最近の学術論文 (2003年以降)


・原著論文


  1. Miwa, T., Ohtani, K., Inoue, K., and Sakamoto, H. (2022)
    The germ cell-specific TAP-like protein NXF-2 forms a novel granular structure and is required for tra-2 3'UTR-dependent mRNA export in Caenorhabditis elegans.
    Genes to Cells 27, 621-628.
  2. Miwa, T., Inoue, K., and Sakamoto, H. (2019)
    MRG-1 is required for both chromatin-based transcriptional silencing and genomic integrity of primordial germ cells in C. elegans.
    Genes to Cells 24, 377-389.
    [PUBMED 30929290]
  3. Kobayashi, M., Tani-Matsuhana, S., Ohkawa, Y., Sakamoto, H., and Inoue, K. (2017)
    DND protein functions as a translation repressor during zebrafish embryogenesis.
    Biochem. Biophys. Res. Commun. 484, 235-240
    [PUBMED 28115159]
  4. Yamamoto, K., Furukawa, M.T., Fukumura, K., Kawamura, A., Yamada, T., Suzuki, H., Hirose, T., Sakamoto, H., and Inoue, K (2016)
    Control of the heat stress-induced alternative splicing of a subset of genes by hnRNP K.
    Genes to Cells 21, 1006-1014
    [PUBMED 27491955]
  5. Fukumura, K., Wakabayashi, S., Kataoka, N., Sakamoto, H., Suzuki, Y., Nakai, K., Mayeda, A. and Inoue, K. (2016)
    The Exon Junction Complex controls the efficient and faithful splicing of a subset of transcripts involved in mitotic cell-cycle progression.
    International Journal of Molecular Sciences 17(8), e1153. [PUBMED 27490541]
  6. Miwa, T., Takasaki, T., Inoue, K., and Sakamoto, H. (2015)
    Restricted distribution of mrg-1 mRNA in C. elegans primordial germ cells through germ granule-independent regulation.
    Genes to Cells 20, 932-942
    . [PUBMED 26537333]
  7. Furukawa, M.T., Sakamoto, H., Inoue, K.(2015)
    Interaction and colocalization of HERMES/RBPMS with NonO, PSF, and G3BP1 in neuronal cytoplasmic RNP granules in mouse retinal line cells.
    Genes to Cells 20, 257-266.
    [PUBMED 25651939]
  8. Tani, S., Kuraku, S., Sakamoto, H., Inoue, K., and Kusakabe, R.(2013)
    Developmental expression and evolution of muscle-specific microRNAs conserved in vertebrates.
    Evolution & Development
    15, 293-304
  9. Shiimori, M., Inoue, K., Sakamoto, H.(2013)
    A specific set of exon junction complex subunits is required for the nuclear retention of unspliced RNAs in Caenorhabditis elegans.
    Mol. Cell. Biol. 33, 444-456
    [PUBMED 23149939]
  10. Mishima, Y., Fukao, A., Kishimoto, T., Sakamoto, H., Fujiwara, T., Inoue, K.(2012)
    Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish.
    Proc. Natl. Acad. Sci. USA 109, 1104-1109 [PUBMED 22232654]
  11. Fujiwara, T., Fukao, A., Sasano, Y., Matsuzaki, H., Kikkawa, U., Imataka, A., Inoue, K., Endo, S., Sonenberg, N. Thoma, C., & Sakamoto, H.(2012)
    Functional and direct interaction between the RNA binding protein HuD and active Akt1.
    Nucleic Acids Res.
    40, 1944-1953 [PUBMED 22075994]
  12. Kim HS, Murakami R, Quintin S, Mori M, Ohkura K, Tamai KK, Labouesse M, Sakamoto H, Nishiwaki K.(2011)
    VAB-10 spectraplakin acts in cell and nuclear migration in Caenorhabditis elegans.
    Development 138, 4013-23 [PUBMED 21831923]
  13. Fujiwara, Y., Kasashima, K., Saito, K., Fukuda, M., Fukao, A., Sasano, Y., Inoue, K., Fujiwara, T., & Sakamoto, H. (2011)
    Microtubule association of a neuronal RNA-binding protein HuD through its binding to the light chain of MAP1B.
    Biochimie
    93, 817-22 [PUBMED 21288476]
  14. Hokii, Y., Sasano, Y., Sato, M., Sakamoto, H., Sakata, K., Shingai, R., Taneda, A., Oka, S., Himeno, H., Muto, A., Fujiwara, T., & Ushida, C. (2010)
    A small nucleolar RNA functions in rRNA processing in C. elegans.
    Nucleic Acids Res.
    38, 5909-18 [PUBMED 20460460]
  15. Tani, S., Kusakabe, R., Naruse, K., Sakamoto, H., & Inoue, K.(2010)
    Genomic organization and embryonic expression of miR-430 in medaka (Oryzias latipes): insights into the post-transcriptional gene regulation in early development.
    Gene 449, 41-49
    [PUBMED 19770025]
  16. Fukao, A., Sasano, Y., Imataka, H., Inoue, K., Sakamoto, H., Sonenberg, N., Thoma, C & Fujiwara, T.(2009)
    The ELAV protein HuD stimulates cap-dependent translation in a poly(A)- and eIF4A-dependent manner.
    Mol. Cell 36,1007-1017
    [PUBMED 20064466]
    (see also Preview by Chen and Shyu in Mol. Cell Dec. 24)
  17. Takeda, Y., Mishima, Y., Fujiwara, T., Sakamoto, H., & Inoue, K.(2009)
    DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish.
    PLoS ONE 4, e7513
    [PUBMED 19838299]
  18. Fukumura, K., Taniguchi, I., Sakamoto, H., Ohno, M., & Inoue, K. (2009)
    U1-independent pre-mRNA splicing contributes to the regulation of alternative splicing.
    Nucleic Acids Res. 37, 1907-1914 [PUBMED 19190090]
  19. Higuchi, S., Hayashi, T., Tarui, H., Nishimura, O., Nishimura, K., Shibata, N., Sakamoto, H. & Agata, K. (2008)
    Expression and functional analysis of musashi-like genes in planarian CNS regeneration.
    Mech. Dev. 125, 631-45 [PUBMED 18440787]
  20. Sasano, Y., Hokii, Y., Inoue, K., Sakamoto, H., Ushida, C. & Fujiwara, T. (2008)
    Distribution of U3 small nucleolar RNA and fibrillarin during early embryogenesis in Caenorhabditis elegans.
    Biochimie. 90, 898-907 [PUBMED 18312858]
  21. Fukumura, K., Kato, A., Jin, Y., Ideue, T., Hirose, T., Kataoka, N., Fujiwara, T., Sakamoto, H., & Inoue, K.(2007)
    Tissue-specific splicing regulator Fox-1 induces exon skipping by interfering E complex formation on the downstream intron of human F1γ gene.
    Nucleic Acids Res. 35, 5303-5311
    [PUBMED 17686786]
  22. Higuchi, S., Hayashi, T., Hori, I., Shibata, N., Sakamoto, H. & Agata, K. (2007)
    Characterization and categorization of fluorescence activated cell sorted planarian stem cells by ultrastructural analysis.
    Dev. Growth Differ. 49, 571-581[PUBMED 17587325]
  23. Takano, T., Pulvers, J.N., Inoue, T., Tarui, H., Sakamoto, H., Agata, K. & Umesono, Y. (2007)
    Regeneration-dependent conditional gene knockdown (Readyknock) in planarian: Demonstration of requirement for Djsnap-25 expression in the brain for negative phototactic behavior.
    Dev. Growth Deffer. 49, 383-394 [PUBMED 17547648]
  24. Takasaki, T., Liu, Z., Habara, Y., Nishiwaki, K., Nakayama, J., Inoue, K., Sakamoto, H., & Strome, S. (2007)
    MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans.
    Development  134, 757-767 [PUBMED 17215300]
    (see also In This Issue in Development Feb. 15)
  25. Kosaka, K., Kawakami, K., Sakamoto, H., & Inoue, K.(2007)
    Spatiotemporal localization of germ plasm RNAs during zebrafish oogenesis.
    Mech. Dev.124,279-289
    [PUBMED 17293094]
  26. Mishima, Y., Giraldez, A.J., Takeda, Y., Fujiwara, T., Sakamoto, H., Schier, A.F., & Inoue, K. (2006)
    Differential regulation of germline specific mRNAs in soma and primordial germ cells by zebrafish miR-430.
    Current Biology 16, 2135-2142 [PUBMED 17084698]
  27. Saito, K., Fujiwara, T., Katahira, J., Inoue, K., & Sakamoto, H. (2004) TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD. Biochem. Biophys. Res. Commun. 321, 291-297. [PUBMED 15358174]
  28. Saijou, E., Fujiwara, T., Suzaki, T., Inoue, K., & Sakamoto, H. (2004) RBD-1, a nucleolar RNA-binding protein, is essential for Caenorhabditis elegans early development through 18S ribosomal RNA processing. Nucleic Acids Res. 32, 1028-1036. [PUBMED 14872060]
  29. Kawano, T., Kataoka, N., Dreyfuss, G. and Sakamoto, H. (2004) Ce-Y14 and MAG-1, components of the exon-exon junction complex, are required for embryogenesis and germline sexual switching in Caenorhabditis elegans. Mech. Dev. 121, 27-35. [PUBMED 14706697]
  30. Fujita, M., Hawkinson, D., King, K.V., Hall, D.H., Sakamoto, H. and Buechner, M. (2003) The role of the ELAV homologue EXC-7 in the development of the Caenorhabditis elegans excretory canals. Dev. Biol. 256, 290-301. [PUBMED 12679103]


・総説等

 1.椎森仁美・坂本博 (2009):線虫生殖細胞の性分化におけるRNAの制御 
  蛋白質核酸酵素 Vol.54「mRNAプログラム:多様性と非対称性の獲得戦略」(2009年12月号増刊 共立出版), 2153-2158.

 2.高崎輝恒・笹野有未・坂本 博 (2008):線虫C. elegansからのRNA抽出
  「RNA実験ノート 上巻」第1章 p. 24-p. 28(2008年3月発行 羊土社)

 3.藤原俊伸・坂本 博 (2006):RNA結合蛋白質が主役となる神経系での転写後遺伝子発現調節
  蛋白質核酸酵素(2006年12月号増刊)「RNAと生命」VII.RNAと高次生命現象、51、2609-2616

 4.三嶋 雄一郎・坂本 博・ 井上 邦夫(2004):mRNA局在化の分子機構
   実験医学増刊 Vol.22-No.17(2004年11月発行 羊土社) 「躍進するRNA研究」p.2545-p.2460

 5.Thomas Tuschl著、坂本博訳(2004):哺乳類におけるRNAi: RNAi: A Guide to Gene Silencing(中村 義一監修)
  メディカル・サイエンス・インターナショナル(2004年10月発行)第13章p.257-p.286

 6.笠嶋克巳・坂本 博 (2003):RNA結合蛋白質の構造と機能
  蛋白質核酸酵素 Vol.48(2003年3月号増刊)「RNAの細胞生物学」 III. スプライシングと輸送,390-397


・新聞記事

  読売 07年2月19日掲載記事(PDFファイル)


戻る