原著英文

2021

Inoue H, Asahara S, Sugiura Y, Kawada Y, Imai A, Hara C, Kanno A, Kimura-Koyanagi M, Kido Y. Histone deacetylase 6 regulates insulin signaling in pancreatic beta cells.. Biochem Biophys Res Commun. 534:896-901

Han GR, Takahashi H, Murao N, Gheni G, Yokoi N, Hamamoto Y, Asahara S, Seino Y, Kido Y. Glutamine is an essential mediator in glutamine-amplified insulin secretion.. J.Diab.Invest.12:920-930

Asakawa T, Onizawa M, Saito C, Hikichi R, Yamada D, Minamidate T, Mochimaru T Asahara S, Kido Y, Oshima S, Nagaishi T, Tsuchiya K, Ohira H, OkamotoR, Wataanabe M. Oral administration of d-serine prevents the onset and progression of colitis in mice.. J Gastroenterol.56:732-745

2020

Murata S, Ono R, Yasuda H, Tanemura R, Kido Y, Kowa H. Effect of a combined exercise and cognitive activity intervention on cognitive function in community-dwelling older adults: A pilot randomized controlled trial.. Physical Therapy Research. in press

Asahara S, Miura H, Ogawa W, Tamori Y. Sex difference in the association of obesity with personal or social background among urban residents in Japan. PLoS ONE. in press

Inoue H, Asahara S, Sugiura Y, Kawada Y, Imai A, Hara C, Kanno A, Kimura-Koyanagi M, Kido Y. Histone deacetylase 6 regulates insulin signaling in pancreatic β cells. Biochem. Biophys. Res. Commun. in press

Kanno A, Asahara S, Furubayashi A, Masuda K, Yoshitomi R, Subuki E, Takai T, Koyanagi-Kimura M, Matsuda T, Bartolome A, Hirota Y, Yokoi N, Inaba Y, Inoue H, Matsumoto M, Inoue K, Abe T, Wei F, Tomizawa K,Ogawa W, Seino S, Kasuga M, Kido Y. GCN2 regulates pancreatic β-cell mass by sensing intracellular amino acid levels. JCI Insight.5(9):e128820

Katsuyama A, Kusuhara S, Asahara S, Nakai S, Mori S, Matsumiya W, Miki A, Kurimoto T, Imai H, Kido Y, Ogawa W, Nakamura M. En face slab optical coherence tomography imaging successfully monitors progressive degenerative changes in the innermost layer of the diabect retina. BMJ Open Diabetes Research & Care. 8:e001120

Inoue H, Saito M, Kouchi K, Asahara S, Nakamura F, Kido Y. Association between mean platelet volume in the pathogenesis of type 2 diabetes mellitus and diabetic macrovascular complications in Japanese patients. J. Diab. Invest. 11: 938–945

2019

Kanno A, Asahara S, Kawamura M, Suzuki E, Takai T, Koyanagi-Kimura M, Matsuda T, Okada Y, Ogawa W, Kido Y. Early administration of dapagliflozin preserves pancreatic beta cell mass through a legacy effect in type 2 diabetic mice. J. Diab. Invest. 10:577-590

2018

Yano H, Sakai M, Matsukawa T, Yagi T, Naganuma T, Mitsushima M, Iida S, Inaba Y, Inoue H, Unoki-Kubota H, Kaburagi Y, Asahara S, Kido Y, Minami S, Kasuga M, Matsumoto M.PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes.Sci. Rep. 8: 14290.

Suzuki E, Matsuda T, Kawamoto T, Takahashi H, Mieda Y, Matsuura Y, Takai T, Kanno A, Kimura-Koyanagi M, Asahara S.-i, Inoue H, Ogawa W, Kido Y. Docosahexaenoic acid reduces palmitic acid-induced endoplasmic reticulum stress in pancreatic β cells.Kobe J.Med.Sci. 64:E43-55

Takai T, Matsuda T, Matsuura Y, Inoue K, Suzuki E, Kanno A, Kimura-Koyanagi M, Asahara S.-i, Hatano N, Ogawa W, Kido Y. Casein kinase 2 phosphorylates and stabilizes C／EBPβ in pancreatic β cells. Biochem. Biophys. Res. Commun. 497:451-456

2017

Bartolomé A, García-Aguilar, Asahara S, Kido Y, Guillén C, Pajvani UB, Benito M. MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling. Mol Cell Biol 37:e0044-17

Kawada Y, Asahara S, Sugiura Y, Sato A, Furubayashi A, Kawamura M, Bartolome A, Terashi-Suzuki E, Takai T, Koyanagi-Kimura M, Matsuda T, Hashimoto N, Kido Y. Histone deacetylase regulates insulin signaling via two pathways in pancreatic β cells. PLoS ONE12:e0184435

Watanabe H, Inaba Y, Kimura K, Asahara S, Kido Y, Matsumoto M, Motoyama T, Tachibana N, Kaneko S, Kohno M, Inoue H. Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-induced, Non-alcoholic Fatty Liver Disease. J Nutr 147:52-60

2016

Sakai M, Tsujimura T, Yagi T, Yano H, Mitsushima M, Unoki-Kubota H, Kaburagi Y, Inoue H, Kido Y, Kasuga M, Matsumoto M. The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch. Nat Commun7:13147

Kimura K, Tanida M, Nagata N, Inaba Y, Watanabe H, Nagashimada M, Ota T, Asahara S, Kido Y, Matsumoto M, Toshinai K, Nakazato M, Shibamoto T, Kaneko S, Kasuga M, Inoue H. Centra insulin-action activates Kupffer cells by suppressing hepatic vagal activation through nicotinic alpha 7 acetylcholine receptor. Cell Rep 14:2362-74

2015

Matsuda T, Iwasaki M, Yoshioka N, Hirota Y, Hamaguchi H, Kido Y, Sakaguchi K, Ogawa W. A case of hemiplegia with hypoglycemia possibly associated with hemodynamic change.Diabetol Int. 6: 336-340

Nakarai C, Osawa K, Akiyama M, Matsubara N, Ikeuchi H, Yamano T, Hirota S, Tomita N, Usami M, Kido Y. Expression of AKR1C3 and CNN3 as markers for detection of lymph node metastasis in colorectal cancer. Clin Exp Med 15: 333-341

Asahara S, Etoh H, Inoue H, Teruyama K, Shibutani Y, Ihara Y, Kawada Y, Bartolome A, Hashimoto N, Matsuda T, Koyanagi-Kimura M, Kanno A, Hirota Y, Hosooka T, Nagashima K, Nishimura W, Inoue H, Matumoto M, Higgins MJ, Yasuda K, Inagaki N, Seino S, Kasuga M, Kido Y. Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β cell mass via epigenetic modification of Cdkn1c. Proc Natl Acad Sci USA. 112: 8332-8337

Matsuda T, Takahashi H, Mieda Y, Shimizu S, Kawamoto T, Matsuura Y, Takai T, Suzuki E, Koyanagi-Kimura M, Asahara S, Bartolome A, Yokoi N, Inoue H, Ogawa W, Seino S, Kido Y. Regulation of pancreatic β cell mass by　cross-interaction between CCAAT enhancer binding protein β induced by endoplasmic reticulum stress and AMP-activated protein kinase activity. PLoS ONE. 10: e0130757

Cook JR, Langlet F, Kido Y, Accili D. Pathogenesis of selective insulin resistance in isolated hepatocytes. J Biol. Chem. 290:13972-80

Inaba Y, Furutani T, Kimura K, Watanabe H, Haga S, Kido Y, Matsumoto M, Yamamoto Y, Harada K, Kaneko S, Oyadomari S, Ozaki M, Kasuga M, Inoue H. Growth arrest and DNA damage-inducible 34 regulates liver regeneration in hepatic steatosis in mice. Hepatology 61:1343-56

Kanno A, Asahara S, Masuda K, Matsuda T, Kimura-Koyanagi M, Seino S, Ogawa W, Kido Y. Compensatory hyperinsulinemia in high-fat diet-induced obese mice is associated with enhanced insulin translation in islets. Biochem. Biophys. Res. Commun.  458: 681-686

2014

Bartolomé A, Kimura-Koyanagi M, Asahara S, Guillén C, Inoue H, Teruyama K, Shimizu S, Kanno A, García-Aguilar A, Koike M, Uchiyama Y, Benito M, Noda T, Kido Y. Pancreatic β cell failure mediated by mTORC1 hyperactivity and autophagic impairment. Diabetes 63: 2996-3008

Yoshida Y, Fuchita M, Kimura-Koyanagi M, Kanno A, Matsuda T, Asahara S, Hashimoto N, Isagawa T, Ogawa W, Aburatani H, Noda T, Seino S, Kasuga M, Kido Y．Contribution of insulin signaling to the regulation of pancreatic beta-cell mass during the catch-up growth period in a low birth weight mouse model．Diabetol Int 5: 43-52

2013

Kimura K, Nakamura Y, Inaba Y, Matsumoto M, Kido Y, Asahara S, Matsuda T, Watanabe H, Maeda A, Inagaki F, Mukai C, Takeda K, Akira S, Ota T, Nakabayashi H, Kaneko S, Kasuga M, Inoue H. Histidine augments the suppression of hepatic glucose production by central insulin action.　Diabetes 62: 2266-2277

Shibutani Y, Asahara S, Teruyama K, Inoue H, Matsuda T, Seino S, Kido Y. Constitutive activation of Rac1 in pancreatic β cells facilitates F-actin depolymerization but exerts no influence on the increase of pancreatic β cell mass and facilitation of insulin secretion. Kobe J Med Sci 59:72-80

Asahara S, Shibutani Y, Teruyama K, Inoue H, Kawada Y, Etoh H, Matsuda T, Kimura-Koyanagi M, Hashimoto N, Sakahara M, Fujimoto W, Takahashi H, Ueda S, Hosooka T, Satoh T, Inoue H, Matsumoto M, Aiba A, Kasuga M, Kido Y Rac1 regulates glucose-stimulated insulin secretion via modulation of F-actin. Diabetologia 56:1088-1097

2012

Osawa K, Nakarai C, Akiyama M, Hashimoto R, Tsutou A, Takahashi J, Takaoka Y, Kawamura S, Shimada E, Tanaka K, Kozuka M, Yamamoto M, Kido Y Association between polymorphisms is UDP-glucuronosyltransferase 1A6 and 1A7 and colorectal cancer risk. Asian Pac J Cancer Prev 13: 2311-2314

Nakarai C, Osawa K, Matsubara N, Ikeuchi H, Yamano T, Okamura S, Kamosida S, Tsutou A, Takahashi J, Ejiri K, Hirota S, Tomita N, Kido Y
Significance of ELF3 mRNA expression for detection of lymph node metastasis of colorectal cancer. Anticancer Res 32: 3753-3758

Shimizu S, Hosooka T, Matsuda T, Asahara S, Koyanagi-Kimura M, Kanno A, Bartolome A, Etoh H, Fuchita M, Teruyama K, Takahashi H, Inoue H, Mieda Y, Hashimoto N, Seino S, Kido Y. DPP4 inhibitor vildagliptin preserves beta cell mass through amelioration of ER stress in C/EBPB transgenic mice. J Mol Endocrinol 49:125-135

Takano S, Kaji H, Hayashi F, Higashiguchi K, Joukei S, Kido Y, Takahashi J, Osawa K. A calculation model for serum ionized calcium based on an equilibrium equation for complexation. Analytical Chemistry Insights 7:23-30

Hara K, Yasuda H, Arai T, Miyoshi S, Kubokawa O, Mori H, Akisaki T, Kido Y, Yokono K, Akita H. A case of an elderly patient with slowly progressive type 1 diabetes who developed severe nonocclusive mesenteric ischemia without predisposing events. Internal Medicine51:1065-1068

Sakai M, Matsumoto M, Tsujimura T, Yongheng C, Inagaki K, Yasuda K, Noguchi T, Hosooka T, Inoue H, Takazawa K, Kido Y, Hiramatsu R, Matsuki Y, Kasuga M. CITED2 links hormonal signaling to PGC-1α acetylation in regulation of gluconeogenesis. Nat Med. 18: 612-617

Kimura K, Yamada T, Matusmoto M, Kido Y, Hosooka T, Asahara S, Matsuda T, Ota T, Watanabe H, Sai Y, Miyamoto K, Kaneko S, Kasuga M, Inoue H. Endoplasmic Reticulum Stress Inhibits STAT3-dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation. Diabetes 61:61-73

2011

Koyanagi M, Asahara S, Matsuda T, Hashimoto N, Shigeyama Y, Shibutani Y, Kanno A, Fuchita M, Mikami T, Hosooka T, Inoue H, Matsumoto M, Koike M, Uchiyama Y, Noda T, Seino S, Kasuga M, Kido Y. Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1. PLoS ONE 6: e23238

2010

Osawa K, Miyaishi A, Uchino K, Osawa Y, Inoue N, Nakarai C, Tsutou A, Kido Y, Yoshimura M, Tsubota N, Takahashi J. APEX1 Asp148Glu gene polymorphism is a risk factor for lung cancer in relation to smoking in Japanese. Asian Pac J Cancer Prev 11:1181-1186

Matsuda T, Kido Y, Asahara S, Kaisho T, Tanaka T, Hashimoto N, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M, Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga M. Ablation of C/EBPβ alleviates ER stress and pancreatic β cell failure through the GRP78 chaperone in mice. J. Clin. Invest. 120:115-126

2009

Inoue T, Kido Y, Asahara S, Matsuda T, Shibutani Y, Koyanagi M, Kasuga M. Effect of intrauterine undernutrition during late gestation on pancreatic β cell mass. Biomed. Res.30:325-330

Asahara S, Matsuda T, Kido Y, Kasuga M. Increased ribosomal biogenesis induces pancreatic β cell failure in mice model of type 2 diabetes. Biochem. Biophys. Res. Commun. 381: 367-371

2008

Takeda A, Kido Y, Hashimoto N, Noda T, Kasuga M. Pancreatic β Cell Mass Preserved in Heterozygous PDK1 Knockout Mice. Kobe J Med Sci 54: E183-190

Matsuda T, Kido Y, Uchida T, Kasuga M Reduced insulin signaling and endoplasmic reticulum stress act synergistically to deteriorate pancreatic beta cell function. Kobe J Med Sci 54: E114-121

Shigeyama Y, Kobayashi T, Kido Y, Hashimoto N, Asahara S, Matsuda T, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Uchida T, Inoue M, Hino O, Kasuga M, Noda T Biphasic response of pancreatic β cell mass to ablation of TSC2 in mice. Mol Cell Biol 28:2971-2979

2007

Nakawatase Y, Taru C, Tsutou A, Shiotani H, Kido Y, Ohara T, Ogawa W, Miyawaki I. Development of an evaluation scale for self-management behavior related to physical activity of type 2 diabetic patients. Diabetes Care 30:2843-2848

Kim JJ, Kido Y, Scherer PE, White MF, Accili D. Analysis of compensatory β-cell response in mice with combined mutations of Insr and Irs2. Am J Physiol Endocrinol Metab292:E1694-E1701

Strom A, Bonal C, Ashley-Padan R, Hashimoto N, Campos ML, Trumpp A, Noda T, Kido Y, Real FX, Thorel F, Herrera PL. Unique mechanism of growth regulation and tumor suppression upon Apc inactivation in the pancreas. Development 134:2719-2725

2006

Hashimoto N, Kido Y, Uchida T, Asahara S, Shigeyama Y, Matsuda T, Takeda A, Tsuchihashi D, Nishizawa A, Ogawa W, Fujimoto Y, Okamura H, Arden KC, Herrera PL, Noda T, Kasuga M. Ablation of PDK1 in pancreatic β cells induces diabetes as a result of loss of β-cell mass. Nat. Genet. 38:589-593

2005

Uchida T, Nakamura T, Hashimoto N, Matsuda T, Kotani K, Sakaue H, Kido Y, Hayashi Y, Nakayama KI, White MF, Kasuga M. Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat. Med. 11:175-182

Hashimoto N, Kido Y, Uchida T, Matsuda T, Suzuki K, Inoue H, Matsumoto M, Ogawa W, Maeda S, Fujihara H, Ueta Y, Uchiyama Y, Akimoto K, Ohno S, Noda T, Kasuga M. PKCλ regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic β cells. J. Clin. Invest. 115:138-145

Yutsudo Y, Kido Y, Okabayashi Y, Matsumoto M, Ogawa W, Ohba M, Kuroki T, Kasuga M. Protein kinase Calpha is implicated in cholecystokinin-induced activation of 70-kd S6 kinase in AR42J cells. Pancreas 30:50-53

2004

Inoue H, Ogawa W, Ozaki M, Haga S, Matsumoto M, Furukawa K, Hashimoto N, Kido Y, Mori T, Sakaue H, Teshigawara K, Jin S, Iguchi H, Hiramatsu R, LeRoith D, Takeda K, Akira S, Kasuga M. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nat. Med. 10:168-174

2003

Nogami M, Yamazaki M, Watanabe H, Okabayashi Y, Kido Y, Kasuga M, Sasaki T, Maehama T, Kanaho Y. Requirement of autophosphorylated tyrosine 992 of EGF receptor and its docking phospholipase Cγ1 for membrane ruffle formation. FEBS lett. 536:71-76

Ochi F, Fujii M, Sakai T, Sugano M, Oshiro K, Okabayashi Y, Mita M, Kido Y. A case of acute pancreatitis associated with cationic trypsinogen N29T mutation. Pancreas 27: 199-201

2002

Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs III WH, Wright CW, White MF, Arden KC, Accili D. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth. J. Clin. Invest. 110:1839-1847

Xuan S, Kitamura T, Nakae J, Politi K, Kido Y, Fisher PE, Morroni M, Cinti S, White MF, Herrera PL, Accili D, Efstratiadis A. Defective insulin secretion in pancreaticβcells lacking type 1 IGF receptor. J. Clin. Invest. 110:1011-1019

Kido Y, Nakae J, Hribal ML, Xuan S, Efstratiadis A, Accili D. Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and β-cell compensation to insulin resistance. J. Biol. Chem. 277:36740-36747

Poy MN, Yang Y, Rezaei K, Fernstrom MA, Lee AD, Kido Y, Erickson SK, Najar SM. CEACAM1 regulates insulin clearance in liver. Nat. Genet. 30:270-276

2001

Kitamura T, Kido Y, Nef S, Merenmies J, Parada LF, Accili D. Preserved Pancreatic beta-Cell Development and Function in Mice Lacking the Insulin Receptor-Related Receptor. Mol. Cell. Biol. 21:5624-5630

Kim JJ, Park BC, Kido Y, Accili D. Mitogenic and Metabolic Effects of Type I IGF Receptor Overexpression in Insulin Receptor-Deficient Hepatocytes. Endocrinology 142:3354-3360

2000

Kido Y, Philippe N, Schaffer AA, Accili D. Genetic modifiers of the insulin resistance phenotype in mice. Diabetes 49:589-596

Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, Accili D. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J. Clin. Invest. 105:199-205