名称 著者

Determining fluoride in salts using capillary zone electrophoresis with transient isotachophoresis, Salt and Seawater Science & Technology, 2, 10-16


Fukushi,K., Tsujimoto, J., Hotta, H., Okamura, H., Inui, H.

Simple monitoring of endocrine-disrupting chemicals using transgenic Arabidopsis plants expressing medaka estrogen receptor, Chemosphere, 286, 131633


Stoykova, P., Ohkawa, H., Inui, H.




Functional reconstitution of dopamine D2 receptor into a supported model membrane in a nanometric confinement,Adv. Biology , 5, In press


Nagai, R., Sugimachi, A., Tanimoto, Y., Suzuki, K. G. N., Hayashi, F., Kasai, R. S., Morigaki, K.

パターン化人工膜への膜タンパク質の再構成,電気学会論文誌C, 263, In press


永井るりか, 杉町純音, 谷本泰士, 鈴木健一, 林文夫, 笠井倫志, 森垣憲一

Transport enhancement of hydrophobic pollutants by the expression of zucchini major latex-like protein genes in tobacco plants, Journal of Plant Physiology, 263, 153464


Stoykova, P., Inui, H.

アクアフォトミクスによる環境・作物汚染の非破壊適時診断法, 化学工業, Vol.72, No.8, pp.566-570


乾秀之、エレナ ムンカン、ペティア ストイコヴァ、ルミアナ ツェンコヴァ

How does the Cucurbitaceae family take up organic pollutants (POPs, PAHs, and PPCPs)?, Reviews in Environmental Science and Bio/Technology, 20(3), 751-779


Fujita, K., Inui, H.

Biological functions of major latex-like proteins in plants, Plant Science, 306, 110856


Fujita, K., Inui, H.

光重合性リン脂質と天然リン脂質を組み合わせたパターン化人工膜による生体膜機能の再構成と応用, , 46 (2), 65-70



Model lipid membranes assembled from natural plant thylakoids into 2-D microarray patterns as a platform to assess the organization and photophysics of light-harvesting proteins, Small , 17, 2006608


Meredith, S. A., Yoneda, T., Hancock, A. M., Connell, S. D., Evans, S. D., Morigaki, K., Adams, P. G.

Substrate-supported model membrane as a versatile analytical/ biosensing platform, Anal. Sci., 37, 683-689


Morigaki, K.

Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson’s disease, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 158858


Ami Oguro, Yasuhiro Ishihara, Ferbian Milas Siswanto,Takeshi Yamazaki, Atsuhiko Ishida, Hiromasa Imaishi, Susumu Imaoka

New lipid membrane technologies for reconstitution, analysis, and utilization of 'living' membrane proteins, Biophys. Physicobiol. 17 ,125-129


Yasuhara, K., Morigaki, K.

Inhibitory effects of type 2 diabetes serum components in P450 inhibition assays can potential diagnose asymptomatic diabetic mice, Drug Metabolism and Pharmacokinetics, 35(6), 497-504


Tamaki, S., Imaishi H.

Suppression of the genes responsible for transporting hydrophobic pollutants leads to the production of safer crops, Science of the Total Environment, 741, 140439


Fujita, K., Haga, Y., Yoshihara, R., Matsumura, C., Inui, H.

Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins, Environmental Pollution, 266, 115179


Fujita, K., Kondoh, Y., Honda, K., Haga, Y., Osada, H., Matsumura, C., Inui, H.

The effects of phospholipids and fatty acids on the oligomer formation of NAP-22, Neurosci. Lett., 736, 135288


Odagaki, S.-I., Maekawa, S., Hayashi, F., Suzaki, T., Morigaki, K.

Detoxification of Aflatoxin B1 contaminated maize using human CYP3A4, Jounal of Microbiology and Biotechnology, 30(8), 1207-1213


Marie Yamada, Koji Hatsuta, Mayuko Niikawa, and Hiromasa Imaishi

Photosynthetic model membranes of natural plant thylakoid embedded in a patterned polymeric lipid bilayer, Langmuir, 36, 5863-5871


Yoneda, T., Tanimoto, Y., Takagi, D., Morigaki, K.

Efficient biodegradation of petroleum n-alkanes and polycyclic aromatic hydrocarbons by polyextremophilic Pseudomonas aeruginosa san ai with multidegradative capacity, RSC Advances, 10, 14060-14070


Medic, A., Ljesevic, M.,Inui, H., Beškoski, V., Kojic, I., Stojanovic, K., Karadzic, I.

Effects of Arabidopsis Ku80 deletion on the integration of the left border of T-DNA into plant chromosomal DNA via Agrobacterium tumefaciens, Genes and Genetic Systems, 95, 1-10


Yoshihara, R., Mitomi, Y., Okada, M., Shibata, H., Tanokami, M., Nakajima, Y., Inui, H., Oono, Y., Furudate, H., Tanaka, S.

Affinity of rhodopsin to raft enables the aligned oligomer formation from dimers: Coarse-grained molecular dynamics simulation of disk membranes, PLoS One, 15(2), e0226123


Kaneshige, Y., Hayashi, F., Morigaki, K., Tanimoto, Y., Yamashita, H., Fuji, M., Awazu, A.

High temperatures promote the uptake of hydrophobic pollutants by Cucurbita pepo via altered gene expression levels of major latex-like proteins, Journal of Pesticide Science, 45, 75-80


Inui, H., Katte, N., Goto, J., Iwabuchi, A.

Factors regulating the differential uptake of persistent organic pollutants in cucurbits and non-cucurbits, Journal of Plant Physiology, 245, 153094


Iwabuchi, A., Katte, N., Suwa, M., Goto, J., Inui, H.

Self-spreading of phospholipid bilayer in a patterned framework of polymeric bilayer, Langmuir, 35, 14696-14703

2019年 Tamura, F., Tanimoto, Y., Nagai, R., Hayashi, F., Morigaki, K.

Alteration of membrane physicochemical properties by two factors for membrane protein integration, Biophys. J., 117 (1), 99-110

2019年 Nomura, K., Yamaguchi, T., Mori, S., Fujikawa, K., Nishiyama, K., Shimanouchi, T., Tanimoto, Y., Morigaki, K., Shimamoto, K.

Raftophilic rhodopsin clusters offer stochastic platforms for G protein signalling in retinal discs, Communications Biology, 2, 209

2019年 Hayashi, F., Saito, N., Tanimoto, Y., Okada, K., Morigaki, K., Seno, K., Maekawa, S.

パターン化人工膜を用いた生体膜機能の解析, 生物物理, 59, 4, 188-191

2019年 森垣憲一

Uptake mechanisms of polychlorinated biphenyls in Cucurbita pepo via xylem sap containing major latex-like proteins, Environmental and Experimental Botany, 162, 399-405

2019年 Goto, J., Iwabuchi, A., Yoshihara, R., Kodama, N., Matsui, T., Hirota, M., Eun, E., Inui, H.

Physiological role of β-carotene monohydroxylase (CYP97H1) in carotenoid biosynthesis in Euglena gracilis, Plant Sci., 278, 80-87

2019年 Tamaki S, Kato S, Shinomura T, Ishikawa T, Imaishi H.

Nanofluidic biosensor created by bonding patterned model cell membrane and silicone elastomer with silica nanoparticles, Small, 14 (49), 1802804

2018年 Tanabe, M., Ando, K., Komatsu, R., Morigaki, K.

真核光合成生物におけるシトクロムP450型カロテン水酸化酵素 (CYP97)の機能解析, BSJ-review , 9, 80-89

2018年 玉木峻, 今石浩正

Metabolism of steroids by cytochrome P450 2C9 variants, Biopharm Drug Dispos., 39, 371-377

2018年 Uno T, Nakano R, Kitagawa R, Okada M, Kanamaru K, Takenaka S, Uno Y, Imaishi H.

Defluorination of perfluoroalkyl acids is followed by production of monofluorinated fatty acids, Science of the Total Environment, 636, 355-35

2018年 Beškoski, P.V., Yamamoto, A., Nakano, T., Yamamoto, K., Matsumura, C., Motegi, M., Be?koski, L., Inui, H.

Metabolic enhancement of 2,3’,4,4’,5-pentachlorobiphenyl (CB118) using cytochrome P450 monooxygenase isolated from soil bacterium under the presence of perfluorocarboxylic acids (PFCAs) and the structural basis of its metabolism, Chemosphere, 210, 376-383

2018年 Goto, E., Haga, Y., Kubo, M., Itoh, T., Kasai, C., Shoji, O., Yamamoto, K., Matsumura, C., Nakano, T., Inui, H.

Serum derived from ulcerative colitis mouse changes the metabolism of the fluorescent substrate by P450 depending on the degree of disease progression, Chem Biol Interact., 290, 88-98

2018年 Yamamoto R., Muroi K., Imaishi H.

Evolution and development of model membranes for physicochemical and functional studies of the membrane lateral heterogeneity, Biochim. Biophys. Acta - Biomembranes, 1860, 2012-2017

2018年 Morigaki, K., Tanimoto, Y.

Capillary zone electrophoresis determination of fluoride in seawater using transient isotachophoresis, Analytical and Bioanalytical Chemistry, 410, 1825-1831

2018年 Fukushi, K., Fujita, Y., Nonogaki, J., Tsujimoto, J-i., Hattori,, T., Inui, H., Beškoski, V. P., Hotta, H., Hayashi, M., Nakano, T.

Modification of N-terminal amino acids of fungal benzoate hydroxylase (CYP53A15) for the production of p-hydroxybenzoate and optimization of bioproduction conditions in Escherichia coli, J. Microbiol. Biotech., 28(3),439-447

2018年 Tamaki S.,Yagi M., Nishihata, Y., Yamaji, H., Shigeri, Y., Uno, T., Imaishi H.

Effect of genetic polymorphism of human CYP2B6 on the metabolic activation of chlorpyrifos, Pesticide Biodhemistry and Physiology, 144, 42-48

2018年 Imaishi H., Goto T.

Metabolism of 7-ethoxycoumarin, flavanone and steroids by cytochrome P450 2C9 variants pollutants, Biopharm Drug Dispos, 38(8), 486-493

2017年 Uno T, Nakano R, Kanamaru K, Takenaka S, Uno Y, Imaishi H.

Molecular insights into the role of a distal F240A mutation that alters CYP1A1 activity towards persistent organic pollutants, Biochimica et Biophysica Acta General Subjects, 1861, 2852-2860

2017年 Navrátilová, V., Paloncýová, M., Berka, K., Mise, S., Haga, Y., Matsumura, C., Sakaki, T., Inui, H., Otyepka, M.

ズッキーニの憂鬱, 生物工学会誌 , 95, 270

2017年 乾秀之

Hybrid model membrane combining micropatterned lipid bilayer and hydrophilic polymer brush, Langmuir, 33, 5752-5759

2017年 Nishimura, T., Tamura, F., Kobayashi, S., Tanimoto, Y., Hayashi, F., Sudo, Y., Iwasaki, Y., Morigaki, K.

Raft-based sphingomyelin interactions revealed by new fluorescent sphingomyelin analogs, J. Cell Biol, 168, 1183-1204

2017年 Kinoshita, M., Suzuki, K., Matsumori, N., Takada, M., Ano, H., Morigaki, K., Abe, M., Makino, A., Kobayashi, T., Hirosawa, K., Fujiwara, T., Kusumi, A., Murata, M.

Distribution of perfluoroalkyl compounds in Osaka Bay and coastal waters of Western Japan, Chemosphere, 170, 260-265

2017年 Beskoski, P.V., Yamamoto, K., Yamamoto, A., Okamura, H., Hayashi, M., Nakano, T., Matsumura, C., Fukushi, K., Wada, S., Inui, H.

The role of the Prod1 membrane anchor in newt limb regeneration, Angew. Chem. Int. Ed. 56, 270-274

2017年 Nomura, K., Tanimoto, Y., Hayashi, F., Harada, E., Shan, X.-Y., Shionyu, M., Hijikata, A., Shirai, T., Morigaki, K., Shimamoto, K.

Functional characterization of CYP52G3 from Aspergillus oryzae and its application for bioconversion and synthesis of hydroxyl flavanone and steroids, Biotechnol. Appl. Biochem. 64, 385-391

2017年 Uno T., Yanase T., Imaishi H.

Nanometric gap structure with fluid lipid bilayer for the selective transport and detection of biological molecules, Langmuir 32, 7958-7964

2016年 Ando, K., Tanabe, M., Morigaki, K.

Structural determinants of the position of 2,3’,4,4’,5-pentachlorobiphenyl (CB118) hydroxylation by mammalian cytochrome P450 monooxygenases, Toxicological Sciences, 152 (2), 340-348

2016年 Mise, S., Haga, Y., Itoh, T., Kato, A., Fukuda, I., Goto, E., Yamamoto, K., Yabu, M., Matsumura, C., Nakano, T., Sakaki, T., Inui, H.

パターン化脂質膜を基盤とした人工生体膜の創出, 表面科学, (accepted)

2016年 森垣憲一

光重合性脂質を用いたパターン化モデル生体膜の創製, 高分子, 64(10), 653-654

2015年 森垣憲一

Evaluating the raftophilicity of rhodopsin photoreceptor in a patterned model membrane damage, Biophys. J., 109 (11), 2309-2316

2015年 Tanimoto, Y., Okada, K., Hayashi, F., Morigaki, K.

Uptake of raft components into amyloid beta-peptide aggregates and membrane damage, Anal. Biochem, 481 (1), 18-26

2015年 Sasahara, K., Morigaki, K., Mori, Y.

Functional Characterization of CYP1A9 and CYP1C1 from Anguillus japonica, Environmen. Toxicol. Pharmacol, 40(2):360-8

2015年 Uno, T., Izumi, C., Takenaka, S., Yanase, T., Imaishi, H., Kanamaru, K., Yamagata, H., Kaminishi Y., Itakura T.

Point mutation of cytochrome P450 2A6 (a polymorphic allele CYP2A6.25) confers new substrate specificity towards flavonoids, Biopharm. Drug Dispos, 36 (8), 552–563

2015年 Uno, T., Ogura, C., Izumi, C., Nakamura, M., Yanase, T., Yamazaki, H., Ashida, H., Kanamaru, K., Yamagata, H., Imaishi, H.

Poly(dimethylsiloxane) (PDMS) surface patterning by biocompatible photo-crosslinking block copolymers, RSC Adv. , 5, 46686-46693

2015年 Kuroda, K., Miyoshi, H., Fujii, S., Hirai, T., Takahara, A., Nakao, A., Iwasaki, Y., Morigaki, K., Ishihara, K., Yusa, S.

Different uptake pathways between hydrophilic and hydrophobic compounds in lateral roots of Cucurbita pepo, Journal of Pesticide Science, 40(3), 99-105

2015年 Yamazaki, K., Tsuruta, H. and Inui, H.

Micropatterned model membrane with quantitatively controlled separation of lipid phases, RSC Adv. , 5, 1507-1513

2015年 Okada, F., Morigaki, K.

Zinc finger protein genes from Cucurbita pepo are promising tools for conferring non-Cucurbitaceae plants with ability to accumulate persistent organic pollutants, Chemosphere, 123, 48-54

2015年 Inui, H., Hirota, M., Goto, J., Yoshihara, R., Kodama, N., Matsui, T., Yamazaki, K., Eun, H.

Metabolism of agrochemicals and related environmental chemicals based on cytochrome P450s in mammals and plants, Pest Management Science, 71(6), 824-828

2015年 Ohkawa, H., Inui, H.

「固体基板表面に形成された人工生体膜の特性と応用展開」,生物模倣技術と新材料・新製品開発への応用 下村政嗣(編), 技術情報協会

2014年 森垣憲一

Effect of amending soil with organic acids on perylene uptake into Cucurbita pepo, Journal of Pesticide Science, 39(3), 162-164

2014年 Yoshihara, R., Matsuo, S., Iwata, T., Inui, H.

Mammalian cytochrome P450-dependent metabolism of polychlorinated dibenzo-p-dioxins and coplanar polychlorinated biphenyls, International Journal of Molecular Sciences, 15(8), 14044-14057

2014年 Inui, H., Itoh, T., Yamamoto, K., Ikushiro, S.-I., Sakaki, T.

Amyloid aggregation and deposition of human islet amyloid polypeptide at membrane interfaces, FEBS J., 281, 2597-2612

2014年 Sasahara, K., Morigaki, K., Shinya, K.

Preparation of calcium carbonate microparticles containing organic fluorescent molecules from vaterite, Adv. Powder Technol., 25, 1147-1154

2014年 Fujiwara, M., Shiokawa, K., Kubota, T., Morigaki, K.

Parallel assay of inkjet-printed cytochrome P450, Anal. Methods, 6, 2117-2124

2014年 Kanemura, E., Goto, T., Tatsu, Y., Imaishi, H., Morigaki, K.

Molecular mechanisms of herbicide-inducible gene expression of tobacco CYP71AH11 metabolizing the herbicide chlorotoluron, Pesticide Biochemistry and Physiology, 108, 49-57

2014年 Gion, K., Inui, H., Takakuma, K., Yamada, T., Kambara, Y., Nakai, S., Fujiwara, H., Miyamura, T., Imaishi, H., Ohkawa, H.

Discharge of perfluorinated compounds from rivers and their influence on the coastal seas of Hyogo prefecture, Japan., Environmental Pollution, 184, 397-404

2014年 Takemine,S., Matsumura,C., Yamamoto,K., Suzuki,M., Tsurukawa,M., Imaishi, H.,Nakano,T., Kondo,A.

Predicting Toxicity of Food-Related Compounds Using Fuzzy Decision Trees , International Journal of Bioscience, Biochemistry and Bioinformatics, 4(1), 33-38

2013年 Yajima, D., Ohkawa, T., Muroi, K., Imaishi, H.

Microarrays of phospholipid bilayers generated by inkjet-printing, Langmuir, 29, 6404-6408

2013年 Yamada, M., Imaishi, H., Morigaki, K.

A major latex-like protein is a key factor in crop contamination by persistent organic pollutants, Plant Physiology, 161, 2128-2135

2013年 Inui, H., Sawada, M., Goto, J., Yamazaki, K., Kodama, N., Tsuruta, H., Eun, H.

Effects of membrane interaction and aggregation of amyloid b-peptide on lipid mobility and membrane domain structure, Phys. Chem. Chem. Phys., 15, 8929-8939

2013年 Sasahara, K., Morigaki, K., Shinya, K.

Surface functionalization of a polymeric lipid bilayer for coupling a model biological membrane with molecules, cells, and microstructures, Langmuir, 29, 2722-2730

2013年 Morigaki, K., Mizutani, K., Saito, M., Okazaki, T., Nakajima, Y., Tatsu, Y. Imaishi, H.

Selective uptake of polychlorinated biphenyls by Cucurbita pepo, Organohalogen Compounds, 74, 1213-1216

2012年 Inui, H., Yamazaki, K., Matsuo, S., Yoshihara, R., Eun, H.

Functional analysis of the biological membrane by using a substrate-supported model membrane, Membrane, 37, 276-281

2012年 Morigaki, K.

Binding of islet amyloid polypeptide to supported lipid bilayers and amyloid aggregation at the membranes, Biochemistry, 51, 6908-6919

2012年 Sasahara, K., Morigaki, K., Okazaki, T., Hamada, D.

Localized surface plasmon microscopy of submicron domain structures of mixed lipid bilayers, Biomed. Opt. Express, 3, 2012-2020

2012年 Watanabe, K., Miyazaki, R., Terakado, G., Okazaki, T., Morigaki, K., Kano, H.

Metabolism of 7-ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants., Biopharm. Drug Dispos., 34 (2), 87-97

2012年 Uno, T., Obe, Y., Ogura, C., Goto, T., Yamamoto, K., Nakamura, M., Kanamaru, K., Yamagata, H., Imaishi, H.

Investigation of environmental contaminationof mono-isopropylnaphthalene, di-isopropylnaphthalene and tri-isopropylnaphthalene in Hyogo in Japan, Environmental Science and Pollution Research, 19, 3959-68

2012年 Suzuki, M,. Matsumura,C,. Nakano,T,. Imaishi, H.

Formation of substrate supported membranes from mixtures of long and short chain phospholipids, Langmuir, 28, 9649−9655

2012年 Morigaki, K., Kimura, S., Okada, K., Kawasaki, T., Kawasaki, K.

Microarray of human P450 with an integrated oxygen sensing film for high-throughput detection of metabolic activities, Anal. Chem., 84, 5292−5297

2012年 Chang, G., Mori, Y., Mori, S., Irie, T., Nagai, H., Goto, T., Tatsu, Y., Imaishi, H., Morigaki, K.

Assays of PCB congeners and organochlorine insecticides with the transgenic Arabidopsis and tobacco plants carrying recombinant guinea pig AhR and GUS reporter genes, Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes, 47, 599-607

2012年 Gion, K., Inui, H., Sasaki, H., Utani, Y., Kodama, S., Ohkawa, H.

Enzyme-linked immunosorbent assay with monoclonal and single-chain variable fragment antibodies selective to coplanar polychlorinated biphenyls, Journal of Agricultural and Food Chemistry, 60, 1605-1612

2012年 Inui, H., Takeuchi, T., Uesugi, A., Doi, F., Takai, M., Nishi, K., Miyake, S. and Ohkawa, H.

Photo-regulation of cytochrome P450 activity by using caged compound, Anal. Chem., 84, 155-160

2012年 Morigaki, K., Mizutani, K., Kanemura, E., Tatsu, Y., Yumoto, N., Imaishi, H.

Hydration and temperature dependence of 13C and 1H NMR spectra of the DMPC phospholipid membrane and complete resonance assignment of its crystalline state, J. Phys. Chem. B, 115, 14991-15001

2011年 Nomura, K., Lintuluoto, M., Morigaki, K.

Fusion of lipid vesicles with planar lipid bilayers induced by a combination of peptides, Langmuir, 27, 12515-12520

2011年 Inaba, T., Tatsu, Y., Morigaki, K.
Metabolism of the herbicides chlorotoluron, diuron, linuron, simazine,and atrazine by CYP1A9 and CYP1C1 from Japanese eel (Anguilla japonica) Pesticide Biochemistry and Physiology, 101, 93-102 2011年

Uno,T., Kajia,S., Gotoh,T., Imaishi, H.,
Nakamura,M ., Kanamaru, K.,Yamagata,H., Kaminishi,Y., and Itakura,T.

Assays of dioxins and dioxin-like compounds in actually contaminated soils using transgenic tobacco plants carrying a recombinant mouse aryl hydrocarbon receptor-mediated beta-glucuronidase reporter gene expression system, Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes, 47(1), 59-65

2012年 Inui, H., Gion, K., Utani, Y., Wakai, T., Kodama, S., Eun, H., Kim, Y.-S., and Ohkawa, H.

Sensitive bioimaging in microfluidic channels on the plasmonic substrate: Application of an enhanced fluorescence based on the reverse coupling mode, J. Photochem. Photobiol., A, 221,261-267

2011年 Tawa, K., Cui, X., Kintaka, K., Nishii, J., Morigaki, K.

Structure-selective accumulation of polychlorinated biphenyls in Cucurbita pepo, Journal of Pesticide Science, 36, 363-369

2011年 Matsuo, S, Yamazaki, K., Gion, K., Eun, H., Inui, H.

Vertically integrated human P450 and oxygen sensing film for the assays of P450 metabolic activities, Anal. Chem., 83, 2956-2963

2011年 Chang, G., Morigaki, K., Tatsu, Y., Hikawa, T., Goto, T., Imaishi, H.

Structural basis of species differences between human and experimental animal CYP1A1s in metabolism of 3,3’,4,4,5-pentachlorobiphenyl, Journal of Biochemistry, 149, 487-494

2011年 Yamazaki, K., Suzuki, M., Itoh, T., Yamamoto, K., Kanemitsu, M., Matsumura, C., Nakano, T., Sakaki, T., Fukami, Y., Imaishi, H., Inui, H.

Congener specificity of accumulation of dioxins and dioxin-like compounds in zucchini plants grown hydroponically, Bioscience, Biotechnology, and Biochemistry, 75(4), 705-711

2011年 Inui, H., Wakai, T., Gion, K., Yamazaki, K., Kim, Y.-S., Eun, H.,

「食品の安全性評価へのバイオセンサーの利用」, 2010年 BRAIN TECHNO NEWS, 142, 21-25

2010年 今石浩正, 後藤達志, 宇野知秀, 森垣憲一

Effects of biosurfactants on assays of PCB congeners in transgenic arabidopsis plants carrying a recombinant guinea pig AhR-mediated GUS reporter gene expression system, Journal of
Environmental Science and Health, Part B Pesticides, Food Contaminants, and Agricultural Wastes, 45(8), 773-779

2010年 Shimazu, S., Ohta, M., Inui, H., Nanasato, Y., Ashida, H., and Ohkawa, H.
Phytomonitoring and phytoremediation of agrochemicals and related compounds based on recombinant cytochrome P450s and aryl hydrocarbon receptors (AhRs), Journal of Agricultural and Food Chemistry, 2010,DOI: 10.1021/jf102561d 2010年 Shimazu, S., Inui, H., and Ohkawa, H
Encapsulation of proteins into CaCO3 by phase yransition from vaterite to calcite, Cryst. Growth Des., 10, 4030-4037 2010年 Fujiwara, M., Shiokawa, K., Araki, M., Ashitaka, N., Morigaki, K., Kubota, T., Nakahara, Y.
Recombinant human AhR-mediated GUS reporter gene assays for PCB congeners in transgenic tobacco plants in comparison with recombinant mouse and guinea pig AhRs, Journal of Environmental Science and Health, Part B Pesticides, Food Contaminants, and Agricultural Wastes, 45(8), 764-772 2010年 Shimazu, S., Kawabata, Y., Inayoshi, A., Inui, H., Ashida, H., and Ohkawa, H.
Hormonal regulation and effects of 4 environmental pollutants on vitellogenin gene transcription in the giant water bug, Lethocerus deyrollei (Hemiptera: Belostomatidae), Journal of Insect Conservation, DOI: 10.1007/s10841-010-9315-1 2010年 Nagaba, Y., Tufail, M., Inui, H., and Takeda, M.
The effects of single nucleotide polymorphisms in CYP2A13 on metabolism of 5-methoxypsolaren, Drug Metab. Dispos., 38 , 2110-2116 2010年 Goto, T., Moriuchi, H., Fu, X., Ikegawa, T., Matsubara, T., Chang, G., Uno, T., Morigaki, K., Isshiki, K., Imaishi, H.
Glucose concentration determination based on silica sol-gel encapsulated glucose oxidase optical biosensor arrays, Talanta, 83, 61-65 2010年 Chang, G., Tatsu, Y., Goto, T., Imaishi, H., Morigaki, K.
Molecular recognition on fluidic lipid bilayer microarray corralled by well-defined polymer brushes, Soft Matter, 6 5937-5943 2010年 Nakai, K., Morigaki, K., and Iwasaki, Y.
In-situ imaging of micropatterned phospholipid membranes by surface plasmon fluorescence microscopy, Colloids Surf. B, 81, 447-451 2010年 Tawa, K. and Morigaki, K.
Overexpression of Arabidopsis thaliana LOV KELCH REPEAT PROTEIN 2 promotes tuberization in potato (Solanum tuberosum cv. May Queen), FEBS Letters, 584(11), 2393-2396 2010年 Inui, H., Ogura, Y., and Kiyosue, T.
Phase separation of lipid microdomains controlled by polymerized lipid bilayer matrices, Langmuir, 26, 4126-4129 2010年 Okazaki, T., Tatsu, Y., and Morigaki, K.
Synthesis of optically active strigolactones: enzymatic resolution and asymmetric hydroxylation, Tetrahedron Asymmetry, 21, 1166-1168 2010年 Takikawa, H., Imaishi, H., Tanaka, A., Jikumaru, S., Fujiwara, M., Sasaki, M.
High resolution imaging of patterned model biological membranes by localized surface plasmon microscopy, Appl. Opt., 49, 887-891 2010年 Watanabe, K., R. Miyazaki, G. Terakado, T. Okazaki,Morigaki, K., and H. Kano.
Designed recombinant transcription factor with antibody variable regions, Analytical Chemistry, 81(24), 10162-10166 2009年 Gion, K., Sakurai, Y., Watari, A., and Inui, H.
Ferulic acid production in the brewing of rice wine (sake), Journal of Brewing, 115(2), 116-121 2009年 Uno, T., Itoh, A., Miyamoto, T., Kubo, M., Kanemaru, K., Yamagata, H., Yasufuku, Y., and Imaishi, H.
Polymerized lipid bilayers on solid substrate: Morphologies and obstruction of lateral diffusion, Langmuir, 25, 345-351 2009年 T. Okazaki, T. Inaba, Y. Tatsu, R. Tero, T. Urisu,Morigaki, K.,
Molecular analysis of specificity of anti-nonylphenol polyethoxylate single-chain antibody fragments by grafting and designed point mutations, Molecular Immunology, 46(15), 3125-3130 2009年 Nishi, K., Goda, Yasuhiro, Fujimoto, Shigeru, Inui, H., and Ohkawa, H.
Bioassay of estrogenic compounds in transgenic Arabidopsis plants carrying a recombinant human estrogen receptor gene and a GFP reporter gene, Transgenic Research, 18, 899-909 2009年 Inui, H., Sasaki, H., Chua, N.-H., and Ohkawa, H.
Novel recombinant aryl hydrocarbon receptors for bioassay of aryl hydrocarbon receptor ligands in transgenic tobacco plants, Plant Biotechnology Journal, 7, 119-128 2009年 Kodama, S., Okada, K., Akimoto, K.,Inui, H., and Ohkawa,H.
A scFv antibody-based immunoaffinity chromatography column for clean-up of bisphenol A-contaminated water samples, Journal of Agricultural and Food Chemistry, 57(2), 353-358. 2009年 Inui,H., Takehara, A., Doi, F., Nishi, K., Takai, M., Miyake, S., and Ohkawa, H.
Cloning, expression in yeast, and functional characterization of CYP71D14, a root-specific cytochrome P450 from Petunia hybrida, Acta Physiologia Plantarum, 30, 333-338 2008年 Imaishi, H., and Matushita, T.
Molecular cloning of CYP76A3, a novel cytochrome P450 from Petunia hybrida catalyzing the w-hydroxylation of myristic acid, Biologia Plantarum, 52(2), 242-250. 2008年 Imaishi, H., and Ishitobi, U.
Bioconversion by functional P450 1A9 and P450 1C1 of Anguilla japonica, Comp Biochem Physiol C Toxicol Pharmacol, 147, 278-285. 2008年 Uno T., Okamoto S., Masuda S., Imaishi H., Nakamura M., Kanamaru K., Yamagata H., El-Kady M.A., Kaminishi Y. and Itakura T.
Bioconversion of small molecules by cytochrome P450 species expressed in Escherichia coli, Biotechnology and Applied Biochemistry, 66, 89-97. 2008年 Uno, T., Okamaoto, S., Masuda, S., Itoh, A., Uno, U., Nakamura, M. Kanamaru, K., Yamagata, H. and Imaishi, H.
Micropatterned model biological membranes composed of polymerized and fluid lipid bilayers, Biointerphases, 3, 85-89 2008年 Morigaki, K.,
Interaction of lipopolysaccharide and phospholipid in mixed membranes: Solid-state 31P-NMR spectroscopic and microscopic investigations, Biophys. J, 95, 1226-1238 2008年 Nomura, K., T. Inaba, K. Morigaki, K., Brandenburg, U. Seydel, and S. Kusumoto
Biotin-containing phospholipid vesicle layer formed on the self-assembled monolayer of a saccharide-terminated alkyl disulfide for surface plasmon resonance biosensing, J. Biosci. Bioeng, 105, 527-535 2008年 Ishizuka-Katsura, Y., T. Wazawa, T. Ban, Morigaki, K., and S. Aoyama.
Calcium phosphate composite materials including inorganic powders, BSA or duplex DNA prepared by W/O/W interfacial reaction method, Mater. Sci. Eng., C, 28, 280-288 2008年

Fujiwara, M., K. Shiokawa,Morigaki, K., Y. Tatsu, and Y. Nakahara.

Different uptake for dioxin-like compounds by zucchini subspecies, Chemoshpere, 73, 1602-1607. 2008年 Inui, H., Wakai, T., Gion, K., Kim, Y.-S., and Eun, H.
Expression of Arabidopsis thaliana cytochrome P450 monooxygenase, CYP71A12, in yeast catalyzes the metabolism of herbicide pyrazoxyfen, Plant Biotechnology, 24, 393-396 2007年 Hayashi, E., Fuzimoto, K., and Imaishi, H. (2007)
Determination of Phosphorylated Amino Acid Residues of Rab8 from Bombyx mori Archives of Insect, Biochemistry and Physiology, 66, 89-97 2007年 Uno, T., Nakada, T., Okamoto, Y., Nakamura, M., Matsubara, M., Yamagata, H.,Imaishi, H., Kanamaru, K., and Takagi, M.
Tissue-specific expression of rice CYP72A21 induced by auxins and herbicides,
Plant Biotechnology Reports, 1, 27-36
2007年 Hirose, S., Kawahigashi, H., Tagiri, A., Imaishi, H., Ohkawa, H., and Ohkawa, Y.
Immobilization and activity assay of cytochrome P450 on patterned lipid membranes, Biochem. Biophys. Res. Commun, 355, 926-931 2007年 Ueda, Y., Morigaki, K., Tatsu, Y., Yumoto, N., and Imaishi,H.

Molecular Cloning of CYP76B9, a Cytochrome P450 from Petunia hybrida, Catalyzing the ω-Hydroxylation of Capric Acid and Lauric Acid, Biosci. Biotechnol. Biochem, 71, 104-113

2007年 Imaishi, H., and Petkova, A. M.

Isolation and functional characterization in yeast of CYP72A18, a rice cytochrome P450 that catalyzes (ω-1)-hydroxylation of the herbicide pelargonic acid, Pestic. Biochem. Physiol, 88, 71-77

2007年 Imaishi, H., and Matumoto, S.
Modification of small molecules by using cytochrome P450 expressed in Escherichia coli, J Ind Microbiol Biotechnol, 33,1043-1050 2007年

Uno, T., Nakao, A., Masuda, S., Taniguchi, Y., Kanamaru, K., Yamagata, H., Nakamura, M., Imaishi, H., and Oono, K. (2006)

Visualization and classification of amyloid b supramolecular assemblies, Biochemistry, 46, 15009-15017 2007年 Yagi, H., T. Ban, Morigaki, K., Naiki, H., and Goto, Y.,
Polymerization of diacetylene phospholipid bilayers on solid substrate: Influence of the film deposition temperature, Langmuir, 23, 12254-12260 2007年 Morigaki, K., H. Schnherr, and T, Okazaki.
Direct encapsulation of BSA and DNA into silica microcapsules (hollow spheres), J. Biomed. Mat. Res. A, 81A, 103-112 2007年 Fujiwara, M., Shiokawa,K., Hayashi,K., Morigaki, K. , and Nakahara, Y.,
Vesicles from docosahexaenoic acid, Colloids and Surfaces B, 54, 118-123. 2007年 Namani, T., Ishikawa,T., Morigaki, K., and P. Walde.
Fatty acid vesicles, Curr. Opin. Colloid Interface Sci, 12, 75-80. 2007年 Morigaki, K., and P. Walde.
Aryl hydrocarbon receptor (AhR)-mediated reporter gene expression systems in transgenic tobacco plants, Planta, 227(1), 37-45 2007年 Kodama, S., Okada, K., Inui, H., and Ohkawa, H.
Molecular characterization of specifically active recombinant fused enzymes consisting of CYP3A4 NADPH-cytochrome P450 oxidoreductase and cytochrome b5, Biochemistry, 46(35), 10213-10221 2007年 Inui, H. , Maeda, A., and Ohkawa, H.


発明の名称 番号 年月日 発明者
膜タンパク質を含む人工生体膜 出願番号::


疾患のバイオマーカーの検出方法、検出装置 出願番号::


今石 浩正、伊原航平
炎症性疾患のバイオマーカー 登録番号:


今石 浩正
ナノギャップ構造型基板 登録番号:
森垣 憲一
がん診断用のバイオマーカー 出願番号:
今石 浩正、山本 龍一、福本巧、荒井 啓輔
シトクロムP450酵素代謝活性パターンによる化合物の毒性予測法 登録番号:
今石 浩正、森垣 憲一、堀本 勝久
抗体の可変領域を用いた新規な遺伝子発現調節方法 登録番号:
多様なチトクロムP450分子種の酵素活性を網羅的かつ高効率で測定する方法及びキット 登録番号:
今石 浩正、森垣 憲一、常 鋼、達 吉郎
炎症性疾患のバイオマーカー 出願番号:
今石 浩正
ナノギャップ構造型基板 出願番号:
森垣 憲一
ポリマー脂質二分子膜を用いた機能性基板 登録番号:
森垣 憲一、岡崎 敬、達 吉郎、中島 芳浩
シトクロムP450酵素代謝活性パターンによる化合物の毒性予測法 出願番号:
今石 浩正、森垣 憲一、堀本 勝久
膜結合型P450発現用カセットプラスミド 登録番号:
今石 浩正、宇野 知秀
ヒドロキシ脂肪酸類縁体およびその製造法 出願番号:
今石 浩正、佐々木 満、滝川 浩郷
多様なチトクロムP450分子種の酵素活性を網羅的かつ高効率で測定する方法及びキット 出願番号:
今石 浩正、森垣 憲一、常 鋼、達 吉郎
ポリマー脂質二分子膜を用いた機能性基板 出願番号:
森垣 憲一、岡崎 敬、達 吉郎、中島 芳浩
ヒドロキシ脂肪酸アミドカルボン酸およびその製造法 出願番号:
今石 浩正、佐々木 満、滝川 浩郷
ヒドロキシ脂肪酸エステルおよびその製造法 出願番号:
今石 浩正、佐々木 満、滝川 郷
NADPH依存性酵素又は該依存性酵素により還元される酸化酵素の酵素活性を測定する方法及びキット 出願番号:
森垣 憲一、達 吉郎、今石 浩正
固定化チトクロムP450と酸素センサーを有する積層基板 出願番号:
森垣 憲一、常 鋼、今石 浩正
ベシクル融合法による光重合性脂質二分子膜の作製方法 出願番号:
森垣 憲一, 岡崎 敬
光重合性脂質膜による膜内分子の水平拡散制御 登録番号
森垣 憲一
抗体の可変領域を用いた新規な遺伝子発現調節方法 出願番号:
乾 秀之, 祇園 景子
植物の塊茎形成を制御するための塊茎形成制御ベクター、塊茎形成が制御された植物の製造方法及び植物 出願番号:
清末 知宏、小倉 廉裕、乾 秀之
基板上に固定化された膜結合型チトクローム P450の活性測定 出願番号
今石 浩正、森垣 憲一、達 吉郎、湯元 昇
膜結合型P450発現用カセットプラスミド 出願番号
今石 浩正、宇野 知秀
バイオコンビケムによる化合物ライブラリーの効率的な生産方法 出願番号
今石 浩正、宇野 知秀
内分泌攪乱化学物質モニタリング植物、その生産に使用するDNA、発現ベクター、同植物の生産方法、および、同植物を用いたモニタリング方法 出願番号
乾 秀之、下村 直史、大川 秀郎
コプラナーPCBハプテン、コプラナーPCBに対する抗体およびそれを用いる免疫学的測定方法 出願番号
乾 秀之、武内 哲也、今井 哲弥、大川 秀郎、三宅 司郎
新規チトクロームP450遺伝子 出願番号
大川 秀郎、今石 浩正



積水化学 自然に学ぶものづくり 第75回ウリ科植物に学ぶ土壌浄化法






積水化学 自然に学ぶものづくり 「集積型人工生体膜の創製」

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