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Our genomic DNA is constantly damaged by its intrinsic vulnerability, endogenously-produced agents such as reactive oxygen species, and various environmental factors including ultraviolet light, radiations, and chemical compounds. Such DNA damage induces not only chromosomal aberrations and mutations, causing cancer and hereditary diseases, but also apoptosis, possibly leading to ageing and neurological degeneration. To avoid these deleterious effects, multiple DNA repair pathways have evolved to maintain the genome integrity. Our laboratory focuses on understanding of: 1) molecular mechanisms underlying DNA repair and its regulation, and 2) signal transduction pathways regulating cellular responses to DNA damage.