神戸大学バイオシグナル総合研究センター 細胞情報研究分野 | 吉川研究室

研究業績

2021

  1. Kano, T., Tsumagari, R., Nakashima, A., Kikkawa, U., Ueda, S., Yamanoue, M., Takei, N., Shirai, Y.
    RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth.
    Biomolecules 11, 1814 (2021), PubMed PMID: 34944458
    PubMed
    2. Open access
  2. Matsuda, S., Kikkawa, U., Nakashima, A.
    The S. pombe CDK5 Orthologue Pef1 Cooperates with Three Cyclins, Clg1, Pas1 and Psl1, to Promote Pre-Meiotic DNA Replication.
    Biomolecules 11, 89, (2021), PubMed PMID: 33445784
    PubMed
    3. Open access
  3. Nagano, T., Iwasaki, T., Onishi, K., Awai, Y., Terachi, A., Kuwaba, S., Asano, S., Katasho, R., Nagai, K., Nakashima, A., Kikkawa, U., Kamada, S.
    LY6D-induced macropinocytosis as a survival mechanism of senescent cells.
    J Biol Chem. 296, 100049, (2021), PubMed PMID: 33410404
    PubMed
    4. Open access

2020

  1. Matsuda, S., Kikkawa, U., Uda, H., Nakashima, A.
    The S. pombe CDK5 ortholog Pef1 regulates sexual differentiation through control of the TORC1 pathway and autophagy.
    J Cell Sci. 133, (2020):jcs247817. PubMed PMID: 32788233
    PubMed
    2. Open access
  2. Nakai, H., Tsumagari, R., Maruo, K., Nakashima, A., Kikkawa, U., Ueda, S., Yamanoue, M., Saito, N., Takei, N., Shirai, Y.
    mTORC1 is involved in DGKβ-induced neurite outgrowth and spinogenesis.
    Neurochem Int. 134, 104645. (2020), PubMed PMID: 31891737
    PubMed

2019

  1. Suda, K., Kaneko, A., Shimobayashi, M., Nakashima, A., Tatsuya, M., Hall, M.N., Ushimaru, T.
    TORC1 regulates autophagy induction in response to proteotoxic stress in yeast and human cells.
    Biochem Biophys Res Commun. 511, 434-439 (2019), PubMed PMID: 30797551
    PubMed
  2. Nagano, T., Yamao, S., Terachi, A., Yarimizu, H., Itoh, H., Katasho, R., Kawai, K., Nakashima, A., Iwasaki, T., Kikkawa, U., Kamada, S.
    D-amino acid oxidase promotes cellular senescence via the production of reactive oxygen species.
    Life Sci. Alliance 2, pii: e201800045. (2019), PubMed PMID: 30659069
    PubMed
    3. Open access

2018

  1. Kikkawa, U.
    The story of PKC: A discovery marked by unexpected twists and turns.
    IUBMB Life, Nov 4, (2018), PubMed PMID: 30393952
    PubMed
  2. Sawa, R., Nishida, H., Yamamoto, Y., Wake, I., Kai, N., Kikkawa, U., Okimura, Y.
    Growth hormone and Insulin-like growth factor-I (IGF-I) modulate the expression of L-type amino acid transporters in the muscles of spontaneous dwarf rats and L6 and C2C12 myocytes.
    Growth Horm IGF Res. 42-43, 66-73 (2018), PubMed PMID: 30273774
    PubMed

2017

  1. Otsubo, Y., Nakashima, A., Yamamoto, M., Yamashita, A.
    TORC1-Dependent Phosphorylation Targets in Fission Yeast.
    Biomolecules 7, pii:E50.(2017), PubMed PMID: 28671615
    PubMed
    Open access
  2. Nagano, T., Nakashima, A., Onishi, K., Kawai, K., Awai, Y., Kinugasa, M., Iwasaki, T., Kikkawa, U., Kamada, S.
    Proline dehydrogenase promotes senescence through the generation of reactive oxygen species.
    J Cell Sci. 130, 1413-1420 (2017), PubMed PMID: 28264926
    PubMed

2016

  1. Nagano, T., Nakano, M., Nakashima, A., Onishi, K., Yamao, S., Enari, M., Kikkawa, U., Kamada, S.
    Identification of cellular senescence-specific genes by comparative transcriptomics.
    Sci Rep. 6, 31758 (2016), PubMed PMID: 27545311
    PubMed
    Free Article
  2. Kozel, C., Thompson, B., Hustak, S., Moore, C., Nakashima, A., Singh, C.R., Reid, M., Cox, C., Papadopoulos, E., Luna, R.E., Anderson, A., Tagami, H., Hiraishi, H., Slone, E.A., Yoshino, KI., Asano, M., Gillaspie, S., Nietfeld, J., Perchellet, J.P., Rothenburg, S., Masai, H., Wagner, G., Beeser, A., Kikkawa, U., Fleming, S.D., Asano, K.
    Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation.
    Nucleic Acids Res. pii: gkw559 (2016), PubMed PMID: 27325740.
    PubMed
  3. Ma, N., Ma, Y., Nakashima, A., Kikkawa, U, Furuyashiki, T.
    The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast.
    PLoS One 11, e0156239 (2016), PubMed PMID: 27227887
    PubMed
    Free Article
  4. Matsunaga, R., Nishino, T., Yokoyama, A., Nakashima, A., Kikkawa, U., and Konishi, H.
    Versatile function of the circadian protein CIPC as a regulator of Erk activation.
    Biochem Biophys Res Commun. 469, 377-383 (2016), PubMed PMID: 26657846
    PubMed

2015

  1. Kawai, M., Nakashima, A., Kamada, S., and Kikkawa, U. Midostaurin preferentially attenuates proliferation of triple-negative breast cancer cell lines through inhibition of Aurora kinase family.
    J. Biomed. Sci. 22, 48 (2015), PubMed PMID: 26141684
    PubMed
    Free Article

2014

  1. Nakashima, A., Kamada, S., Tamanoi, F., and Kikkawa, U.
    Fission yeast arrestin-related trafficking adaptor, Arn1/Any1, is ubiquitinated by Pub1 E3 ligase and regulates endocytosis of Cat1 amino acid transporter.
    Biol. Open 3, 542-552 (2014)
    PubMed
    Free Article
  2. Santiago, Lima A.J., Hoogeveen-Westerveld, M., Nakashima, A., Maat-Kievit, A., van den Ouweland, A., Halley, D., Kikkawa, U., and Nellist, M.
    Identification of regions critical for the integrity of the TSC1-TSC2-TBC1D7 complex.
    PLoS One 9, e93940 (2014)
    PubMed
    Free Article
  3. Ooi, E.L., Chan, S.T., Cho, N.E., Wilkins, C., Woodward, J., Li, M., Kikkawa, U., Tellinghuisen, T., Gale, M. Jr, and Saito, T.
    Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.
    Proc Natl Acad Sci U S A. 111, 1909-1914 (2014)
    PubMed

2013

  1. Nakano, M., Nakashima, A., Nagano, T., Ishikawa, S., Kikkawa, U., and Kamada, S.
    Branched-Chain Amino Acids Enhance Premature Senescence through Mammalian Target of Rapamycin Complex I-Mediated Upregulation of p21 Protein.
    PLoS One 8, e80411 (2013)
    PubMed
    Free Article
  2. Nakashima, A., Tanimura-Ito, K., Oshiro, N., Eguchi, S., Miyamoto, T., Momonami, A., Kamada, S., Yonezawa K., and Kikkawa, U.
    A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A.
    FEBS Lett. 587, 2924-2929 (2013)
    PubMed
  3. Nagano, T., Hashimoto, T., Nakashima, A., Hisanaga, S., Kikkawa, U., and Kamada, S.
    Cyclin I is involved in the regulation of cell cycle progression.
    Cell Cycle 12, 2617-2624 (2013)
    PubMed
  4. Nakashima, A., Kawanishi I, Eguchi S, Yu EH, Eguchi S, Oshiro N, Yoshino K, Kikkawa, U., and Yonezawa K.
    Association of CAD, a multifunctional protein involved in pyrimidine synthesis, with mLST8, a component of the mTOR complexes.
    J. Biomed. Sci. 20, 24 (2013)
    PubMed

2012

  1. Nakashima, A., Otsubo, Y., Yamashita, A., Sato, T., Yamamoto, M., and Tamanoi, F.
    Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase.
    J. Cell Sci. 125, 5840-5849 (2012)
    PubMed
  2. Chan, S.H., Kikkawa, U., Matsuzaki, H., Chen, J.H., and Chang, W.C.
    Insulin receptor substrate-1 prevents autophagy-dependent cell death caused by oxidative stress in mouse NIH/3T3 cells.
    J. Biomed. Sci. 19, 64 (2012)
    PubMed
    Free Article
  3. Nagano, T., Hashimoto, T., Nakashima, A., Kikkawa, U. and Kamada, S.
    X-linked inhibitor of apoptosis protein mediates neddylation by itself but does not function as a NEDD8-E3 ligase for caspase-7.
    FEBS Lett. 586, 1612-1616 (2012)
    PubMed
  4. Hashimoto, T., Juso, K., Nakano, M., Nagano, T., Kambayashi, S., Nakashima, A., Kikkawa, U. and Kamada, S.
    Preferential Fas-mediated apoptotic execution at G1 phase: the resistance of mitotic cells to the cell death.
    Cell Death Dis. 3, e313 (2012)
    PubMed
    Free Article
  5. Fujiwara, T., Fukao, A., Sasano, Y., Matsuzaki, H., Kikkawa, U., Imataka, H., Inoue, K., Endo, S., Sonenberg, N., Thoma, C., and Sakamoto, H.
    Functional and direct interaction between the RNA binding protein HuD and active Akt1.
    Nucleic Acids Res. 40 (5), 1944-1953 (2012)
    PubMed

2011

  1. Hashimoto, T., Kikkawa, U. and Kamada, S.
    Contribution of caspase(s) to the cell cycle regulation at mitotic phase.
    PLoS ONE 6, e18449 (2011)
    PubMed
    Free Article

2010

  1. Nakashima, A., and Tamanoi, F.
    Conservation of the Tsc/Rheb/TORC1/S6K/S6 signaling in fission yeast.
    The Enzymes 28, 167-187 (Chapter 8) (2010)
  2. Jiang, H., Song, C., Chen, C. C., Xu, R., Raines, K. S., Fahimian, B. P., Lu, C. H., Lee, T. K., Nakashima, A., Urano, J., Ishikawa, T., Tamanoi, F., and Miao, J.
    Quantitative 3D imaging of whole, unstained cells by using X-ray diffraction microscopy.
    Proc. Natl. Acad. Sci. USA 107, 11234-11239 (2010).
    PubMed
  3. Kaizuka, T., Hara, T., Oshiro, N., Kikkawa, U., Yonezawa, K., Takehana, K., Iemura, S.I., Natsume, T., and Mizushima, N.
    Mammalian Tti1 and Tel2 are critical factors in mTOR complex assembly.
    J. Biol. Chem. 285, 20109-20116 (2010)
    PubMed
  4. Sato, T., Nakashima, A., Guo, L., Coffman, K., and Tamanoi, F.
    Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer.
    Oncogene 29, 2746-2752 (2010)
    PubMed
  5. Nakashima, A., Sato, T., and Tamanoi, F.
    Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.
    J. Cell Sci. 123, 777-786 (2010)
    PubMed
  6. Oka, M., Sakaguchi, M., Okada, T., Nagai, H., Ozaki, M., Yoshioka, T., Inoue, H., Mukaida, N., Kikkawa, U., and Nishigori C.
    Signal transducer and activator of transcription 3 upregulates interleukin-8 expression at the level of transcription in human melanoma cells.
    Exp Dermatol. 19, e50-e55 (2010)
    PubMed

2009

  1. Avruch, J., Long, X., Lin, Y., Ortiz-Vega, S., Rapley, J., Papageorgiou, A., Oshiro, N. and Kikkawa, U.
    Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor.
    Biochem. Soc. Trans. 37, 223-226 (2009)
    PubMed
  2. Eguchi, S., Oshiro, N., Miyamoto, T., Yoshino, K., Okamoto, S., Ono, T., Kikkawa, U. and Yonezawa, K.
    AMP-activated protein kinase phosphorylates glutamine:fructose-6-phosphate amidotransferase 1 at Ser243 to modulate its enzymatic activity.
    Genes Cells 14, 179-189 (2009)
    PubMed
  3. Sato, T., Nakashima, A., and Tamanoi, F.
    Specific activation of mTORC1 by RHEB G-protein in vitro involves enhanced recruitment of its substrate protein.
    J Biol. Chem. 284, 12783-12791 (2009)
    PubMed

2008

  1. Nakashima, A., Maruki, Y., Imamura, Y., Kondo, C., Kawamata, T., Kawanishi, I., Takata, H., Matsuura, A., Lee, K.S., Kikkawa, U., Ohsumi, Y., Yonezawa, K. and Kamada, Y.
    The yeast Tor signaling pathway is involved in G2/M transition via polo-kinase.
    PLoS ONE 3, e2223 (2008)
    PubMed
  2. Hashimoto, T., Yamauchi, L., Hunter, T., Kikkawa, U. and Kamada, S.
    Possible involvement of caspase-7 in cell cycle progression at mitosis.
    Genes Cells 13, 609-621 (2008)
    PubMed
  3. Huang, C.C, Wang, J.M., Kikkawa, U., Mukai, H., Chen, B.K., Shen, M.R., and Chang, W.C.
    Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation.
    Oncogene 27, 2422-2429 (2008)
    PubMed
  4. Miyamoto, T., Oshiro, N., Yoshino, K., Nakashima, A., Eguchi, S., Takahashi, M., Ono, Y., Kikkawa, U., and Yonezawa, K.
    AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatus.
    J. Biol. Chem. 283, 4430-4438 (2008)
    PubMed
  5. Oka, M., Kikkawa, U., and Nishigori, C.
    Protein kinase C-βII represses hepatocyte growth factor-induced invasion by preventing the association of adapter protein Gab1 and phosphatidylinositol 3-kinase in melanoma cells.
    J. Invest. Dermatol. 128, 188-195 (2008)
    PubMed

2007

  1. Morita, M., Matsuzaki, H., Yamamoto, T., Fukami, Y., and Kikkawa, U.
    Epidermal growth factor receptor phosphorylates protein kinase C δ at Tyr332 to form a trimeric complex with p66Shc in the H2O2-stimulated cells.
    J. Biochem. 143, 31-38 (2007)
    PubMed
  2. Nakashima, A., Yoshino, K., Miyamoto, T., Eguchi, S., Oshiro, N., Kikkawa, U., and Yonezawa, K.
    Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complex.
    Biochem. Biophys. Res. Commun. 361, 218-223 (2007)
    PubMed
  3. Oshiro, N., Takahashi, R., Yoshino, K., Tanimura, K., Nakashima, A., Eguchi, S., Miyamoto, T., Hara, K., Takehana, K., Avruch, J., Kikkawa, U., and Yonezawa, K.
    The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.
    J. Biol. Chem. 282, 20329-20339 (2007)
    PubMed
  4. Chen, B.K., Huang, C.C., Chang, W.C., Chen, Y.J., Kikkawa, U., Nakahama, K.I., Morita I., and Chang, W.C.
    PP2B-mediated dephosphorylation of c-Jun C-terminus regulates phorbol ester-induced c-Jun/Sp1 interaction in A431 cells.
    Mol. Biol. Cell 18, 1118-1127 (2007)
    PubMed
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