研究業績

1) 芳香族・脂肪族アミン類の微生物代謝 / Biodegradation of aromatic and aliphatic amines by microorganism

Takenaka, Shinji; Nomura, Ryosuke; Minegishi, Ayumi; Yoshida, Ken-ichi. Enrichment and characterization of a bacterial culture that can degrade 4-aminopyridine. From BMC Microbiology (2013), 13, 62. (DOI:10.1186/1471-2180-13-62)

Takenaka, Shinji; Koshiya, Jyun; Okugawa, Susumu; Takata, Akiko; Murakami, Shuichiro; Aoki, Kenji. Fe-superoxide dismutase and 2-hydroxy-1,4-benzoquinone reductase preclude the auto-oxidation step in 4-aminophenol metabolism by Burkholderia sp. strain AK-5. Biodegradation (2011), 22(1), 1-11. (DOI:10.1007/s10532-010-9369-5)

Takenaka, Shinji; Sato, Tomomi; Koshiya, Jyun; Murakami, Shuichiro; Aoki, Kenji Gene cloning and characterization of a deaminase from the 4-amino-3-hydroxybenzoate-assimilating Bordetella sp. strain 10d. FEMS Microbiology Letters (2009), 298(1), 93-98. (DOI:10.1111/j.1574-6968.2009.01699.x)

Takenaka, Shinji; Tonoki, Takashi; Taira, Kazuya; Murakami, Shuichiro; Aoki, Kenji Adaptation of Pseudomonas sp. strain 7-6 to quaternary ammonium compounds and their degradation via dual pathways. Applied and Environmental Microbiology (2007), 73(6), 1797-1802. (DOI:10.1128/AEM.02426-06)

Seesuriyachan, Phisit; Takenaka, Shinji; Kuntiya, Ampin; Klayraung, Srikarnjana; Murakami, Shuichiro; Aoki, Kenji. Metabolism of azo dyes by Lactobacillus casei TISTR 1500 and effects of various factors on decolorization. Water Research (2007), 41(5), 985-992. (DOI:10.1016/j.watres.2006.12.001)

Orii, Chika; Takenaka, Shinji; Murakami, Shuichiro; Aoki, Kenji. Metabolism of 4-amino-3-hydroxybenzoic acid by Bordetella sp. strain 10d: a different modified meta-cleavage pathway for 2-aminophenols.Bioscience, Biotechnology, and Biochemistry (2006), 70(11), 2653-2661. (DOI:10.1271/bbb.60264)

Matsumura, Eitaro; Sakai, Masashi; Hayashi, Katsuaki; Murakami, Shuichiro; Takenaka, Shinji; Aoki, Kenji. Constitutive expression of catABC genes in the aniline-assimilating bacterium Rhodococcus species AN-22: Production, purification, characterization and gene analysis of CatA, CatB and CatC. Biochemical Journal (2006), 393(1), 219-226. (DOI:10.1042/BJ20050740)

Takenaka, Shinji; Setyorini, Endang; Kim, Young-Ju; Murakami, Shuichiro; Aoki, Kenji. Constitutive synthesis of enzymes involved in 2-aminophenol metabolism and inducible synthesis of enzymes involved in benzoate, p-hydroxybenzoate, and protocatechuate metabolism in Pseudomonas sp. strain AP-3. Bioscience, Biotechnology, and Biochemistry (2005), 69(5), 1033-1035. (DOI:10.1271/bbb.69.1033)

Matsumura, Eitaro; Ooi, Susumu; Murakami, Shuichiro; Takenaka, Shinji; Aoki, Kenji. Constitutive synthesis, purification, and characterization of catechol 1,2-dioxygenase from the aniline-assimilating bacterium Rhodococcus sp. AN-22. Journal of Bioscience and Bioengineering (2004), 98(2), 71-76. (DOI:10.1016/S1389-1723(04)70245-5)

Orii, Chika; Takenaka, Shinji; Murakami, Shuichiro; Aoki, Kenji. A novel coupled enzyme assay reveals an enzyme responsible for the deamination of a chemically unstable intermediate in the metabolic pathway of 4-amino-3-hydroxybenzoic acid in Bordetella sp. strain 10d. European Journal of Biochemistry (2004), 271(15), 3248-3254. (DOI:10.1111/j.1432-1033.2004.04258.x)

Murakami, Shuichiro; Kohsaka, Chihiro; Okuno, Takao; Takenaka, Shinji; Aoki, Kenji. Purification, characterization, and gene cloning of cis,cis-muconate cycloisomerase from benzamide-assimilating Arthrobacterspecies BA-5-17. FEMS Microbiology Letters (2004), 231(1), 119-124. (DOI:10.1016/S0378-1097(03)00933-9)

Murakami, Shuichiro; Sawami, Yoshimitsu; Takenaka, Shinji; Aoki, Kenji. Cloning of a gene encoding 4-amino-3-hydroxybenzoate 2,3-dioxygenase from Bordetella sp. 10d. Biochemical and Biophysical Research Communications (2004), 314(2), 489-494. (DOI:10.1016/j.bbrc.2003.12.111)

Murakami, Shuichiro; Hayashi, Teruhiko; Maeda, Tetsuya; Takenaka, Shinji; Aoki, Kenji. Cloning and functional analysis of aniline dioxygenase gene cluster, from Frateuria species ANA-18, that metabolizes aniline via an ortho-cleavage pathway of catechol. Bioscience, Biotechnology, and Biochemistry (2003), 67(11), 2351-2358. (DOI:10.1271/bbb.67.2351)

Takenaka, Shinji; Okugawa, Susumu; Kadowaki, Maho; Murakami, Shuichiro; Aoki, Kenji. The metabolic pathway of 4-aminophenol in Burkholderiasp. strain AK-5 differs from that of aniline and aniline with C-4 substituents. Applied and Environmental Microbiology (2003), 69(9), 5410-5413. (DOI:10.1128/AEM.69.9.5410-5413.2003)

Takenaka, Shinji. Production of useful compounds from L-lysine by the microbial enzyme. Kobe Daigaku Nogakubu Gakujutsu Hokoku (2003), 27, 58-62.

Takenaka, Shinji; Asami, Tokiko; Orii, Chika; Murakami, Shuichiro; Aoki, Kenji. A novel meta-cleavage dioxygenase that cleaves a carboxyl-group-substituted 2-aminophenol. Purification and characterization of 4-amino-3-hydroxybenzoate 2,3-dioxygenase from Bordetella sp. strain 10d. European Journal of Biochemistry (2002), 269(23), 5871-5877. (DOI:10.1046/j.1432-1033.2002.03306.x)

Takashima, Atsushi; Murakami, Shuichiro; Takenaka, Shinji; Aoki, Kenji. Regulation by two CatR proteins that differ in binding affinity to catB promoters expressing two cat gene clusters. Bioscience, Biotechnology, and Biochemistry (2001), 65(10), 2146-2153. (DOI:10.1271/bbb.65.2146)

Takenaka, Shinji; Murakami, Shuichiro; Kim, Young-Ju; Aoki, Kenji. Complete nucleotide sequence and functional analysis of the genes for 2-aminophenol metabolism from Pseudomonas sp. AP-3. Archives of Microbiology (2000), 174(4), 265-272. (DOI:10.1007/s002030000203)

Murakami, Shuichiro; Okuno, Takao; Matsumura, Eitaro; Takenaka, Shinji; Shinke, Ryu; Aoki, Kenji. Cloning of a gene encoding hydroxyquinol 1,2-dioxygenase that catalyzes both intradiol and extradiol ring cleavage of catechol. Bioscience, Biotechnology, and Biochemistry (1999), 63(5), 859-865. (DOI:10.1271/bbb.63.859)

Murakami, Shuichiro; Takashima, Atsushi; Takemoto, Junji; Takenaka, Shinji; Shinke, Ryu; Aoki, Kenji. Cloning and sequence analysis of two catechol-degrading gene clusters from the aniline-assimilating bacterium Frateuria species ANA-18. Gene (1999), 226(2), 189-198. (DOI:10.1016/S0378-1119(98)00560-5)

Takenaka, Shinji; Murakami, Shuichiro; Shinke, Ryu; Aoki, Kenji Metabolism of 2-aminophenol by Pseudomonas sp. AP-3: modified meta-cleavage pathway. Archives of Microbiology (1998), 170(2), 132-137. (DOI:10.1007/s002030050624)

Murakami, Shuichiro; Takemoto, Junji; Takenaka, Shinji; Shinke, Ryu; Aoki, Kenji. Purification and characterization of muconate cycloisomerase from aniline-assimilating Rhodococcus erythropolis AN-13. Journal of Fermentation and Bioengineering (1998), 85(5), 521-524. (DOI:10.1016/S0922-338X(98)80074-3)

Murakami, Shuichiro; Nakanishi, Yoko; Kodama, Noriko; Takenaka, Shinji; Shinke, Ryu; Aoki, Kenji. Purification, characterization, and gene analysis of catechol 2,3-dioxygenase from the aniline-assimilating bacterium Pseudomonas species AW-2. Bioscience, Biotechnology, and Biochemistry (1998), 62(4), 747-752. (DOI:10.1271/bbb.62.747)

Kodama, Noriko; Takenaka, Shinji; Murakami, Shuichiro; Shinke, Ryu; Aoki, Kenji. Production of methyl, dimethyl, ethyl, chloro-, fluoro-, and hydroxyl derivatives of catechol from thirteen aromatic amines by the transpositional mutant B-9 of the aniline-assimilating Pseudomonas species AW-2. Journal of Fermentation and Bioengineering (1997), 84(3), 232-235. (DOI:10.1016/S0922-338X(97)82060-0)

Takenaka, Shinji; Murakami, Shuichiro; Shinke, Ryu; Hatakeyama, Kazuhisa; Yukawa, Hideaki; Aoki, Kenji. Novel genes encoding 2-aminophenol 1,6-dioxygenase from Pseudomonasspecies AP-3 growing on 2-aminophenol and catalytic properties of the purified enzyme. Journal of Biological Chemistry (1997), 272(23), 14727-14732. (DOI:10.1074/jbc.272.23.14727)


2) 微生物・酵素変換による有用物質の生産 / Biotransformation of aromatic and aliphatic amines by microorganism

Takenaka, Shinji; Yoshida, Kenji; Tanaka, Kosei; Yoshida, Ken-ichi. Molecular characterization of a novel N-acetyltransferase from Chryseobacterium sp. Applied and Environmental Microbiology (2014), 80(5), 1770-1776. (DOI:10.1128/AEM.03449-13)

Takenaka, Shinji; Honma, Yuuta; Yoshida, Kenji; Yoshida, Ken-ichi
Enantioselective N-acetylation of 2-phenylglycine by an unusual N-acetyltransferase from Chryseobacterium sp. Biotechnology Letters (2013), 35(7), 1053-1059. (DOI:10.1007/s10529-013-1172-z)

Takenaka, Shinji; Cheng, Minyi; Mulyono; Koshiya, Atsushi; Murakami, Shuichiro; Aoki, Kenji. Gene cloning and characterization of arylamine N-acetyltransferase from Bacillus cereus strain 10-L-2. Journal of Bioscience and Bioengineering (2009), 107(1), 27-32. (DOI:10.1016/j.jbiosc.2008.09.012)

Mulyono; Takenaka, Shinji; Sasano, Yasuhiro; Murakami, Shuichiro; Aoki, Kenji. Bacillus cereus strain 10-L-2 produces two arylamine N-acetyltransferases that transform 4-phenylenediamine into 4-aminoacetanilide. Journal of Bioscience and Bioengineering (2007), 103(2), 147-154. (DOI:10.1263/jbb.103.147)

Takenaka, Shinji; Mulyono; Sasano, Yasuhiro; Takahashi, Yuka; Murakami, Shuichiro; Aoki, Kenji. Microbial transformation of aniline derivatives: Regioselective biotransformation and detoxification of 2-phenylenediamine by Bacillus cereus strain PDa-1. Journal of Bioscience and Bioengineering (2006), 102(1), 21-27. (DOI:10.1263/jbb.102.21)

Aoki, Kenji; Takenaka, Shinji. Acetylation of aniline derivative by microbe and enzyme derived from microbe. PCT Int. Appl. (2005), WO 2005090588.

Wang, Chuan Lu; Takenaka, Shinji; Murakami, Shuichiro; Aoki, Kenji. Isolation of a benzoate-utilizing Pseudomonas strain from soil and production of catechol from benzoate by transpositional mutants. Microbiological Research (2001), 156(2), 151-158. (DOI:10.1078/0944-5013-00096)

Wang, Chuan Lu; Takenaka, Shinji; Murakami, Shuichiro; Aoki, Kenji. Production of catechol from benzoate by the wild strain Ralstonia species Ba-0323 and characterization of its catechol 1,2-dioxygenase. Bioscience, Biotechnology, and Biochemistry (2001), 65(9), 1957-1964. (DOI:10.1271/bbb.65.1957)


3) 特異な微生物酵素の検索と特性解析 / Characterization of hydrolytic enzymes

Pinpanit Boonchuay; Shinji Takenaka; Ampin Kuntiya; Charin Techapun; Noppol Leksawasdi; Phisit Seesuriyachan; and Thanongsak Chaiyaso. Purification, characterization, and molecular cloning of the xylanase from Streptomyces thermovulgaris TISTR1948 and its application to xylooligosaccharide production. Journal of Molecular Catalysis B: Enzymatic (2016) accepted ('16/3/15) Chiang Mai大との国際共著


Shinji Takenaka; Mayo Umeda; Hisanori Senba; Dai Koyama; Kosei Tanaka;
Ken-ichi Yoshida and Mikiharu Doi. Heterologous expression and characterization
of the Aspergillus aspartic protease involved in the hydrolysis and decolorization
of red-pigmented proteins. Journal of the Science of Food and Agriculture,
2016. (DOI: 10.1002/jsfa.7688)


Takenaka Shinji; Miyatake Ayaka; Tanaka Kosei; Kuntiya Ampin, Techapun Charin, Leksawasdi Noppl, Seesuriyachan Phisit, Chaiyaso Thaiyaso, Watanabe M, Yoshida Ken-Ichi.Characterization of the native form and the carboxy-terminally truncated halotolerant form of α-amylases from Bacillus subtilis strain FP-133. Journal of Basic Microbiology (2015), 55(6), 780-789. (DOI:10.1002/jobm.201400813. Epub 2015 Feb 16.) Chiang Mai大との国際共著


Tsuji Shogo, Tanaka Kosei, Takenaka Shinji, Yoshida Ken-Ichi. .Enhanced secretion of natto phytase by Bacillus subtilis. Bioscience, Biotechnology, and Biochemistry (2015), 79(11), 1906-1914.


Bien, Thi Lan Thanh; Tsuji, Shogo; Tanaka, Kosei; Takenaka, Shinji; Yoshida, Ken-ichi. Secretion of heterologous thermostable cellulases in Bacillus subtilis. Journal of General and Applied Microbiology (2014), 60(5), 175-182. (DOI:10.2323/jgam.60.175)

Aoki, Kenji; Matsubara, Sayaka; Umeda, Mayo; Tachibanac, Shusaku; Doi, Mikiharu; Takenaka, Shinji. Aspartic protease from Aspergillus (Eurotium) repensstrain MK82 is involved in the hydrolysis and decolourisation of dried bonito (Katsuobushi). Journal of the Science of Food and Agriculture (2013), 93(6), 1349-1355. (DOI:10.1002/jsfa.5896)

Takenaka, Shinji; Hano, Shinpei; Cheng, Minyi; Yoshida, Ken-ichi; Aoki, Kenji. Organic solvent-tolerant elastase efficiently hydrolyzes insoluble, crosslinked, protein fiber of eggshell membranes. Biotechnology Letters (2012), 34(5), 949-955. (DOI:10.1007/s10529-012-0861-3)

Takenaka, Shinji; Yoshida, Nobutaka; Yoshida, Ken-ichi; Murakami, Shuichiro; Aoki, Kenji. Molecular cloning and sequence analysis of two distinct halotolerant extracellular proteases from Bacillus subtilis FP-133. Bioscience, Biotechnology, and Biochemistry (2011), 75(1), 148-151. (DOI:10.1271/bbb.100588)

Aoki, Kenji; Takenaka, Shinji; Doi, Kanji. Aspergillus repens protease for bleaching of color stains with hemoglobins and myoglobin. Jpn. Kokai Tokkyo Koho (2009), JP 2009219483.

Cheng, Minyi; Takenaka, Shinji; Aoki, Shunsuke; Murakami, Shuichiro; Aoki, Kenji. Purification and characterization of an eggshell membrane decomposing protease from Pseudomonas aeruginosa strain ME-4. Journal of Bioscience and Bioengineering (2009), 107(4), 373-378. (DOI:10.1016/j.jbiosc.2008.12.010)

Kaneko, Shuji; Cheng, Minyi; Murai, Hiroshi; Takenaka, Shinji; Murakami, Shuichiro; Aoki, Kenji. Purification and characterization of an extracellular laccase from Phlebia radiata strain BP-11-2 that decolorizes fungal melanin. Bioscience, Biotechnology, and Biochemistry (2009), 73(4), 939-942. (DOI:10.1271/bbb.80740)

Yuan, Qingzhu; Adachi, Tsuyoshi; Takenaka, Shinji; Murakami, Shuichiro; Tanaka, Machiko; Aoki, Kenji. Production and accumulation of xylooligosaccharides with long chains by growing culture and xylanase of a mutant strain of Bacillus pumilus X-6-19. Shengwu Gongcheng Xuebao (2008), 24(7), 1221-1227.

Nagasaki, Kenji; Kumazawa, Masaro; Murakami, Shuichiro; Takenaka, Shinji; Koike, Kenzo; Aoki, Kenji. Purification, characterization, and gene cloning of Ceriporiopsis sp. strain MD-1 peroxidases that decolorize human hair melanin. Applied and Environmental Microbiology (2008), 74(16), 5106-5112. (DOI:10.1128/AEM.00253-08)

Murakami, Shuichiro; Nagasaki, Kenji; Nishimoto, Haruka; Shigematu, Ryo; Umesaki, Jun; Takenaka, Shinji; Kaulpiboon, Jarunee; Prousoontorn, Manchumas; Limpaseni, Tipaporn; Pongsawasdi, Piamsook; et al. Purification and characterization of five alkaline, thermotolerant, and maltotetraose-producing α-amylases from Bacillus halodurans MS-2-5, and production of recombinant enzymes in Escherichia coli. Enzyme and Microbial Technology (2008), 43(4-5), 321-328. (DOI:10.1016/j.enzmictec.2008.05.006)

Murakami, Shuichiro; Nishimoto, Haruka; Toyama, Yosuke; Shimamoto, Etsuko; Takenaka, Shinji; Kaulpiboon, Jarunee; Prousoontorn, Manchumas; Limpaseni, Tipaporn; Pongsawasdi, Piamsook; Aoki, Kenji. Purification and characterization of two alkaline, thermotolerant α-amylases from Bacillus halodurans 38C-2-1 and expression of the cloned gene in Escherichia coli. Bioscience, Biotechnology, and Biochemistry (2007), 71(10), 2393-2401. (DOI:10.1271/bbb.60666)

Setyorini, Endang; Kim, Young-ju; Takenaka, Shinji; Murakami, Shuichiro; Aoki, Kenji. Purification and characterization of a halotolerant intracellular protease from Bacillussubtilisstrain FP-133. Journal of Basic Microbiology (2006), 46(4), 294-304. (DOI:10.1002/jobm.200510086)

Setyorini, Endang; Takenaka, Shinji; Murakami, Shuichiro; Aoki, Kenji. Purification and characterization of two novel halotolerant extracellular proteases from Bacillus subtilis strain FP-133. Bioscience, Biotechnology, and Biochemistry (2006), 70(2), 433-440. (DOI:10.1271/bbb.70.433)

その他

Tomohide Uno,Chiho Izumi,Shinji Takenaka, et al., Functional characterization of CYP1A9 and CYP1C1 from Anguillus japonica . (2015), 40(2), 360-368.

Zhou, Qi; Takenaka, Shinji; Murakami, Shuichiro; Seesuriyachan, Phisit; Kuntiya, Ampin; Aoki, Kenji. Screening and characterization of bacteria that can utilize ammonium and nitrate ions simultaneously under controlled cultural conditions. Journal of Bioscience and Bioengineering (2007), 103(2), 185-191. (DOI:10.1263/jbb.103.185)

Takenaka, Shinji; Zhou, Qi; Kuntiya, Ampin; Seesuriyachan, Phisit; Murakami, Shuichiro; Aoki, Kenji. Isolation and characterization of thermotolerant bacterium utilizing ammonium and nitrate ions under aerobic conditions. Biotechnology Letters (2007), 29(3), 385-390. (DOI:10.1007/s10529-006-9255-8)

Aoki, Kenji; Takenaka, Shinji; Murakami, Shuichiro Method for simultaneous nitrification and denitrification for removing ammonium and nitrate by microorganism. Jpn. Kokai Tokkyo Koho (2005), JP 2005034783.

Kim, Young-Ju; Yoshizawa, Makoto; Takenaka, Shinji; Murakami, Shuichiro; Aoki, Kenji. Ammonia assimilation in Klebsiella pneumoniae F-5-2 that can utilize ammonium and nitrate ions simultaneously: purification and characterization of glutamate dehydrogenase and glutamine synthetase. Journal of Bioscience and Bioengineering (2002), 93(6), 584-588. (DOI:10.1016/S1389-1723(02)80241-9)

Kim, Young-Ju; Yoshizawa, Makoto; Takenaka, Shinji; Murakami, Shuichiro; Aoki, Kenji. Isolation and culture conditions of a Klebsiella pneumoniae strain that can utilize ammonium and nitrate ions simultaneously with controlled iron and molybdate ion concentrations. Bioscience, Biotechnology, and Biochemistry (2002), 66(5), 996-1001. (DOI:10.1271/bbb.66.996)

Takenaka, Shinji. Production of useful compounds from L-lysine by the microbial enzyme. Kobe Daigaku Nogakubu Gakujutsu Hokoku (2003), 27, 58-62.