神戸大学環境物質科学研究室


Research activities:


General direction

We are surrounded by diverse types of life in the environment. Human body has also evolved to sustain its life by organizing cooperative functions of organs. Our research is concerned with the biological functions that enable the cooperation in and between human body and the environment, especially focusing on the human metabolism and plant uptake of xenobiotics. To assess the safety of the chemicals and to clean the environment, we apply molecular biological techniques, micro-fabrication and sensing techniques, and transgenic plants.

Hiromasa Imaishi (Professor)
The human is exposed to the environmental substances such as agrochemical, medical, and industrial chemical every day. Some chemical substances have a risk of impairing human health. From a viewpoint of safety evaluation of environmental substances, we have been studying the metabolism of chemicals in human body. It is well known that drug-metabolizing enzymes play an important role in the detoxification and activation of foreign substances. Cytochrome P450 monooxygenases are the most important enzymes for the metabolism of chemicals in an organism. Our research is focusing on the production of toxic chemicals in human body by cytochrome P450. Furthermore, we are also trying to establish biosynthesis systems for the production of useful chemicals from conventional chemicals by using cytochrome P450 monooxygenases.



Kenichi Morigaki (Associate professor)
Biological membranes act as an interface between cells and the surrounding environment. They are related with important functions such as signal transduction and immunological responses. Therefore, it is important to understand and manipulate their functions for various biomedical applications, including drug development and diagnostics. We are developing an artificial model system for biological membranes on solid substrates to mimick and evaluate the functions of the biological membrane. To this end, micropatterned lipid membranes composed of polymerized and fluid lipid bilayers are generated by the lithographic photopolymerization of a diacetylene-containing phospholipid. We aim at generating robust model systems that can reproduce the functions of membrane proteins, including cytochrome P450.




Hideyuki Inui (Associate professor)
Environmental contaminants including dioxins and dioxin-like compounds, endocrine disruptors, and pesticide residues are widely distributed into the environment by our social activities and have adverse effects to ecosystem and the human by their bioaccumulation via the food chain. Development of new technologies on remediation and monitoring of them is important for maintenance of safety in food supply. Animals have metabolism (enzymes) and perception (receptors) abilities toward exogenous compounds. In contrast, plants have absorption and accumulation toward low concentrations of compounds via their root systems. We have developed integrated remediation and monitoring (bioassay) systems with these features of animals and plants. The transgenic plants with drug-metabolizing enzymes and receptors succeeded to remediate and monitor environmental contaminants, respectively. Researches on absorption and accumulation mechanisms of environmental contaminants in plants and utilization of antibodies for monitoring are in progress.





Publication list




Staff:


Hiromasa Imaishi (Professor)
Professional Experience
2008-present Professor, Kobe University (Kobe, Japan)
1998-2008 Associate professor, Kobe University (Kobe, Japan)
1994-1995 Postdoctoral fellow, Rockefeller University (New York, USA)
1992-1998 Assistant professor, Kobe University (Kobe, Japan)
1990-1992 Assistant professor, Yamaguchi University (Ube, Japan)

Higher education
1987-1990 Division of Chemistry, Graduate School of Science, Kyoto University (Kyoto Japan), Ph.D.
1985-1987 Department of Chemistry, Kyoto Institute of Technology (Kyoto, Japan) Master in Engineering
1981-1985 Department of Chemistry, Kyoto Institute of Technology (Kyoto, Japan) Bachelor in Engineering

Research Area
1) Biochemistry, Molecular Biology and Chemical biology
2) Pharmacokinetics of Environmental Chemicals
3) Agrochemical Science


Kenichi Morigaki (Associate professor)
Professional Experience
2009-present Associate professor, Kobe University (Kobe, Japan)
2007-2009 Senior Research Scientist, AIST (Ikeda, Japan)
2002-2007 Research Scientist, AIST (Ikeda, Japan)
2000-2002 Postdoctoral fellow, Department of Material Science, Swiss Federal Institute of Technology-Zurich (Zurich, Switzerland)
1998-2000 Postdoctoral fellow, Max-Planck-Institute of Polymer Research (Mainz, Germany)

Higher education
1993-1998 Department of Chemistry, Swiss Federal Institute of Technology-Zurich (Zurich, Switzerland) Ph.D.
1991-1993 Department of Chemical Energy, University of Tokyo (Tokyo, Japan) Master in Engineering
1986-1991 Department of Industrial Chemistry, University of Tokyo (Tokyo, Japan) Bachelor in Engineering

Research Area
1) Biological membranes
2) Analytical chemistry
3) Biochips and biosensors


Hideyuki Inui (Associate professor)
Professional Experience
2012-Present Associate professor, Research Center for Environmental Genomics, Kobe University (Kobe, Japan)
2012-Present Associate professor, Graduate School of Agricultural Science, Kobe University (Kobe, Japan)
2009-2012 Senior Assistant Professor, Research Center for Environmental Genomics, Kobe University (Kobe, Japan)
2009-2012 Senior Assistant Professor, Graduate School of Agricultural Science, Kobe University (Kobe, Japan)
2001-2009 Assistant Professor, Research Center for Environmental Genomics, Kobe University (Kobe, Japan)
2001-2002 Visiting Assistant Professor, Rockefeller University, (New York, USA)
2000-2000 Research Assistant, Rockefeller University, (New York, USA)
1999-2009 Assistant Professor, Faculty of Agriculture, Kobe University (Kobe, Japan)

Higher education
1996-1999 Graduate School of Science and Technology, Kobe University (Kobe, Japan) Ph.D
1994-1996 Graduate School of Science and Technology, Kobe University (Kobe, Japan) Master in Agriculture
1990-1994 Faculty of Agriculture, Kobe University (Kobe, Japan) Bachelor in Agriculture

Research Area
1) Phytoremediation
2) Bioassay
3) Plant genetic engineering


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