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久世雅樹(Masaki Kuse)


2011年9月 - 神戸大学 大学院農学研究科 准教授
2007年4月 - 名古屋大学 物質科学国際研究センター 助教
2004年4月 - 名古屋大学 物質科学国際研究センター 助手
2001年4月 - 名古屋大学 化学測定機器センター 助手
2000年4月 - 名古屋大学 大学院生命農学研究科 リサーチアソシエイト
1997年4月 - 日本学術振興会 特別研究員(DC1)

2000年3月 名古屋大学 大学院農学研究科 応用分子生命科学専攻 
博士課程(後期課程)修了 博士(農学)
(指導教授:磯部 稔先生)
1997年3月 名古屋大学 大学院生命農学研究科 応用分子生命科学専攻
1995年3月 名古屋大学 農学部 農芸化学科 卒業
1991年3月 富山県立 富山中部高等学校 卒業

農芸化学奨励賞 受賞(2013年3月24日)
第42回 天然有機化合物討論会(沖縄) 奨励賞 受賞(2000年11月7日)
「沖縄産トビイカ(Symplectoteuthis oualaniensis L.)の発光タンパク質symplectinとその生物発光の分子機構の研究」



  1. Nguyen, H. T. H., Bouteau, F., Mazars, C., Kuse, M., Kawano, T. Enhanced elevations of hypo-osmotic shock-induced cytosolic and nucleic calcium concentrations in tobacco cells by pretreatment with dimethyl sulfoxide. Biosci. Biotechnol. Biochem. 2019, 83, 318-321.
  2. H. T. H. Nguyen, F. Bouteau, C. Mazars, M. Kuse & T. Kawano. The involvement of calmodulin and protein kinases in the upstream of cytosolic and nucleic calcium signaling induced by hypoosmotic shock in tobacco cells. Plant Signaling & Behavior 2018, e1494467, 1-7.
  3. Takahashi, K., Matsui, M., Kuse, M., Takikawa,H. First synthesis of (S)-(+)-hymenoic acid, a DNA polymerase λ inhibitor isolated from Hymenochaetaceae sp. Biosci. Biotechnol. Biochem. 2017, 82, 42-45.
  4. Kuse, M., Moriguchi, M., Hachida, M., Takikawa, H. Total Synthesis of (±)-Ramariolides C and D. Chem. Lett. 2017, 47, 1409-1411.
  5. Kunishima, M., Yamauchi, Y., Mizutani, M., Kuse, M., Takikawa, H., Sugimoto, Y. Leaf Aldehyde in Plants Identification of (Z)-3:(E)-2-Hexenal Isomerases. J. Biol. Chem. 2016, 291, 14023-14033
  6. Yamamoto, S., Kuse, M., Takikawa, H. First synthesis of (±)-hostasolide A. Tetrahedron Lett. 2015, 56, 5808-5810.
  7. Kumagai, H., Fujiwara, M., Kuse, M., Takikawa, H. A concise synthesis of optically active solanacol, the germination stimulant for seeds of root parasitic weeds. Biosci. Biotechnol. Biochem. 2015, 79, 1240-1245.
  8. Masaki Kuse. Chromophores in photoproteins of a glowing squid and mollusk. Biosci. Biotechnol. Biochem. 2014, 78, 731-736.
  9. Yuta Kohno, Masatsugu Koso, Masaki Kuse, Hirosato Takikawa. Formal synthesis of soybean phytoalexin glyceollin I. Tetrahedron Letters. 2014, 55, 1826-1828.
  10. Masashi Tanaka, Yukihiro Sugimoto, Masaki Kuse, and Hirosato Takikawa. Synthesis of 7-oxo-5-deoxystrigol, a 7-oxygenated strigolactone analog. Biosci. Biotechnol. Biochem. 2013, 77, 832-835.
  11. Kimiharu Nakazaki, Kojiro Hayashi, Shintaro Hosoe, Takuya Tashiro, Masaki Kuse, Hirosato Takikawa. First synthesis of decaturin C, an antiinsectant diterpenoid iolatd from Penicillium thiersii. Tetrahedron 2012, 68, 9029-9034.
  12. Vorawan Kongjinda, Yosuke Nakashima, Naoki Tani, Masaki Kuse, Toshio Nishikawa, Chin-Hui Yu, Nobuyuki Harada, and Minoru Isobe. Dynamic Chirality determines Critical Roles for Bioluminescence in Symplectin-Dehydrocoelenterazine System. Chemistry-An Asian Journal 2011, 6, 2080-2091.
  13. Masaki Kuse*, Miho Yanagi, Eiko Tanaka, Naoki Tani, and Toshio Nishikawa. Identification of a Fluorescent Compound in the Cuticle of the Train Millipede Parafontaria laminata armigera. Bioscience, Biotechnology, and Biochemistry 2010, 74, 2307-2309.
  14. Eiko Tanaka, Masaki Kuse*, and Toshio Nishikawa. Dehydrocoelenterazine is the organic substance constituting the Prosthetic group of pholasin. ChemBioChem 2009, 10, 2725-2729.
  15. Tomoko Kagenishi, Ken Yokawa, Masaki Kuse, Minoru Isobe, Francois Bouteau, and Tomonori Kawano. Prevention of Copper-Induced Calcium Influx and Cell Death by Prion-Derived Peptide in Suspension-Cultured Tobacco Cells. Zeitschrift für Naturforschung 2009, 64c, 411-417.
  16. Arthit Makarasen, Masaki Kuse, Toshio Nishikawa, and Minoru Isobe. Substituent Effect of Imino-O-arenesulfonates, a Coupling Partner in Suzuki-Miyaura Reaction for Substitution of the Pyrazine Ring: A Study for the Synthesis of Coelenterazine Analogs. Bulletin ofthe Chemical Society of Japan 2009, 82, 870-878.
  17. Issei Doi, Masaki Kuse, Toshio Nishikawa, and Minoru Isobe. Selective oxidation by the hydroperoxide in the photoprotein, aequorin. Bioorganic & Medicinal Chemistry 2009, 17, 3399-3404.
  18. Magne O. Sydnes, Masaki Kuse, Issei Doi, and Minoru Isobe. 1H NMR Aided Elucidation of Products Derived from Photodegradation of Ethyl 3-azido-4,6-difluorobenzoate in 2,2,2-Trifluoroethanol. Tetrahedron 2009, 65, 3863-3870.
  19. Issei Doi, Masaki Kuse, Yosuke Nakashima, Naoki Tani, and Minoru Isobe. Differentiation of coelenteramide sulfate from phosphate by hydrogen/deuterium exchange coupled with ion trap mass spectrometry. Journal of the Mass Spectrometry Society of Japan 2009, 57, 89-95.
  20. Minoru Isobe, Masaki Kuse, Naoki Tani, Tatsuya Fujii, and Tsukasa Matsuda. Cysteine-390 is the binding site of luminous substance with symplectin, a photoprotein from Okinawan squid, Symplectoteuthis oualaniensis. Proceedings of Japan Academy, Ser. B, Physical and Biological Sciences 2008, 84, 386-392.
  21. Masaki Kuse*, Eiko Tanaka, and Toshio Nishikawa. Pholasin luminescence is enhanced by addition of dehydrocoelenterazine. Bioorganic & Medicinal Chemistry Letters 2008, 18, 5657-5659.
  22. Magne O. Sydnes, Masaki Kuse, and Minoru Isobe. Reductive monoalkylation of nitro aryls in one-pot. Tetrahedron 2008, 64, 6406-6414.
  23. Magne O. Sydnes, Masaki Kuse, Masakuni Kurono, Aya Shimomura, Hiroshi Ohinata, Akira Takai, and Minoru Isobe. Protein Phosphatase Inhibitory Activity of Tautomycin Photoaffinity Probes Evaluated at Femto-molar Level. Bioorganic & Medicinal Chemistry 2008, 16, 1747-1755.
  24. Magne O. Sydnes, Issei Doi, Ayako Ohishi, Masaki Kuse, and Minoru Isobe. Determination of Solvent-Trapped Products Derived from Photolysis of Aryl Azides in 2,2,2-Trifluoroethanol. Chemistry - An Asian Journal 2008, 3, 102-112.
  25. Cun Lin, Yawei Yu, Takashi Kadono, Michiaki Iwata, Kenji Umemura, Takuya Furuichi, Masaki Kuse, Minoru Isobe, Yoko Yamamoto, Hideaki Matsumoto, Kazuharu Yoshizuka, and Tomonori Kawano. Action of aluminum, novel TPC1-type channel inhibitor, against salicylate-induced and cold-shock-induced calcium influx in tobacco BY-2 cells. Biochemical and Biophysical Research Communication 2005, 332, 823-830.
  26. Masaki Kuse, Issei Doi, Nobuhiro Kondo, Yukari Kageyama, and Minoru Isobe. Synthesis of Azide-Fluoro-Dehydrocoelenterazine analog as a Photoaffinity-Labeling Probe and Photolysis of Azide-Fluoro-Coelenterazine. Tetrahedron 2005, 61, 5754-5762.
  27. Nobuhiro Kondo, Masaki Kuse, Thumnoon Mutarapat, Nopporn Thasana, and Minoru Isobe. Novel synthetic route of coelenterazines-2-: Synthesis of various dehydrocoelenterazine analogs. Heterocycles 2005, 64, 843-856.
  28. Tomonori Kawano, Takashi Kadono, Katsumi Fumoto, Frédéric Lapeyrie, Masaki Kuse, Minoru Isobe, Takuya Furuichi, and Shoshi Muto. Aluminum as a specific inhibitor of plant TPC1 Ca2+ channels. Biochemical and Biophysical Research Communication 2004, 324, 40-45.
  29. Suthasinee Pitchayawasin, Minoru Isobe, Masaki Kuse, Thomas Franz, Norio Agata, and Michio Ohta. Molecular diversity of cereulide detected by means of nano-HPLC-ESI-Q-TOF-MS. International Journal of Mass Spectrometry 2004, 235, 123-129.
  30. Masaki Kuse, Nobuhiro Kondo, Yuki Ohyabu, and Minoru Isobe. Novel Synthetic Route of Aryl-Aminopyrazine. Tetrahedron 2004, 60, 835-840.
  31. Suthasinee Pitchayawasin, Masaki Kuse, Kazushi Koga, Minoru Isobe, Norio Agata, and Michio Ohta. Complexation of cyclic dodecadepsipeptide, Cereulide with ammonium salts. Bioorganic & Medicinal Chemistry Letters 2003, 13, 3507-3512.
  32. Fujii Tatsuya, Jon-Yob Ahn, Masaki Kuse, Hitoshi Mori, Tsukasa Matsuda, and Minoru Isobe. A novel 60 kDa-photoprotein from oceanic squid (Symplectoteuthis oualaniensis) with sequence similarity to mammalian carbon-nitrogen hydrolase domains. Biochemical and Biophysical Research Communication 2002, 293, 874-879.
  33. Minoru Isobe, Tatsuya Fujii, Masaki Kuse, Keiichi Miyamoto, and Kazushi Koga. 19F-Dehydrocoelenterazine as Probe to Investigate the Active Site of Symplectin. Tetrahedron 2002, 58, 2117-2126.
  34. Masaki Kuse, Akira Kanakubo, Sathorn Suwan, Kazushi Koga, Minoru Isobe, and Osamu Shimomura. 7,8-Dihydropterin-6-carboxylic acid as Light Emitter of Luminous Millipede, Luminodesmus sequoiae. Bioorganic & Medicinal Chemistry Letters 2001, 11, 1037-1040.
  35. Masaki Kuse, and Minoru Isobe. Synthesis of 13C-Dehydrocoelenterazine and NMR Studies on the Bioluminescence of a Symplectoteuthis Model. Tetrahedron 2000, 56, 2629-2639.
  36. Masaki Kuse, Thomas Franz, Kazushi Koga, Sathron Suwan, Minoru Isobe, Norio Agata, and Michio Ohta. High Incorporation of L-Amino Acid to Cereulide, an Emetic Toxin from Bacillus cereus. Bioorganic & Medicinal Chemistry Letters 2000, 10, 735-739.
  37. Minoru Isobe, Tatsuya Fujii, Sathron Suwan, Masaki Kuse, Katsunori Tsuboi, Asaka Miyazaki, Meow C. Feng, and Jianmin Li. Chemistry of photoproteins as interface between bioactive molecules and protein function. Pure and Applied Chemistry 1998, 70, 2085-2092.
  38. Minoru Isobe, Masaki Kuse, Yoshio Yasuda, and Hiroyuki Takahashi. Synthesis of 13C-Dehydrocoelenterazine and Model Studies on Symplectoteuthis Squid Bioluminescence. Bioorganic & Medicinal Chemistry Letters 1998, 8, 2919-2924.


久世雅樹、磯部 稔.農芸化学の事典、担当:農芸化学分野における質量分析、鈴木昭憲、荒井綜一編集(朝倉書店)、904ページ、担当:268-275ページ、2003年.


  1. 久世雅樹.; ヒカリカモメガイ由来の発光タンパク質(フォラシン)―小さな発見に至るまでの長い道のり. 化学と生物、2014, 52, 166-171.
  2. 金久保暁、久世雅樹、磯部 稔.; 「もの」が語るバイオサイエンス-2:発光物質が語るバイオサイエンス. 化学と生物、2003, 41, 605-613.
  3. 磯部 稔、久世雅樹.; 生物発光と化学エネルギ−.;化学と教育、2000, 48, 22-25.
  4. 磯部 稔、久世雅樹.; 化学発光と生物発光およびその利用.; ファルマシア、1998, 34, 20-24.
  5. 磯部 稔、藤井辰也、宇佐見研、久世雅樹.; 生物発光の化学・最新の進歩.; 生化学、1996, 68, 1683-1691.


  1. Yosuke Nakashima, Vorawan Kongjinda, Naoki Tani, Masaki Kuse, and Minoru Isobe. Chemistry for biology of symplectin bioluminescence with fluoro-dehydrocoelenterazine. Chemiluminescence and Bioluminescence 2009, 51-54.
  2. Minoru Isobe, Tsukasa Matsuda, Masaki Kuse, Hitoshi Mori, Tatsuya Fujii, Nobuhiro Kondo, and Yukari Kageyama. Studies on the bioluminescent mechanism of the symplectin photoprotein. Chemiluminescence and Bioluminescence 2005, 7-10.
  3. Minoru Isobe, Tsukasa Matsuda, Masaki Kuse, Hitoshi Mori, Tatsuya Fujii, Nobuhiro Kondo, and Yukari Kageyama. Studies on the bioluminescent mechanism of the symplectin photoprotein. Luminescence 2004, 19, 157-158.
  4. Minoru Isobe, Masaki Kuse, Tatsuya Fujii, and Ken Usami. Synthesis and Proof of 1,2-Dioxetanone: Low-temperature Photooxygenation of Coelenterate Luciferin Analog. LANDMARKS IN PHOTOBIOLOGY 1998, 149-156.


  1. Masaki Kuse. Identification of a fluorescent compound of a luminescent millipede. The 9th Joint Seminar JSPS-NRCT Core University Program. Bangkok, December 8, 2010.
  2. Masaki Kuse. Chemical Biology of the marine bioluminescence with coelenterazines. The Seminar of the JSPS-NRCT Core University Program. Hat Yai (Thailand), September 8, 2009.
  3. Masaki Kuse. Marine bioluminescence with coelenterate compounds. The 8th Joint Seminar JSPS-NRCT Core University Program. Bangkok, February 3, 2009.
  4. Masaki Kuse. Squid Bioluminescence. NSF-Thai REU program 2006. Bangkok, August 9, 2006.


  1. 久世雅樹:ヒカリカモメガイの光る仕組みを有機化学で解明する。日本農芸化学会中四国支部 第29回 若手シンポジウム(第11回 農芸化学の未来開拓セミナー)(岡山大学農学部)2019.5.24. 講演要旨集p. 11.
  2. 久世雅樹:発光タンパクで利用されるヘテロ芳香環化合物の合成と活性評価。近畿化学協会 ヘテロ原子部会 平成29年度第1回懇話会(尼崎:岩谷産業(株)中央研究所)2017.5.15.
  3. 久世雅樹:海洋生物由来の発光タンパク質に関する生物有機化学的研究。日本農芸化学会関西支部会 第482回 講演会(神戸:神戸大学)2013.12.7. 講演要旨集p. 19.
  4. 久世雅樹:トビイカとヒカリカモメガイの生物発光に関する研究。第8回化学生態学研究会、湯川プリンスホテル渚亭、函館、2013.6.28. 講演要旨集p. 1.
  5. 久世雅樹:海洋生物由来の発光タンパク質に関する生物有機化学的研究(農芸化学奨励賞 受賞者講演)。日本農芸化学会 2013年度大会(仙台:東北大学)2013.3.24. 講演要旨集p. 25.
  6. 久世雅樹:細胞内シグナル伝達機構解明の為の生物発光基質の創出。日本植物学会 第74回大会、中部大学、愛知、2010. 9.
  7. 久世雅樹:二枚貝発光タンパク質に関する生物有機化学的研究。生物発光化学発光研究会 第26回学術講演会、電気通信大学、東京、2009. 6.
  8. 磯部 稔、久世雅樹:アジアの最先端有機化学―アジア地域の天然有機化合物研究―。名古屋大学科学研究フォーラム、名古屋、2005. 12.

VII. 競争的資金の獲得状況

科学研究費補助金 研究代表者:

  1. 日本学術振興会 科学研究費助成事業(学術研究助成基金助成金) 基盤研究(C)
  2. 日本学術振興会 科学研究費助成事業(学術研究助成基金助成金) 基盤研究(B)
  3. 日本学術振興会 科学研究費助成事業(学術研究助成基金助成金) 基盤研究(C)
  4. 日本学術振興会 科学研究費助成事業(学術研究助成基金助成金) 基盤研究(C)
  5. 文部科学省 科学研究費補助金 若手研究B
  6. 文部科学省 科学研究費補助金 若手研究B
  7. 文部科学省 科学研究費補助金 若手研究B
  8. 文部科学省 科学研究費補助金 若手研究B

VIII. その他(刊行物)

  1. 久世雅樹:「10年経って見えてきた課題」内藤財団時報 2011, 87
  2. 久世雅樹:「タンパク質が光ること」内藤財団時報 2002, 70