma-to varieties
Suk Hyun Choi, Dong-Seok Kim, Nobuyuki Kozukue, Hyun-Jeong Kim, Yosuke Nishitani, Masashi Mizuno, Carol E. Levin, Mendel Friedman
Journal of food composition and analysis, 34(2), 115-127, 2014　　PubMed

担子菌由来食物繊維と炎症性腸疾患.
水野雅史、西谷洋輔
Functional Food, 7(1), 24-29, 2013

A lipid peroxidation product 9-oxononanoic acid induces phospholipase A2 activity and thromboxane A2 production in human blood.
Rendong Ren, Takashi Hashimoto, Masashi Mizuno, Hirosato Takigawa, Masaru Yoshida, Takeshi Azuma, Kazuki Kanazawa
Journal of Clinical Biochemistry and Nutrition, 52(3), 228-233, 2013　　PubMed

Intestinal anti-inflammatory activity of lentinan: Influence on IL-8 and TNFR1 expression in intestinal epithelial cells
Yosuke Nishitani, Ling Zhang, Masaru Yoshida, Takeshi Azuma, Kazuki Kanazawa, Takashi Hashimoto and Masashi Mizuno
PLoS One, 8(4), e62441, 2013　　PubMed

Intestinal anti-inflammatory activity of luteolin: Role of the aglycone in NF-κB inactivation in macrophages co-cultured with intestinal epithelial cells
Yosuke Nishitani, Koji Yamamoto, Masaru Yoshida, Takeshi Azuma, Kazuki Kanazawa, Takashi Hashimoto, and Masashi Mizuno
Biofactors, 39(5), 522-533, 2013　　PubMed

Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects
Rendong Ren, Yosuke Azuma, Takao Ojima, Takashi Hashimoto, Masashi Mizuno, Yosuke Nishitani, Masaru Yoshida, Takeshi Azuma and Kazuki Kanazawa
British Journal of Nutrition, 110(5), 880-890, 2013　　PubMed

A pilot, randomized, placebo-controlled, double-blind phase 0/biomarker study on effect of artepillin C-rich extract of Brazilian propolis in frequent colorectal adenoma polyp patients
Hideki Ishikawa, Miho Goto, Nariaki Matsuura, Yoshitaka Murakami, Chiho Goto, Toshiyuki Sakai and Kazuki Kanazawa
Journal of the American College of Nutrition, 31(5), 327-337, 2012　　PubMed

Pharmacokinetics of fucoxanthinol in human plasma after the oral administration of kombu extract
Takashi Hashimoto, Yoshiaki Ozaki, Masashi Mizuno, Masaru Yoshida, Yosuke Nishitani, Takeshi Azuma, Akitoshi Komoto, Takashi Maoka, Yuka Taninio and Kazuki Kanazawa
British Journal of Nutrition, 107(11), 1566-1569, 2012　　PubMed

Short photoirradiation induces flavonoid synthesis and increases its production in postharvest vegetables
Kazuki Kanazawa, Takashi Hashimoto, Satoko Yoshida, Sungwon Park and Shinya Fukuda
Journal of Agricultural and Food Chemistry, 60(17), 4359-4368. 2012　　PubMed

Oral treatment with extract of Agaricus blazei Murill enhanced Th1 response through intestinal epithelial cells and suppressed OVA-sensitized allergy in mice

Go Bouike, Yosuke Nishitani, Hideyuki Shiomi, Masaru Yoshida, Takeshi Azuma, Takashi Hashimoto, Kazuki Kanazawa and Masashi Mizuno
Evidence-Based Complementary and Alternative Medicine, 2011(10), Article ID 532180, 2011　　PubMed

Bioavailability of non-nutrients for preventing lifestyle-related diseases
Kazuki Kanazawa
Trends in Food Science & Technology, 22(12), 655-659, 2011　　ScienceDirect

Artemisia princeps extract promoted glucose uptake in cultured L6 muscle cells via glucose transporter 4 translocation.
Norio Yamamoto, Manabu Ueda, Kyuichi Kawabata, Takuya Sato, Kengo Kawasaki, Takashi Hashimoto and Hitoshi Ashida
Bioscience, Biotechnology, and Biochemistry, 74(10), 2036-2042, 2010　　PubMed

Membrane fusion process and assembly of cell wall during cytokinesis in the brown alga, Silvetia babingtonii (Fucales, Phaeophyceae)
Chikako Nagasato, Akira Inoue, Masashi Mizuno, Kazuki Kanazawa, Takao Ojima, Kazuo Okuda and Taizo Motomura
Planta, 232(2), 287-298, 2010　　PubMed

Fucoxanthin induces apoptosis in osteoclast-like cells differentiated from RAW264.7 cells
Swadesh K. Das, Rendong Ren, Takashi Hashimoto and Kazuki Kanazawa
Journal of Agricultural and Food Chemistry, 58(10), 6090-6095. 2010 (26 May)　　PubMed

Different suppressive effects of fucoidan and lentinan on IL-8 mRNA expression in vitro gut inflammation
Masashi Mizuno, Yosuke Nishitani, Takashi Hashimoto and Kazuki Kanazawa
Bioscience, Biotechnology, and Biochemistry, 73(10), 2324-2325, 2009　　PubMed

The distribution and accumulation of fucoxanthin and its metabolites after oral administration in mice
Takashi Hashimoto, Yoshiaki Ozaki, Mayuko Taminato, Swadesh K. Das, Masashi Mizuno, Kazuto Yoshimura, Takashi Maoka and Kazuki Kanazawa
British Journal of Nutrition, 102(2), 242-248, 2009　　PubMed

Quantification and localization of fucoidan in Laminaria japonica using a novel antibody
Masashi Mizuno, Yosuke Nishitani, Takeshi Tanoue, Yoshie Matoba, Takao Ojima, Takashi Hashimoto and Kazuki Kanazawa
Bioscience, Biotechnology, and Biochemistry, 73(2), 335-338, 2009 (23 February)　　PubMed

Inhibitory effects of caffeine and its metabolites on intracellular lipid accumulation in murine 3T3-L1 adipocytes
Hideo Nakabayashi, Takashi Hashimoto, Hitoshi Ashida, Shin Nushiumi and Kazuki Kanazawa
Biofactors, 34(4), 293-302, 2008

Commercial-scale preparation of biofunctional fucoxanthin from waste parts of brown sea algae Laminalia japonica
Kazuki Kanazawa, Yoshiaki Ozaki, Takashi Hashimoto, Swadesh K. Das, Saori Matsushita, Masashi Hirano, Tadashi Okada, Akihiko Komoto, Nobuki Mori and Masahiro Nakatsuka
Food Science and Technology Research, 14(6), 573-582, 2008 (18 February, 2009)　　J-STAGE

トウガラシ幼植物の茎葉を食用とする新しい野菜に含まれる一酸化窒素ラジカル（NO）産生抑制物質
田中義行、大津圭吾、中村年一、細川宗孝、山口加乃子、金沢和樹、矢澤進
園芸学研究、7（4）、491-497、2008 （25 October, 2008）　　J-STAGE

A formation mechanism for 8-hydroxy-2-deoxyguanosine mediated by peroxidized 2-deoxythymidine
Miho Goto, Keisuke Ueda, Takashi Hashimoto, Shinji Fujiwara, Kayo Matsuyama, Takashi Kometani and Kazuki Kanazawa
Free Radical Biology and Medicine, 45(9), 1318-1325, 2008 (1 November)　　PubMed

In vitro model to estimate gut inflammation using co-cultured Caco-2 and RAW264.7 cells
Takeshi Tanoue, Yosuke Nishitani, Kazuki Kanazawa, Takashi Hashimoto and Masashi Mizuno
Biochemical and Biophysical Research Communications, 374(3), 565-569, 2008 (26 September)　　PubMed

Fucoxanthin induced apoptosis in human hepatocarcinoma HepG2 cells
Yosuke Azuma, Takashi Hashimoto, Hiroki Nomura, Swadesh K. Das, Yoshiaki Ozaki and Kazuki Kanazawa
Journal of Clinical Biochemistry and Nutrition, 43(Suppl. 1), 273-276. 2008 (July)

Accumulation of fucoxanthin and its metabolites in mice after ad libitum administration of kombu extract-containing diet for one month
Yoshiaki Ozaki, Shin-ichi Katsumata, Mariko Uehara, Takashi Hashimoto, Swadesh K. Das, Kazuharu Suzuki and Kazuki Kanazawa
Journal of Clinical Biochemistry and Nutrition, 43(Suppl. 1), 269-272. 2008 (July)

Preventive effects of wasabi leaf extract on carcinogenic initiation
Mayumi Okamoto, Takashi Hashimoto, Miho Goto, Masashi Nagai, Isao Okunishi and Kazuki Kanazawa
Journal of Clinical Biochemistry and Nutrition, 43(Suppl. 1), 251-254. 2008 (July)

Screening for phytoestrogens that exhibit binding affinity to the androgen receptor
Takashi Hashimoto, Midori Nobuchii and Kazuki Kanazawa
Journal of Clinical Biochemistry and Nutrition, 43(Suppl. 1), 132-135. 2008 (July)

Consumption of horseradish leaf extract regulates drug-metabolizing enzymes in mice
Mayumi Okamoto, Takashi Hashimoto, Miho Goto, Shinji Fujiwara, Masashi Nagai, Isao Okunishi and Kazuki Kanazawa
Journal of Clinical Biochemistry and Nutrition, 43(Suppl. 1), 124-127. 2008 (July)

Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D
Swadesh K. Das, Takashi Hashimoto and Kazuki Kanazawa
Biochimica et Biophysica Acta - General Subjects, 1780(4), 743-749. 2008 (April)　　PubMed

Metabolic conversion of dietary quercetin from its conjugate to active aglycone following the induction of hepatocarcinogenesis in fisher 344 rats
Naomi Oi, Takashi Hashimoto and Kazuki Kanazawa
Journal of Agricultural and Food Chemistry, 56(2), 577-583. 2008 (23 January)　　PubMed

Absorption of dietary licorice isoflavan glabridin to blood circulation in rats
Chinatsu Ito, Naomi Oi, Takashi Hashimoto, Hideo Nakabayashi, Fumiki Aoki, Yuji Tominaga, Shinichi Yokota, Kazunori Hosoe and Kazuki Kanazawa
Journal of Nutritional Science and Vitaminology, 53(4), 358-365. 2007 (August)　　PubMed

Yellow tea is more potent than other types of tea on suppressing liver toxicity induced by carbon tetrachloride in rats
Takashi Hashimoto, Miho Goto, Hiroyuki Sakakibara, Naomi Oi, Mayumi Okamoto and Kazuki Kanazawa
Phytotherapy Research, 21(7), 668-670. 2007 (July)　　PubMed

Halocynthiaxanthin and peridinin sensitize colon cancer cell lines to tumor necrosis factor-related apoptosis-inducing ligand
Tatsushi Yoshida, Takashi Maoka, Swadesh K. Das, Kazuki Kanazawa, Mano Horinaka, Miki Wakada, Yoshiko Satomi, Hoyoku Nishino and Toshiyuki Sakai
Molecular Cancer Research, 5(6), 615-625. 2007 (June)　　PubMed

Development of a method to remove cyanogen glycosides from flaxseed meal
Takatoshi Yamashita, Takashi Sano, Takashi Hashimoto and Kazuki Kanazawa
International Journal of Food Science & Technology, 42(1), 70-75. 2007

Bioavailable flavonoids to suppress the formation of 8-OHdG in HepG2 cells
Kazuki Kanazawa, Ai Uehara, Hiroyuki Yanagiyani and Takashi Hashimoto
Archives of Biochemistry and Biophysics, 455(2), 197-203. 2006　　PubMed

Comparative study of antioxidative activity among the Six Great Chinese teas; green, white, yellow, oolong, black, and pu-erh teas
Takashi Hashimoto, Naomi Oi, Hiroyuki Sakakibara, Miho Goto and Kazuki Kanazawa
ITE letters on Batteries, New Technologies & Medicine, 7(5), 484-487. 2006

A frequent drinking of green tea lowers the levels of endogenous oxidative stress in small intestines, erythrocytes and kidneys in rats
Hiroyuki Sakakibara, Hitoshi Ashida, Itsuko Fukuda, Takashi Furuyashiki, Takashi Sano, Yuji Nonaka, Takashi Hashimoto and Kazuki Kanazawa
Journal of Clinical Biochemistry and Nutrition, 39(1), 32-39. 2006　　J-STAGE

Japanese kelp (kombu) extract suppressed the formation of aberrant crypt foci in azoxymethane challenged mouse colon
Swadesh K. Das, TakashiHashimoto, Masaki Baba, Hoyoku Nishino, Akitoshi Komoto and Kazuki Kanazawa
Journal of Clinical Biochemistry and Nutrition, 38(2), 119-125. 2006　　J-STAGE

Effects of combined administration of quercetin, rutin, and extract of white radish sprout rich in kaempferol glycosides on the metabolism in rats
Takashi Hashimoto, Yuko Ueda, Naomi Oi, Hiroyuki Sakakibara, Chengyuan Piao, Hitoshi Ashida, Miho Goto and Kazuki Kanazawa
Bioscience, Biotechnology, and Biochemistry, 70(1), 279-281. 2006　　PubMed

Artepillin C in Brazilian propolis induces G₀/G₁ arrest via stimulation of Cip1/p21 expression in human colon cancer cells
Kazuo Shimizu, Swadesh K. Das, Takashi Hashimoto, Yoshihiro Sowa, Tatsushi Yoshida, Toshiyuki Sakai, Yukinaga Matsuura and Kazuki Kanazawa
Molecular Carcinogenesis, 44(4), 293-299. 2005　　PubMed

Fucoxanthin induces cell cycle arrest at G₀/G₁ phase in human colon carcinoma cells through up-regulation of p21^WAF1/Cip1
Swadesh K. Das, Takashi Hashimoto, Kazuo Shimizu, Tatsushi Yoshida, Toshiyuki Sakai, Yoshihiro Sowa, Akitoshi Komoto and Kazuki Kanazawa
Biochimica et Biophysica Acta - General Subjects, 1726(3), 328-335. 2005　　PubMed

Dietary artepillin C suppresses the formation of aberrant crypt foci induced by azoxymethane in mouse colon
Kazuo Shimizu, Swadesh K. Das, Masaki Baba, Yukinaga Matsuura and Kazuki Kanazawa
Cancer Letters, 240(1), 135-142. 2005　　PubMed

Effects of Japanese kelp (kombu) on life span of benzo[a]pyrene-fed mice
Hiroyuki Sakakibara, Satoshi Nakagawa, H. Wakameda, Y. Nakagiri, Kimiko Kamata, Swadesh K. Das, T. Tsuji and Kazuki Kanazawa
Journal of Nutritional Science and Vitaminology, 51(5), 369-373. 2005　　PubMed

Black tea theaflavins suppress dioxin-induced transformation of the aryl hydrocarbon receptor
Itsuko Fukuda, Iwao Sakane, Yoshiyuki Yabusita, Shin-ichi Sawamura, Kazuki Kanazaw and Hitoshi Ashida
Bioscience, Biotechnology, and Biochemistry, 69(5), 883-890. 2005　　PubMed

The catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARγ2 and C/EBPα in 3T3-L1 cells
Takashi Furuyashiki Hironobu Nagayasu, Yukiko Aoki, Hiroaki Bessho, Takashi Hashimoto, Kazuki Kanazawa and Hitoshi Ashida
Bioscience, Biotechnology, and Biochemistry, 68(11), 2353-2359. 2004 (November)　　PubMed

Equol, a metabolite of daidzein, inhibits bone loss in ovariectomized mice
Maiko Fujioka, Mariko Uehara, Jian Wu, Herman Adlercreutz, kazuharu Suzuki, Kazuki Kanazawa, Ken Takeda, Kazuhiro Yamada and Yoshiko Ishimi
Journal of Nutrition, 134(10), 2623-2627. 2004 (October)　　PubMed

Anti-obesity actions of green tea: possible involovements in modulation of the glucose uptake system and suppression of the adipogenesis-related transcription factors
Hitoshi Ashida, Takashi Nakabayashi, Hironobu Nagayasu, Hiroaki Bessho, Hiroyuki Sakakibara, Takashi Hashimoto, and Kazuki Kanazawa
BioFactors, 22(1-4), 135-140. 2004　　PubMed

Lentinan from shiitake mushroom (Lentinus edodes) suppressed expression of cytochrome P450 1A subfamily in the mouse liver
Takashi Okamoto, Rie Kodoi, Yuji Nonaka, Itsuko Fukuda, Takashi Hashimoto, Kazuki Kanazawa, Masashi Mizuno and Hitoshi Ashida
BioFactors, 21(1-4), 407-409. 2004　　PubMed

Anthocyan does not suppress transformation of aryl hydrocarbon receptor induced by dioxin
Rie Mukai, Itsuko Fukuda, Shin Nishiumi, Keizo Hosokawa, Kazuki Kanazawa and Hitoshi Ashida
BioFactors, 21(1-4), 371-373. 2004　　PubMed

Black tea extract suppresses transformation of aryl hydrocarbon receptor induced by dioxin
Itsuko Fukuda, Iwao Sakane, Yoshiyuki Yabushita, Shin-ichi Sawamura, Kazuki Kanazawa and Hitoshi Ashida
BioFactors, 21(1-4), 367-369. 2004　　PubMed

Caffeine inhibits cell proliferation by G₀/G₁ phase arrest in JB6 cells
Takashi Hashimoto, Zhiwei He, Wei-Ya Ma, Patricia C. Schmid, Ann M. Bode, Chung S. Yang and
Zigang Dong
Cancer Research, 64(94), 3344-3349. 2004 (May 1)　　PubMed

Pigments in green tea leaves (Camellia sinensis) suppress transformation of the aryl hydrocarbon receptor induced by dioxin
Itsuko Fukuda, Iwao Sakane, Yoshiyuki Yabushita, Rie Kodoi, Shin Nishiumi, Takami Kakuda, Shin-ichi Sawamura, Kazuki Kanazawa, and Hitoshi Ashida
Journal of Agricultural and Food Chemistry, 52(9), 2499-2506. 2004 (May 5)　　PubMed

Antioxidative bioavailability of artepillin C in Brazilian propolis
Kazuo Shimizu, Hitoshi Ashida, Yukinaga Matsuura and Kazuki Kanazawa
Archives of Biochemistry and Biophysics, 424(2), 181-188. 2004 (April 15)　　PubMed

3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole induces apoptosis and necrosis with activation of different caspases in rat splenocytes
Takashi Hashimoto, Takashi Sano, Wakana Ito, Kazuki Kanazawa, Gen-ichi Danno and Hitoshi Ashida
Bioscience, Biotechnology, and Biochemistry, 68(4), 964-967. 2004 (April)　　PubMed

Green tea extract inhibits etoposide-induced apoptosis in rat thymocytes
Takashi Hashimoto, Wakako Fukushima, Wakana Ito, Michihiro Takagi, Kazuki Kanazawa and Hitoshi Ashida
ITE Letters on Batteries, New Technologies & Medicine, 5(1), 73-78. 2004

Induction of apoptosis by caffeine is mediated by the p53, Bax, and caspase 3 pathways
Zhiwei He, Wei-Ya Ma, Takashi Hashimoto, Ann M. Bode, Chung S. Yang and Zigang Dong
Cancer Research, 63(15), 4396-4401. 2003 (August 1)　　PubMed

Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice
Hiroshige Chiba, Mariko Uehara, Jian Wu, Xinxiang Wang, Ritsuko Masuyama, Kazuharu Suzuki, Kazuki Kanazawa and Yoshiko Ishimi
Journal of Nutrition, 133(6), 1892-1897. 2003 (June)　　PubMed

Simultaneous determination of all polyphenols in vegetables, fruits, and teas
Hiroyuki Sakakibara, Yoshinori Honda, Satoshi Nakagawa, Hitoshi Ashida, and Kazuki Kanazawa
Journal of Agricultural and Food Chemistry, 51(3), 571-581. 2003 (January 29)　　PubMed

Apoptosis in the thymus after intraperitoneal injection of rats with Trp-P-1
Takashi Hashimoto, Takashi Furuyashiki, Takashi Sano, Kaori Kihara, Itsuko Fukuda, Wakana Ito, Pyoyun Park, Kazuki Kanazawa, Gen-ichi Danno and Hitoshi Ashida
Environmental and molecular mutagenesis, 40(3), 175-183. 2003　　PubMed

Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice
Takashi Hashimoto, Yuji Nonaka, Ken-ichiro Minato, Sachiko Kawakami, Masashi Mizuno, Itsuko Fukuda, Kazuki Kanazawa and Hitoshi Ashida
Bioscience, Biotechnology, and Biochemistry, 66(7), 1610-1614. 2003 (July)　　PubMed

3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) is incorporated into rat splenocytes, thymocytes, and hepatocytes through monoamine transporters and induces apoptosis
Takashi Hashimoto, Takashi Furuyashiki, Takashi Sano, Wakana Ito, Gen-ichi Danno, Kazuki Kanazawa and Hitoshi Ashida
Bioscience, Biotechnology, and Biochemistry, 66(6), 1205-1212. 2003 (June)　　PubMed

A novel method using 8-hydroperoxy-2'-deoxyguanosine formation for evaluating antioxidative potency
Hiroyuki Sakakibara, Hitoshi Ashida and Kazuki Kanazawa
Free Radical Research, 36(3), 307-316. 2002 (March)　　PubMed

Subsequent products after antioxidant actions of β-carotene and α-tocopherol have no Salmonella mutagenicity
Mingzhou Sun, Ryo Yamauchi, Hitoshi Ashida and Kazuki Kanazawa
Bioscience, Biotechnology, and Biochemistry, 66(2), 363-372. 2002 (Feburary)　　PubMed

Evoking cytochrome P450 1A activity interferes with apoptosis induced by 3-amino-1,4-dimethyl-5H-pyrido [4,3-b]indole (Trp-P-1) in rat hepatocytes under the ex vivo system.
Bunsyo Shiotani, Yuji Nonaka, Kazuki Kanazawa, Gen-ichi Danno and Hitoshi Ashida
Bioscience, Biotechnology, and Biochemistry, 66(2), 356-362. 2002 (Feburary)　　PubMed

3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) is incorporated into rat splenocytes, thymocytes, and hepatocytes through monoamine transporters and induces apoptosis
Takashi Hashimoto, Takashi Furuyashiki, Takashi Sano, Wakana Ito, Gen-ichi Danno, Kazuki Kanazawa and Hitoshi Ashida
Bioscience, Biotechnology, and Biochemistry, 66(6), 1205-1212. 2003 (June)　　PubMed