Natural Products ChemistryGraduate School of Agricultural Science, Kobe University |
Diary in Lab
@Facebook page of our Lab. (in Japanese)
2014.10.30.@Literature seminar (Yamamoto)
Diethelm, S.; Schindler, C.S.; Carreira, E.M. Access to the Aeruginosin Serine Protease Inhibitors through the Nucleophilic Opening of an Oxabicyclo[2.2.1]heptane: Total Synthesis of Microcin SF608. Chem. Eur. J. 2014, 20, 6071-6080.
2014.10.23.@Literature seminar (Matsuoka)
Calder, E.D.D.; McGonagle, F.I.; Harkiss, A.H.; McGonagle, G.A.; Sutherland, A. Preparation of Amino-Substituted Indenes and 1,4-Dihydronaphthalenes Using a One-Pot Multireaction Approach: Total Synthesis of Oxybenzo[c]phenanthridine Alkaloids. J. Org. Chem. 2014, 79, 7633-7648.
2014.7.16.@Literature seminar (Hamazaki)
Jafarpour, F.; Zarei, S.; Olia, M.B.A.; Jalalimanesh, M.; Rahiminejadan, S. Palladium-Catalyzed Decarboxylative Cross-Coupling Reactions: A Route for Regioselective Functionalization of Coumarins. J. Org. Chem. 2013, 78, 2957-2964.
2014.7.16.@Literature seminar (Nakanishi)
Granger, B.A.; Jewett, I.T.; Butler, J.D.; Martin, S.F. Concise total synthesis of (})-actinophyllic acid. Tetrahedron 2014, 70, 4094-4104.
2014.7.16.@Literature seminar (Kaji)
Qiu, D.; Wang, S.; Tang, S.; Meng, H.; Jin, L.; Mo, F.; Zhang, Y.; Wang, J. Synthesis of Trimethylstannyl Arylboronate Compounds by Sandmeyer-Type Transformations and Their Applications in Chemoselective Cross-Coupling Reactions. J. Org. Chem. 2014, 79, 1979-1988.
2014.7.9.@Literature seminar (Maeda)
Takahashi, K.; Komine, K.; Yokoi, Y.; Ishihara, J.; Hatakeyama, S. Stereocontrolled Total Synthesis of (-)-Englerin A. J. Org. Chem. 2012, 77, 7364-7370.
2014.7.9.@Literature seminar (Kumagai)
Chen, V.X.; Boyer, F.D.; Rameau, C.; Pillot, J.P.; Vors, J.P.; Beau, J.M. New Synthesis of A-Ring Aromatic Strigolactone Analogues and Their Evaluation as Plant Hormones in Pea (Pisum sativum). Chem. Eur. J. 2013, 19, 4849-4857.
2014.7.2.@Literature seminar (Oka)
Jolibois, A.E.R.; Lewis, W.; Moody, C.J. Total Synthesis of (})-Distomadines A and B. Org. Lett. 2014, 16, 1064-1067.
2014.6.24.@Literature seminar (Ishihara)
Huang, J.; Foyle, D.; Lin, X.; Yang, J. Total Synthesis and Biological Evaluation of an Antifungal Tricyclic o-Hydroxy-p-Quinone Methide Diterpenoid. J. Org. Chem. 2013, 78, 9166-9173.
2014.6.18.@Literature seminar (Yamazoe)
Prasad, KR.; Revu, O. Total Synthesis of (+)-Seimatopolide A. J. Org. Chem. 2014, 79, 1461-1466.
2014.6.4.@Literature seminar (Hachida)
Oblak, EZ.; VanHeyst, MD.; Li, J.; Wiemer, AJ.; Wright, DL. Cyclopropene Cycloadditions with Annulated Furans: Total Synthesis of (+)- and (-)-Frondosin B and (+)-Frondosin A. J. Am. Chem. Soc. 2014, 136, 4309-4315.
2014.5.28.@Literature seminar (Atarashi)
Yue, G.; Yang, L.; Yuan, C.; Du, B.; Liu, B. Total syntheses of lindenane-type sesquiterpenoids: (})-chloranthalactones A, B, F, (})-9-hydroxy heterogorgiolide, and (})-shizukanolide E. Tetrahedron 2012, 68, 9624-9637.
2014.5.20.@Literature seminar (Yamamoto)
Shi, Y.; Wilmot, JT.; Nordstrom, LU.; Tan, DS.; Gin, DY. Total Synthesis, Relay Synthesis, and Structural Confirmation of the C18-Norditerpenoid Alkaloid Neofinaconitine. J. Am. Chem. Soc. 2013, 135, 14313-14320.
2014.5.14.@Literature seminar (Matsuoka)
Smith, JM.; Moreno, J.; Boal, BW.; Garg, NK. Total Synthesis of the Akuammiline Alkaloid Picrinine. J. Am. Chem. Soc. 2014, 136, 4504-4507.
2014.4.22.@Literature seminar (Ueda)
Mikula, H.; Skrinjar, P.; Sohr, B.; Ellmer, D.; Hametner, C.; Frohlich, J. Total synthesis of masked Alternaria mycotoxins-sulfates and glucosides of alternariol (AOH) and alternariol-9-methyl ether (AME). Tetrahedron 2013, 69, 10322-10330.
2014.4.7.@New members joined
2014.1.30.@Literature seminar (Hirade)
Du, B,; Jiang, X.; Sun, P. Palladium-Catalyzed Highly Selective ortho-Halogenation (I, Br, Cl) of Arylnitriles via sp2 C-H Bond Activation Using Cyano as Directing Group. J. Org. Chem. 2013, 78, 2786-2791.
2014.1.23.@Literature seminar (Hachida)
Chen, I.T.; Baitinger, I.; Schreyer, L.; Trauner, D. Total Synthesis of Sandresolide B and Amphilectolide. Org. Lett. 2014, 16, 166-169.
2014.1.16.@Literature seminar (Kobayashi)
Ozawa, T.; Kanematsu, M.; Yokoe, H.; Yoshida, M.; Shishido, K. Total Synthesis of Debromoflustramines B and E Based on the Intramolecular Carbamoylketene-Alkene [2 + 2] Cycloaddition. J. Org. Chem. 2012, 77, 9240-9249.
2014.1.9.@Literature seminar (Kawasaki)
Liu, Q.; Zhang, YA.; Xu, P.; Jia, Y. Total Synthesis of (+)-Lysergic Acid. J. Org. Chem. 2013, 78, 10885-10893.
2013.12.19.@Literature seminar (Ueda J)
Takao, K.; Nanamiya, R.; Fukushima, Y.; Namba, A.; Yoshida, K.; Tadano, K. Total Synthesis of (+)-Clavilactone A and (-)-Clavilactone B by Ring-Opening/Ring-Closing Metathesis. Org. Lett. 2013, 15, 5582-5585.
2013.12.12.@Literature seminar (Atarashi)
Han, J.C.; Liu, L.Z.; Chang, Y.Y.; Yue, G.Z.; Guo, J.; Zhou, L.Y.; Li, C.C.; Yang, Z. Asymmetric Total Synthesis of Caribenol A via an Intramolecular Diels-Alder Reaction. J. Org. Chem. 2013, 78, 5492-5504.
2013.12.7@Matsuoka received the presentation-award from the sponsored companies at the 482nd Kansai branched meeting of JSBBAi@ Kobe Univ.j. Title: Analog of luminescent substance whcih emits longer wavelength.
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2013.12.5.@Literature seminar (Yamamoto)
Urabe, F.; Nagashima, S.; Takahashi, K.; Ishihara, J.; Hatakeyama, S. Total Synthesis of (-)-Cinatrin C1 Based on an In(OTf)3-Catalyzed Conia-Ene Reaction. J. Org. Chem. 2013, 78, 3847-3857.
2013.11.28.@Literature seminar (Moriguchi)
Zhang, W.J.; Wu, J.F.; Zhou, P.F.; Wang, Y.; Hou, A.J. Total syntheses of norartocarpin and artocarpin. Tetrahedron. 2013, 69, 5850-5858.
2013.11.21.@Literature seminar (Matsuoka)
Zhao, H.; Kato, A.; Sato, K.; Jia, Y-M.; Yu, C-Y. Total Synthesis and Glycosidase Inhibition of Broussonetine I and J2. J. Org. Chem.. 2013, 78, 7896-7902.
2013.11.14.@Literature seminar (Sekiya)
Fujioka, H.; Nakahara, K.; Kotoku, N.; Ohba, Y.; Nagatomi, Y.; Wang, TL.; Sawama, Y.; Murai, K.; Hirano, K.; Oki, T.; Wakamatsu, S.; Kita, Y. Asymmetric Total Synthesis of (-)-Stenine and 9a-epi-Stenine. Chem. Eur. J.. 2012, 18, 13861-13870.
2013.11. 8.@Literature seminar (Ueda S)
Nemecek, G; Thomas, R.; Goesmann, H.; Feldmann, C.; Podlech, J. Structure Elucidation and Total Synthesis of Altenuic Acid III and Studies towards the Total Synthesis of Altenuic Acid II. Eur. J. Org. Chem.. 2013, 28, 6420-6432.
2013.11. 1.@Literature seminar (Wada)
Zhang, M.; Liu, N.; Tang, W. Stereoselective Total Synthesis of Hainanolidol and Harringtonolide via Oxidopyrylium-Based [5 + 2] Cycloaddition. J. Am. Chem. Soc.. 2013, 135, 12434-12438.
2013.10.25.@Literature seminar (Morioka)
Rodrigo, E.; Garcia Ruano, J.L.; Cid, M.B. Organocatalytic Michael Addition/Intramolecular Julia-Kocienski Olefination for the Preparation of Nitrocyclohexenes. J. Org. Chem.. ASAP DOI: 10.1021/jo401686u
2013.10.17.@Literature seminar (Hata)
Williams, D.R.; Myers, B.J.; Mi, L.; Binder, R.J. Studies for the Total Synthesis of Amphidinolide P. J. Org. Chem.. 2013, 78, 4762-4778.
2013.10.10.@Literature seminar (Nango)
Jakubec, P.; Hawkins, A.; Felzmann, W.; Dixon, D.J. Total Synthesis of Manzamine A and Related Alkaloids. J. Am. Chem. Soc. 2012, 134, 17482-17485.
2013.7.17.@Literature seminar (Hirade)
Sato, K.; Zhu, M.; Takenaga, N. A facile preparation of modified hydrophilic azulene derivatives. Tetrahedron Lett. 2013, 54, 3204-3206.
2013.7.10.@Literature seminar (2) (Ueda, J.)
Okamoto, R.; Takeda, K.; Tokuyama, H.; Ihara, M.; Toyota, M. Toward the Total Synthesis of (})-Andrastin C. J. Org. Chem. 2013, 78, 93-103.
2013.7.10.@Literature seminar (1) (Kawasaki)
Borrero, N.V.; Aponick, A. Total Synthesis of Acortatarin A Using a Pd(II)-Catalyzed Spiroketalization Strategy. J. Org. Chem. 2012, 77, 8410-8416.
2013.7.3.@Literature seminar (Hachida)
Gregg, C.; Perkins, M.V. Total synthesis and structural elucidation of ent-micropyrone and (+)-ascosalipyrone. Org. Biomol. Chem. 2012, 10, 6547-6553.
2013.6.26.@Literature seminar (Kobayashi)
Perez, L.; Alibes, R.; de March, P.; Busque, F.; Figueredo, M.; Font, J. Stereodivergent Synthesis of (+)- and (-)-Isolineatin. J. Org. Chem. 2013, 78, 4483-4489.
2013.6.19.@Literature seminar (Atarashi)
Beingessner, R.L.; Farand, J.A.; Barriault, L. Progress toward the Total Synthesis of (})-Havellockate. J. Org. Chem. 2010, 75, 6337-6346.
2013.6.12.@Literature seminar (Yamamoto)
An, C.; Jurica, J.A.; Walsh, S.P.; Hoye, A.T.; Smith, A.B. III. Total Synthesis of (+)-Irciniastatin A (a.k.a. Psymberin) and (-)-Irciniastatin B. J. Org. Chem. 2013, 78, 4278-4296.
2013.6.5.@Literature seminar (Moriguchi)
Liau, B.B.; Milgram, B.C.; Shair, M.D. Total Syntheses of HMP-Y1, Hibarimicinone, and HMP-P1. J. Am. Chem. Soc. 2012, 134, 16765-16772.
2013.5.29.@Literature seminar (Matsuoka)
Feldman, K.S.; Antoline, J.F. Synthesis studies on the Melodinus alkaloid meloscine. Tetrahedron 2013, 69, 1434-1445.
2013.5.22.@Literature seminar (Sekiya)
Davies, S.G.; Fletcher, A.M.; Lee, J.A.; Lorkin, T.J.A.; Roberts, P.M.; Thomson, J.E. Asymmetric Synthesis of (-)-Martinellic Acid. Org. Lett. 2013, 15, 2050-2053.
2013.5.15.@Literature seminar (Ueda, S.)
Keita, M.;, Bona, R.D.; Santos, M.D.; Lequin, O.; Ongeri, S.; Milcent, T.; Crousse, B. Access to novel amino trifluoromethyl cyclopropane carboxylic acid derivatives. Tetrahedron. 2013, 69, 3308-3315.
2013.5.8.@Literature seminar (Wada)
Adams, G.L.; Carroll, P.J.; Smith, A.B. III. Access to the Akuammiline Family of Alkaloids: Total Synthesis of (+)-Scholarisine A. J. Am. Chem. Soc. 2013, 135, 519-528.
2013.5.1.@Literature seminar (Morioka)
Taylor, R.R.R.; Batey, R.A. A Hetero Diels-Alder Approach to the Synthesis of Chromans (3,4-Dihydrobenzopyrans) Using Oxonium Ion Chemistry: The Oxa-Povarov Reaction. J. Org. Chem. 2013, 78, 1404-1420.
2013.4.24@Literature seminar (Hata)
Tsuna, K.; Noguchi, N.; Nakada, M. Enantioselective Total Synthesis of (+)-Ophiobolin A. Chem. Eur. J. 2013, 19, 5476-5486.
2013.4.17@Literature seminar (Nango)
White, J.D.; Li, Y.; Kim, J.; Terinek, M. A Novel Synthesis of (-)-Huperzine A via Tandem Intramolecular Aza-Prins Cyclization-Cyclobutane Fragmentation. Org. Lett. 2013, 15, 882-885.
2013.1.29@Literature seminar (Yamamoto)
Fujimoto, T.; Fukuyama, T.; Wakimoto, T.; Asakawa, T.; Hamashima, Y.; Kan, T. Stereocontrolled Total Synthesis of (+)-UCS1025A. Angew. Chem. Int. Ed. 2012, 51, 12850-12853.
2013.1.22@Literature seminar (Nakahara)
Rokade, B.; Prabhu, K.R. Chemoselective Schmidt Reaction Mediated by Triflic Acid: Selective Synthesis of Nitriles from Aldehydes. J. Org. Chem.. 2012, 77, 5364-5370.
2013.1.15@Literature seminar (Kubo)
Wang, X.; Wang, X.; Tan, X.; Lu, J.; Cormier, K.W.; Ma, Z.; Chen, C. A Biomimetic Route for Construction of the [4+2] and [3+2] Core Skeletons of Dimeric Pyrrole-Imidazole Alkaloids and Asymmetric Synthesis of Ageliferins. J. Am. Chem. Soc. 2012, 76, 484-491.
2012.12.18@Literature seminar (Ooishi)
Jin, W.; Li, Z.; Wan, B. A Highly Diastereo- and Enantioselective Copper(I)-catalyzed Henry Reaction Using a Bis(sulfonamide)-Diamine Ligand. J. Org. Chem. 2011, 76, 484-491.
2012.12.11@Literature seminar (Wada)
Peng, F.; Danishefsky,S. Total Synthesis of (})-Maoecrystal V. J. Am. Chem. Soc. 2012, 134, 18860-18867.
2012.11.27@Literature seminar (Morioka)
Liu, Y.; Liu, X.; Wang, M.; He, P.; Lin, L.; Feng, X. Enantioselective Synthesis of 3,4-Dihydropyran Derivatives via Organocatalytic Michael Reaction of α,β-Unsaturated Enones. J. Org. Chem. 2012, 77, 4136-4142.
2012.11.20@Literature Seminar (Hata)
Hanessian, S.; Vakiti, R.R.; Dorich, S.; Banerjee, S.; Deschênes-Simard, B. Total Synthesis of Pactamycin and Pactamycate. J. Org. Chem. 2012, 77, 9458-9472.
2012.11.12@Literature seminar (Nango)
Liu, P.; Seo, J.H.; Weinreb, S.M. Total Synthesis of the Polycyclic Fungal Metabolite (})-Communesin F. Angew. Chem. Int. Ed. 2010, 49, 2000-2003.
2012.10.29@Literature seminar (Tanaka)
Frost, J.R.; Pearson, C.M.; Snaddon, T.N.; Booth, R.A.; Ley, S.V. Convergent Total Synthesis of Callipeltosides A, B, and C. Angew. Chem. Int. Ed. 2012, 51, 9366-9371.
2012.10.23@Literature seminar (Kohno)
Imai, T.; Nakata, H.; Yokoshima, S.; Fukuyama, T. Synthetic Studies toward Ecteinascidin 743 (Trabectedin). Synthesis 2012, 44, 2743-2753.
2012.8.9@ Open Day: Kobe University.
Many high school students visited our scientific events to see what is going on in our labo.
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2012.7.17@Literature seminar (Yamamoto)
Ogura, Y.; Ishigami, K.; Watanabe, H. Total Synthesis of (})-Lysidicin A. Tetrahedron 2012, 68, 1723-1728.
2012.7.10. Literature Seminar (Nakahara)
Stanway, S.J.; Thomas, E.J. 1,5-Stereocontrol in tin(IV) halide mediated reaction between N and S-substituted pent-2-enylstannanes and aldehyde or imines. Tetrahedron 2012, 68, 5998-6009.
2012.7.3.@Literature seminar (Kubo)
Huters, A.; Quasdorf, K.W.; Styduhar, E.D.; Garg, N.K. Total Synthesis of (-)-N-Methylwelwitindolinone C Isothiocyanate. J. Am. Chem. Soc. 2011, 133, 15797-15799.
2012.6.26@Literature seminar (Ooishi)
Shibasaki, T.; Ooishi, T.; Yamanouchi, N.; Murafuji, T.; Kurotobi, K.; Sugihara, Y. A New Efficient Route to 2-Substituted Azulenes Based on Sulfonyl Group Directed Lithiation. J. Org. Chem. 2008, 73, 7971-7977.
2012.6.12@Literature seminar (Wada)
Uwamori, M.; Saito, A.; Nakada, M. Stereoselective Total Synthesis of Nemorosone. J. Org. Chem. 2012, 77, 5098-5107.
2012.6.7@B4 seminar: Rearrangement reactions.
2012.6.5@Literature seminar (Morioka)
Ishikawa, T.; Kudo, K.; Kuroyabu, K.; Uchida, S.; Kudoh, T.; Saito, S. Domino Double Michael-Claisen Cyclizations: A Powerful General Tool for Introducing Quaternary Stereocenters at C(4) of Cyclohexane-1,3-diones and Total Synthesis of Diverse Families of Sterically Congested Alkaloids. J. Org. Chem. 2008, 73, 7498-7508.
2012.5.31@B4 seminar: elimination reactions.
2012.5.29@Literature seminar (Hata)
Dias, L.C.; Ferreira, M.A.B. Total Synthesis of (-)-Goniotrionin. J. Org. Chem. 2012, 77, 4046-4062.
Many reactions developed by Japanese professors were employed in the construction of the stereochemistry in this total synthesis.
2012.5.26@Guidance for applicants to the 2013 Master's Program. Those who want to apply the program in our laboratory, please send us e-mail.
2012.5.24@B4 seminar: chemistry of carbonyl compounds.
BBQ party in the evening.
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2012.5.22@Literature seminar (Nango)
Qi, X.; Bao, H.; Tambar, U.K. Total Synthesis of (})-Trigonoliimine C via Oxidative Rearrangement of an Unsymmetrical Bis-Tryptamine. J. Am. Chem. Soc. 2011, 133, 10050-10053.
Selective oxidation of 6-methoxyindole was key to complete their total synthesis. It might be difficult to explain why such a selectivity was obtained.
2012.5.21@Solar eclipse in Kobe. Taken with a compact digital camera filtered with a solar shield. |
2012.5.15@Literature seminar (Kojima)
Speranca, A. et al. Regioselective Synthesis of Isochromenones by Iron(III)/PhSeSePh-Mediated Cyclization of 2-Alkynylaryl Esters. J. Org. Chem. 2011, 76, 6789-6797.
2012.5.10@B4 students tackled with difficult organic problems in a seminar
2012.5.10@Launched new website.