Ueyama T: Rho-family small GTPases: from highly polarized sensory neurons to cancer cells. Cells, 8(2), 92, 2019. doi: 10.3390/cells8020092
Leto TL, Morand S, Hurt D, Ueyama T: Targeting and regulation of reactive oxygen species generation by NOX family NADPH oxidases. Antioxid. Redox Signal. 11, 2607-2619, 2009. Featured with cover photo. doi: 10.1089/ars.2009.2637.
2024
Kaizuka T, Suzuki T, Kishi N, Tamada K, Kilimann MW, Ueyama T, Watanabe M, Okano H, Dohmae N, Shimogori T, Takumi T: Remodeling of the postsynaptic proteome in male mice and marmosets during synapse development.Nat. Commun. 15(1): 2496, 2024. doi: 10.1038/s41467-024-46529-9.
2023
Niki Y, Adachi N, Fukata M, Fukata Y, OkuS, Makino-Okamura C, Takeuchi T, Wakamatsu K, Ito S, Declercq L, Yarosh DB, Mammone T, Nishigori C, Saito N, Ueyama T: S-palmitoylation of tyrosinase at cysteine500 regulates melanogenesis. J. Invest. Dermatol. 143, 317-327, 2023. doi: 10.1016/j.jid.2022.08.040.
Nakamura T, Sakaguchi H, Mohri H, Ninoyu Y, Goto A, Yamaguchi T, Hishikawa Y, Matsuda M, Saito N, Ueyama T: Dispensable role of Rac1 and Rac3 after cochlear hair cell specification. J. Mol. Med. 101, 843-854, 2023. Featured with cover photo. doi: 10.1007/s00109-023-02317-4.
Kurasawa S, Mohri H, Tabuchi K, Ueyama T: Loss of synaptic ribbons are an early cause in ROS-induced acquired sensorineural hearing loss.Neurobiol. Dis. 186, 106280, 2023. doi: 10.1016/j.nbd.2023.106280.
2022
Kim BJ, Miyoshi T, Chaudhry T, Friedman TB, Choi BY, Ueyama T: Late-onset hearing loss case associated with a heterozygous truncating variant of DIAPH1. Clin. Genet. 101, 466-471, 2022. doi: 10.1111/cge.14115.
HirakawaK, Taguchi K, Murakawa S, Asano M, Noguchi S, Kikkawa S, Harada K, Adachi N, Ueyama T, Hide I, Tanaka S, Sakai N: Effects of flurbiprofen on the functional regulation of serotonin transporter and its misfolded mutant. J. Pharmacol. Sci. 148, 187-195, 2022.
2021
Mohri H, Ninoyu Y, Sakaguchi H, Hirano S, Saito N, Ueyama T: Nox3-derived superoxide in cochleae induces sensorineural hearing loss. J. Neurosci. 41, 4716-4731, 2021. doi: 10.1523/JNEUROSCI.2672-20.2021.
2020
Ninoyu Y, Sakaguchi H, Chen L, Suzuki T, Hirano S, Hisa Y, Saito N, Ueyama T: The integrity of cochlear hair cells is established and maintained through the localization of Dia1 at apical junctional complexes and stereocilia. Cell Death Dis. 11(7): 536, 2020. doi: 10.1038/s41419-020-02743-z.
Morioka S, Sakaguchi H, Mohri H, Taniguchi-Ikeda M, Kanagawa M, Suzuki T, Miyagoe-Suzuki Y, Toda T, Saito N, Ueyama T: Congenital hearing impairment associated with peripheral cochlear nerve dysmyelination in glycosylation-deficient muscular dystrophy. PLOS Genet. 16(5): e1008826, 2020. doi: 10.1371/journal.pgen.1008826.
Ueyama T, Sakuma M, Nakatsuji M, Uebi T, Hamada T, Aiba A, Saito N: Rac-dependent signaling from keratinocytes promotes differentiation of intradermal white adipocytes. J. Invest. Dermatol. 140, 75-84, 2020. doi: 10.1016/j.jid.2019.06.140.
2019
Kim BJ, Ueyama T, Miyoshi T, Lee S, Han JH, Park HR, Kim AR, Oh J, Kim MY, Kang YS, Oh DY, Yun J, Hwang SM, Kim NKD, Park WY, Kitajiri SI, Choi BY: Differential disruption of autoinhibition and defect in assembly of cytoskeleton during cell division decide the fates of human DIAPH1-related cytoskeletopathy. J. Med. Genet. 56, 818-827, 2019.
Shirafuji T, Shimazaki H, Miyagi T, Ueyama T, Adachi N, Tanaka T, Hide I, Saito S, Sakai S: Spinocerebellar ataxia type 14 caused by a nonsense mutation in the PRKCG gene. Mol. Cell. Neurosci. 98, 46-53, 2019.
2018
Morioka S, Sakaguchi H, Yamaguchi T, Ninoyu Y, Mohri H, Nakamura T, Hisa Y, Ogita K, Saito N, Ueyama T. Hearing vulnerability after noise exposure in a mouse model of reactive oxygen species overproduction. J. Neurochem. 146, 459-473, 2018. doi: 10.1111/jnc.14451.
Shirafuji T, Ueyama T, Adachi N, Yoshino YK-I, Sotomaru Y, Uwada J, Kaneoka A, Ueda T, Tanaka S, Hide I, Saito N, Sakai N. The role of cysteine string protein alpha (CSPα) phosphorylation at Serine 10, and 34, by protein kinase Cγ for presynaptic maintenance. J. Neurosci. 38, 278-290, 2018. doi: 10.1523/JNEUROSCI.1649-17.2017.
Sakamoto I, Ueyama T, Hayashibe M, Nakamura T, Mohri H, Kiyonari H, Shigyo M, Tohda C, Saito N: Roles of Cdc42 and Rac in Bergmann glia during cerebellar corticogenesis. Exp. Neurol. 302, 57-67, 2018.
Nakazono A, Adachi N, Takahashi H, Seki T, Hamada D, Ueyama T, Sakai N, and Saito N. Pharmacological induction of heat shock proteins ameliorates toxicity of mutant PKCγ in spinocerebellar ataxia type 14. J. Biol. Chem. 293, 14758-14774, 2018.
Miyahara T, Adachi N, Seki T, Hide I, Tanaka S, Saito N, Irifune I, Sakai N. Propofol induced diverse and subtype-specific translocation of PKC families. J. Pharmacol. Sci. 2018.
2017
Nakamura T, Ueyama T, Ninoyu Y, Sakaguchi H, Choijookhuu N, Hishikawa Y, Kiyonari H, Kohta M, Sakahara M, de Curtis I, Kohmura E, Hisa Y, Aiba A, and Saito N. Novel role of Rac-Mid1 signaling in medial cerebellar development. Development, 144, 1863-1875, 2017. doi: 10.1242/dev.147900.
Ishii T, Ueyama T, Shigyo M, Kohta M, Kondoh T, Kuboyama T, Uebi T, Hamada T, Gutmann D.H, Aiba A, Kohmura E, Tohda C, Saito N. A novel Rac1-GSPT1 signaling pathway controls astrogliosis following central nervous system injury. J. Biol. Chem. 292, 1240-1250, 2017. doi: 10.1074/jbc.M116.748871.
Hanes CM, D’Amico AE, Ueyama T, Wong AC, Zhang X, Hynes WF, Barroso MM, Cady NC, Trebak M, Saito N, Lennartz MR. Golgi-associated PKC-ε is delivered to phagocytic cups: Role of PI4P. J. Immunol. 199, 271-277, 2017.
Shirafuji T, Ueyama T, Tanaka S, Hide I, Saito N, Sakai N. Validation of anti CSPa, SNAP25, Tyrosine hydroxylase, Ubiquitin, cleaved caspase 3, and pSer PKC motif antibodies for utilization in western blotting. Acta Histochem. Cytochem. 50, 177-180, 2017.
Hayashi D, Yagi K, Song C, Ueda S, Yamanoue M, Topham M, Suzaki T, Saito N, Emoto N, Shirai Y. Diacylglycerol kinase α is involved in the vitamin E-induced amelioration of diabetic nephropathy in mice. Sci. Rep. 7, 2597, 2017.
Hanaki Y, Kikumori M, Tokuda H, Okamura M, Dan S, Adachi N, Saito N, Yanagita R, Irie K. Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities. Molecules. 22, 2017.
Kakumu E, Nakanishi S, Shiratori H.M, Kato A, Kobayashi W, Machida S, Yasuda T, Adachi N, Saito N, Ikura T, Kurumizaka H, Kimura H, Yokoi M, Sakai W. and Sugasawa K. Xeroderma pigmentosum group C protein interacts with histones: Regulation by acetylated states of histone H3. Genes to Cells. 22, 310-327, 2017.
Kakehi T, Yagi K, Saito N, Shirai Y. Effects of vitamin E and its derivatives on diabetic nephropathy in Rats and identification of diacylglycerol kinase subtype involved in the improvement of diabetic nephropathy. Functional Foods in Health and Disease. 7, 816-832, 2017.
2016
Ueyama T, Ninoyu Y, Nishio S, Miyoshi Y, Torii H, Nishimura K, Sugahara K, Sakata H, Thumkeo D, Sakaguchi H, Omori, Watanabe N, Usami S, Saito N, Kitajiri S. Constitutive activation of DIA1 (DIAPH1) via C-terminal truncation causes human sensorineural hearing loss. EMBO Mol. Med. 8(11), 1310-1324, 2016. doi: 10.15252/emmm.201606609.
2015
Ueyama T, Sakuma M, Ninoyu Y, Hamada T, Dupuy C, Geiszt M, Leto TL, Saito N. The extracellular A-loop of dual oxidases affects the specificity of reactive oxygen species release. J. Biol. Chem. 290, 6495-506, 2015.
Takahashi H, Adachi N, Shirafuji T, Danno S, Ueyama T, Vendruscolo M, Shuvaev AN, Sugimoto T, Seki T, Hamada D, Irie K, Hirai H, Sakai N, Saito N. Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein. Hum. Mol. Genet. 2015, 24, 525-39.
Maeda J, Inoue K, Ichimura R, Takahashi M, Kodama Y, Saito N, Yoshida M. Essential role of constitutive androstane receptor in Ginkgo biloba extract induced liver hypertrophy and hepatocarcinogenesis. Food Chem Toxicol. 2015, 24, 83:201-209, 2015.
2014
Ueyama T, Sakaguchi H, Nakamura T, Goto A, Morioka S, Shimizu A, Nakao K, Hishikawa Y, Ninoyu Y, Kassai H, Suetsug J, Koji T, Fritzsch B, Yonemura S, Hisa Y, Matsuda M, Aiba A, and Saito N. Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells. J. Cell Sci. 127, 2040-2052, 2014. doi:10.1242/jcs.143602.
Shirafuji T, Ueyama T, Yoshino K-I, Takahashi H, Adachi N, Ago Y, Koda K, Nashida T, Hiramatsu N, Matsuda T, Toda T, Sakai N, and Saito N. The role of Pak-Interacting Exchange Factor-β phosphorylation at Serines 340 and 583 by PKCγ in dopamine release. J. Neurosci. 34, 9268-9280, 2014. doi: 10.1523/JNEUROSCI.4278-13.2014.
Sakuma M, Shirai Y, Ueyama T, and Saito N. Diacylglycerol kinase gamma regulates antigen-induced mast cell degranulation by mediating Ca2+ influxes. Biochem. Biophys. Res. Commun. 445, 340-5, 2014.
Choi H, Park J, Kim H, Noh M, Ueyama T, Bae Y, Lee TR, Shin DW. Hydrogen peroxide generated by DUOX1 regulates the expression levels of specific differentiation markers in normal human keratinocyte. J. Dermatol. Sci. 74, 56-63 2014.
Maillard L, Saito N, Hlawaty H, Friand V, Suffee N, Chmilewsky F, Haddad O, Laguillier C, Guyot E, Ueyama T, Oudar O, Sutton A, Charnaux N. RANTES/CCL5 mediated-biological effects depend on the syndecan-4/PKCα signaling pathway. Biology Open, 3, 995-1004. 2014.
Yamamoto K, Seki T, Yamamoto H, Adachi N, Tanaka S, Hide I, Saito N, and Sakai N. Deregulation of the actin cytoskeleton and macropinocytosis in response to phorbol ester by the mutant protein kinase Cγ that causes spinocerebellar ataxia type 14. Frontiers in Physiology, 5, 216(1-10), 2014.
Shirai Y, and Saito N. Diacylglycerol kinase as a possible therapeutic target for neuronal diseases. J. Biomedical Science. 21, 28-28, 2014.
Kano T, Kouzuki T, Mizuno S, Ueda S, Yamanoue M, Sakane F, Saito N and Shirai Y. Both the C1 domain and a basic amino acid cluster at C-terminus are important for neurite and branch induction ability of DGKβ. Biochem. Biophys. Res. Commun. 447, 89-94, 2014.
Makino-Okamura C, Niki Y, Takeuchi S, Nishigori C, Declercq L, Yaroch D.B, and Saito, N. Heparin inhibits melanosome uptake and inflammatory response coupled with phagocytosis through blocking PI3k/Akt and MEK/ERK signaling pathways in human epidermal keratinocytes. Pigment Cell & Melanoma Research, 1063-74, 2014.
Maeda J, Kijima A, Inoue K, Ishii Y, Ichimura R, Takasu S, Kuroda K, Matsushita K, Kodama Y, Saito N, Umemura T, and Yoshida M. In Vivo Genotoxicity Assessment of Ginkgo biloba Extract Using the Comet, Micronucleus, and Gene Mutation Assay. Toxicological Sciences, 140, 298-306, 2014.
2013
Ueyama T, SonJ, Kobayashi T, HamadaT, Nakamura T, Sakaguchi H, Shirafuji T, Saito N: Negative charge in the N-termini of RhoGDIs regulate targeting of the RhoGDI-Rac1 complex to membrane.J Immunol. 191, 2560-2569, 2013.
Yamashita K, Miyoshi T, Arai Y, Mizugishi K, Takaori-Kondo A, Ueyama T. Enhanced generation of reactive oxygen species by interferon-γ may have contributed to successful treatment of invasive pulmonary aspergillosis in a patient with chronic granulomatous disease. Int. J. Hematol. 505-10, 97, 2013.
Schlam D, Bohdanowicz M, Schlam D, Steinberg BE, Ueyama T, Du G, Grinstein S, Fairn GD: Diacylglycerol kinases terminate diacylglycerol signalling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation. J. Biol. Chem. 288, 23090-23104, 2013.
Bohdanowicz M, Schlam D, Hermansson M, Rizzuti D, Fairn GD, Ueyama T, Somerharju P, Du G, Grinstein S: Phosphatidic acid is required for the constitutive ruffling and macropinocytosis of phagocytes. Mol. Biol. Cell, 24, 1700-1712, 2013.
Suzuki M, Iio Y, Saito N, and Fujimoto T. Protein kinase Cη is targeted to lipid droplets. Histchem. Cell Biol. 139, 505-11, 2013.
Nishimoto T, Kashiwagi K, Saito N, and Shirai Y. Both C1B domain and pseudosubstrate region are necessary for saturated fatty acidmembrane; distinct role of intramolecular domains for different translocation. Biochem. Biophys. Res. Commun. 432, 384–388, 2013.
Wood TR, Chow RY, Hanes CM, Zhang X, Kashiwagi K, Shirai Y, Trebak M, Loegering DJ, Saito N, and Lennartz MR. PKC-ε pseudosubstrate and catalytic activity are necessary for membrane delivery during IgG-mediated phagocytosis. J. Leukoc. Biol. 94, 109-122, 2013.
Ogawa K, Seki T, Onji T, Adachi N, Tanaka S, Hide I, Saito N and Sakai N. Mutant γPKC that causes spinocerebellar ataxia type 14 upregulates Hsp70, which protects cells from the mutant’s cytotoxicity. Biochem. Biophys. Res. Commun. 440, 25-30, 2013.
Ishisaka M, Tsuruma K, Shimazawa M, Shirai Y, Saito N, and Hara H. Increased seizure susceptibility in a mouse with diacylglycerol kinase β2 deficiency. Neuroscience & Medicine. 4, 117-122, 2013.
2012
Sakuma M, Shirai Y, Yoshino K-I, Kuramasu M, Nakamura T, Yanagita T, Mizuno K, Hide I, Nakata Y, Saito N. Novel PKCa-mediated phosphorylation site(s) on cofilin and their potential role in terminating histamine release. Mol. Biol. Cell. 23, 3707-3721, 2012.
Seki T, Ken-ich Yoshino K, Tanaka S, Dohi E, Onji T, Yamamoto K, Hide I, Paulson H.L, Saito N, Sakai N. Establishment of a Novel Fluorescence-Based Method to Evaluate Chaperone-Mediated Autophagy in a Single Neuron. PLoS ONE, 7(2): e31232, 2012.
Matsubara T, Ikeda M, Kiso Y, Sakuma M, Yoshino K-I, Sakane F, Merida I, Saito N, and Shirai Y. c-Abl tyrosine kinase regulates serum-induced nuclear export of diacylglycerol kinase α by phosphorylation at Tyr218. J. Biol. Chem. 287, 5507-5517, 2012.
2011
Ueyama T, Nakakita J, Kobayashi T, Kobayashi T, Son J, Sakaguchi H, Leto T, and Saito N. Cooperation of p40phox with p47phox for Nox2 activation during FcγR-mediated phagocytosis -Mechanism for acquisition of p40phox PI(3)P binding- J. Biol. Chem. 286, 40693–40705, 2011. doi: 10.1074/jbc.M111.237289.
Sakai N, Saito N, and Seki T. Molecular pathophysiology of neurodegenerative disease caused by γPKC mutations. World J. Biological Psychiatry, 12(S1), 95-98, 2011.
Seki T, Adachi N, Abe-Seki N, Shimahara T, Takahashi H, Yamamoto K, Saito N, and Sakai N. Elucidation of the Molecular Mechanism and Exploration of Novel Therapeutics for Spinocerebellar Ataxia Caused by Mutant Protein Kinase Cγ. J. Pharmacol. Sci. 116, 239-247, 2011.
Shibata Y, Kawada-Matsuo M, Shirai Y, Saito N, Li D, and Yamashita Y. Streptococcus mutans diacylglycerol kinase homologue: a potential target for anti-caries chemotherapy. J. Med. Microbiol. 60, 625-630, 2011.
Shirai Y, Morioka S, Sakuma M, Yoshino K, Otsuji C, Sakai N, Kashiwagi K, Chida K, Shirakawa R, Horiuchi H, Nishigori C, Ueyama T, Saito N. Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocytes differentiation. Mol. Biol. Cell, 22, 1340-1352, 2011.
Matsuo A, Bellier JP, Nishimura M, Yasuhara O, Saito N, and Kimura H. Nuclear Choline Acetyltransferase Activates Transcription of a High-affinity Choline Transporter. J. Biol. Chem. 286, 5836-5845. 2011.
2010
Kawasaki T, Ueyama T, Lange I, Feske S, Saito N. PKC-induced phosphorylation of Orai1 regulates intracellular Ca2+ level via store operated Ca2+ channel. J. Biol. Chem. 285, 25720-30, 2010.
Yanase Y, Hide I, Mihara S, Shirai Y, Saito N, Nakata Y, Hide M, and Sakai N. A critical role of conventional protein kinase C in morphological changes of rodent mast cells. Immunol. Cell. Biol. 89, 149-59, 2010.
Mukai R, Shirai Y, Saito N, Fukuda I, Nishiumi S, Yoshida K, Ashida H. Supression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction. Arch. Biochem. Biophys. 501, 134-141, 2010.
Seki T, Abe-Seki N, Kikawada T, Takahashi H, Yamamoto K, Adachi N, Tanaka S, Hide I, Saito N, and Sakai N. The effect of trehalose on the properties of mutant γPKC, which causes spinocerebellar ataxia type 14 (SCA14), in neuronal cell lines and cultured Purkinje cells. J. Biol. Chem. 285, 33252-33264, 2010.
Kakefuda K, Oyagi A, Ishisaka M, Tsuruma K, Shimazawa M, Yokota K, Shirai Y, Horie K, Saito N, Takeda J, and Hara H. Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. PLoS One, 5(10): e13447, 2010.
Shirai Y, Kozuki T, Kakefuda K, Moriguchi S, Oyagi A, Horie K, Shimazawa M, Fukunaga K, Takeda J, Saito N, Hara H. Essential role of diacylglycerol kinase beta (DGKβ) in neurite spine formation, contributing to cognitive function including spatial and long-term memory. PLoS One. 5(7):e11602, 2010.
Yamamoto K, Seki T, Adachi N, Takahashi T, Tanaka S, Hide I, Saito N, Sakai N. Mutant protein kinase Cγ that causes spinocerebellar ataxia type 14 (SCA14) is selectively degraded by autophagy. Genes to Cells, 15, 425-38, 2010.
Kodama N, Mizuno S, Nanba H, and Saito N. Potential Antitumor Activity of a Low Molecular Weight Protein Fraction (MLP-Fraction) from Grifola frondosa through Enhancement of Cytokine Production. Journal of Medicinal Food. 13, 20-30, 2010.
Toyohira Y, Ueno S, Tsutsui M, Itho H, Sakai N, Saito N, Takahashi K, and Yanagihara N. Stimulatory effects of the soy phytoestrogen genistein on noradrenalin transporter and serotonin transporter activity. Mol. Nutr. Food Res. 54, 516-524, 2010.
2009
Morand S, Ueyama T, Tsujibe S, Saito N, Korzeniowska A, and Leto TL. Duox maturation factors form cell surface complexes with Duox affecting the specificity of reactive oxygen species generation. FASEB J. 23, 1205-1218, 2009.
Mukai R, Shirai Y, Saito N, Yoshida K-I, and Ashida H. Subcellular localization of flavonol aglycone inhepatocytes visualized by confocal laser scanning fluorescent microscope. Cytotechnology, 59, 177-182, 2009.
Adachi E, Kazoe Y, Sato Y, Suzuki Y, Urano T, Ueyama T, Saito N, Nikolaev VO, Lohse MJ, Tominaga M, and Mogami H. A technique for monitoring multiple signals with a combination of prism-based total internal reflection fluorescence microscopy and epifluorescence microscopy. Pflugers Arch. 459, 227-234, 2009.
Nakagawa Y, Yanagita RC, Hamada N, Murakami A, Takahashi H, Saito N, Nagai H, and Irie K. A simple analog of tumor-promoting aplysiatoxin is an antineoplastic agent rather than a tumor promoter: development of a synthetically accessible PKC activator with bryostatin-like activity. J. Am. Chem. Soc. 131, 7573-7579, 2009.
Shibata Y, Jan R. van der Ploeg, Kozuki, T., Shirai, Y., Saito, N., Kawada,M., Takeshita, T., and Yamashita, Y. Kinase activity of the dgk gene product is involved 1 in the virulence of Streptococcus tans. Microbiology, 155, 557-565, 2009.
Seki T, Shimahara T, Yamamoto K, Abe N, Amano T, Adachi N, Takahashi H, Kashiwagi K, Saito N, and Sakai N. Mutant γPKC found in spinocerebellar ataxia type 14 induces aggregate-independent maldevelopment of dendrites in primary cultured Purkinje cells. Neurobiology of Disease, 33, 260-273, 2009.
Takaoka K, Shirai Y, and Saito N. Inflammatory Cytokine TNF-α enhances NGF Production in Human Keratinocytes, HaCaT Cells. J. Pharmacol. Sci. 111, 381-391, 2009.
2008
Ueyama T, Kusakabe T, Karasawa S, Kawasaki T, Shimizu A, Son J-H, Shirai Y, Leto TL, Miyawaki A, and Saito N. Sequential targeting of p67phox to phagosomes by regulated conformational changes of adaptors evaluated by the novel monometric Kusabira Green system. J. Immunol. 181:629-40, 2008.
Ashida N, Ueyama T, Rikitake K, Shirai Y, Eto M, Kondoh T, Kohmura E, and Saito N. Ca2+ oscillation induced by P2Y2 receptor activation and its regulation by a neuron-specific subtype of PKC (γPKC). Neurosceince Letters 446, 123-128, 2008.
Kawasaki T, Kobayashi T, Ueyama T, Shirai Y, and Saito N. Regulation of Clathrin Dependent Endocytosis by Diacylglycerol kinased -Importance of Kinase Activity and Binding to AP2α. Biochem. J. 409:471-479, 2008.
Ibi M, Matsuno K, Shiba D, Katsuyama M, Iwata K, Kakehi T, Nakagawa T, Sango K, Shirai Y, Yokoyama T, Kaneko S, Saito N, and Yabe-Nishimura C. A newly identified role for NOX1/NADPH oxidase in inflammatory pain. J. Neurosci. 28, 9486-9494, 2008.
Shirai Y, Adachi N, and Saito N. Minireview : Protein kinase Cε-function in neurons. FEBS J. 275, 3988-3994, 2008.
Adachi N, Kobayashi T, Takahashi H, Kawasaki T, Shirai Y, Ueyama T, Matsuda T, Seki T, Sakai N, and Saito N. Enzymological analysis of mutant protein kinase Cγ causing spinocerebellar ataxia type 14 and its dysfunction in Ca2+ homeostasis. J. Biol. Chem. 283, 19854-19863, 2008.
Sakai N, Terami H, Suzuki S, Haga M, Nomoto K, Tsuchida N, Morohashi KI, Saito N, Asada M, Hashimoto M, Harada D, Asahara H, Ishikawa T, Shimada F, and Sakurada K. Identification of SF-1/Ad4BP gene expression modulators by large scale gain and loss of function studies. J. Endocrinol. 198, 489-497, 2008.
Hozumi Y, Fukaya M, Adachi N, Saito N, Otani K, Kondo K, Watanabe M, and Goto K. Diacylglycerol kinase β accumulates on the perisynaptic site of medium spiny neurons in the striatum. Eur. J. Neurosci. 28, 2409-2422, 2008.
Merino E, Avila-Flores A, Shirai Y, Moraga I, Saito N, and Merida I. Lck-dependent tyrosine phosphorylation of DGKα regulates its membrane association in T cells. J. Immunol. 180, 5805-5815, 2008.
Oyasu M, Fujimiya M, Kashiwagi K, Ohmori S, Imaeda H, and Saito N. Immunogold electron microscopic demonstration of distinct submembranous localization of the activated γPKC depending on the stimulation. J. Histochem. Cytochem. 56, 253-265, 2008.
Ryo C, Yanagita RC, Nakagawa Y, Yamanaka N, Kashiwagi K, Saito N, and Irie K. Synthesis, Conformational Analysis, and Biological Evaluation of 1-Hexyl-indolactam-V10 as a Selective Activator for Novel Protein Kinase C Isozymes. J. Med. Chem. 51, 46-56, 2008.
Ohtani Y, Harada T, Funasaka Y, Nakao Y, Takahara C, M Abdel-Daim, Sakai N, Saito N, Nishigori C, and Aiba A. Metabotropic glutamate receptor subtype-1 is essential for in vivo growth of melanoma. Oncogene, 27, 7162-7170, 2008.
2007
Ueyama T, Tatsuno T, Kawasaki T, Tsujibe S, Shirai Y, Sumimoto H, Leto TL, and Saito N. A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox. Mol. Biol. Cell, 18, 441-454, 2007. doi: 10.1091/mbc.e06-08-0731.
Ueyama T, Lekstrom K, Tsujibe S, Saito N, and Leto TL. Subcellular localization and function of alternatively spliced Noxo1 isoforms. Free Radical Biol. Med. 42, 180-190, 2007. Featured with special commentary.
Shirai Y, Murakami T, Kuramasu M, Iijima L, and Saito N. A novel PIP2 binding of εPKC and its contribution to the neurite induction ability. J. Neurochem. 102, 1635-1644, 2007.
Seki T, Takahashi T, Adachi N, Shimahara T, Abe N, Saito N, and Sakai N. Aggregate Formation of Mutant Protein Kinase C Gamma Found in Spinocerebellar Ataxia Type 14 Impairs Ubiquitin Proteasome System and Induces Endoplasmic Reticulum Stress. Eur. J. Neurosci. 26, 3126-3140, 2007.
2006
Ueyama T, Geiszt M, Leto TL. Involvement of Rac1 in activation of multi-component Nox1 and Nox3-based NADPH oxidases. Mol. Cell. Biol. 26, 2160-2174, 2006. doi: 10.1128/MCB.26. 6, 2160-2174, 2006.
Cheeseman KL, Ueyama T, Michaud T, Kashiwagi K, Wang D, Flax LA, Shirai Y, Loegering DJ, Saito N, and Lennartz MR. Targeting of PKC-ε during FcγR-Dependent Phagocytosis Requires the εC1B domain and Phospholipase C-γ1. Mol. Biol. Cell, 17, 799-813, 2006.
Sato K, Adachi T, Shirai Y, Saito N, and Tomita Y. Local Disassembly of Actin Stress Fibers Induced bySelected Release of Intracellular Tension in Osteoblastic Cell. J. Biomechanical Sci. Engineering. 1, 204-214, 2006.
Yamaguchi Y, Shirai Y, Matsubara T, Kuriyama M, Ohshiro N, Yoshino K, Yonezawa K, Ono Y, and Saito N. Phosphorylation and up-regulation of diacylglycerolkinase γ via its interaction with protein kinase Cγ. J. Biol. Chem. 281, 31627-31637, 2006.
Suzuki Y, Zhang H, Saito S, Kojima I, Urano T, and Mogami H. Glucagon-like peptide 1 activates protein kinase C through Ca2+ dependent activation of phospholipase C in insulin-secreting cells. J. Biol. Chem. 281:28499-28507, 2006.
Shiraishi M, Tanabe A, Saito N, and Sasaki Y. Unphosphorylated MARCKS is involved in neurite initiation induced by insuline-like growth factor-I in SH-SY5Y cells. J. Cell. Physiol. 209:1029-1038, 2006.
Mandadi S, Tominaga T, Numazaki M, Murayama N, Saito N, J Armati P, Roufogalis, B.D., and Tominaga, M. Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCε-mediated phosphorylation at Ser 800. Pain, 123, 106-116, 2006.
Seki T, Irie N, Nakamura K, Sakaue H, Ogawa W, Kasuga M, Yamamoto H, Ohmori S, Saito N, and Sakai N. Fused protein of δPKC activation loop and PDK1-interacting fragment (dAL-PIF) functions as a pseudosubstrate and an inhibitory molecule for PDK1 when expressed in cells. Genes to Cells, 11. 1051-1070, 2006.
Mochizuki H, Seki T, Adachi A, Saito N, Mishima HK, and Sakai N. R659S mutation of γPKC is susceptible to cell death: Implication of this mutation/polymorphism in the pathogenesis of retinitis pigmentosa. Neurochem. Int. 49:669-675, 2006.
Nakagawa Y, Irie K, Yanagita RC, Ohigashi H, Tsuda K, Kashiwagi K, and Saito N. Design and Synthesis of 8-Octyl-benzolactam-V9, a Selective Activator for PKCεη. J. Med. Chem. 49, 2681-2688, 2006.
Matsubara T, Shirai Y, Miyasaka K, Murakami M, Yamaguchi Y, Ueyama T, Kai M, Sakane F, Kanoh H, Hashimoto T, Kamada S, Kikkawa U, and Saito N. Nuclear transportation of diacylglycerol kinase γ and its possible function in the nucleus J. Biol. Chem. 281: 6152-6164, 2006.
Masukawa K, Sakai N, Ohmori S, Shirai Y, and Saito N. Spatiotemporal analysis of the molecular interaction between PICK1 and PKC. ActaHistochem. Cytochem. 39:173-181, 2006.
Taniguchi T, Doe N, Matsuyama S, Kitamura Y, Mori H, Saito N, and Tanaka C. Transgenic mice expressing mutant (N279K) human tau show mutation dependent cognitive deficits without neurofibrillary tangle formation. FEBS Lett. 579, 5704-5712, 2006.
2005
Hayashi S, Ueyama T, Kajimoto T, Yagi K, Kohmura E, and Saito N. Involvement of γPKC in estrogen-induced neuroprotection on focal brain ischemia through G protein-coupled estrogen receptor. J. Neurochem. 93, 883-891, 2005.
Ueyama T, Eto M, Kami K, Tatsuno T, Kobayashi T, Shirai Y, Lennartz MR, Takeya R, Sumimoto H, and Saito N. Isoform-specific Membrane Targeting Mechanism of Rac During FcγR-mediated Phagocytosis. -Positive charge-dependent and independent targeting mechanism of Rac to the phagosome- J. Immunol. 175:2381-2390, 2005.
Adachi N, Oyasu M, Taniguchi T, Yamaguchi Y, Takenaka R, Shirai Y, and Saito N. Immunocytochemical localization of a neuron-specific diacylglycerol kinase β and γ in the developing rat brain. Mol. Brain Res. 139:288-299, 2005.
Abdel-Raheem IT, Hide I, Yanase Y, Shigemoto-Mogami Y, Sakai N, Shirai Y, Saito N, Hamada FM, El-Mahdy, NA, Elsisy AE, Sokar, SS, and Nakata Y. Protein kinase C-α mediates TNF release process in RBL-2H3 mast cells-Running title: αPKC mediates TNF release in RBL-2H3 cells. Br. J. Pharmacol. 145:405-414, 2005.
Taniguchi T, Sumida M, Hiraoka S, Tomoo K, Kakehi T, Minoura K, Sugiyama S, Inaka K, Ishida T, Saito N, and Tanaka C. Effects of different anti-tau antibodies on taufibrillogenesis: RTA-1 and RTA-2 counteract tau aggregation. FEBS Lett. 579, 1399-1404, 2005.
Fukunaga-Takenaka R, Shirai Y, Yagi K, Adachi N, Sakai N, Merino E, Merida I, and Saito N. Importance of chroman ring and tyrosine phosphorylation in the subtype-specific translocation and activation of diacylglycerol kinase α by d-α-tocophenol. Genes to Cells. 10, 311-319, 2005.
Seki T, Matsubayashi H, Amano T, Shirai Y, Saito N, and Sakai N. Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC. Genes to Cells. 10, 225-239, 2005.
Seki T, Adachi N, Ono Y, Mochizuki H, Hiramoto K, Amano T, Matsubayashi H, Matsumoto M, Kawakami H, Saito N, and Sakai N. Mutant protein kinase Cγ found in spinocerebellar ataxia type 14 is susceptible to aggregate and cause cell death. J. Biol. Chem. 280, 29096-29106, 2005.
2004
Ueyama T, Lennartz MR, Noda Y, Kobayashi T, Shirai Y, Rikitake K, Hayashi S, Sakai N, Seguchi H, Sawada M, Sumimoto H, and Saito N. Superoxide (O2-) production at phagosomal cup/phagosome through βI PKC during FcγR-mediated phagocytosis in microglia. J. Immunol. 173, 4582-4589, 2004. doi: 10.4049/jimmunol.173.7.4582.
Bhattacharjee AK, Ueyama T, Kondoh T, Hayashi S, Abouelfetouh A, Sakai N, Saito N, and Kohmura E. In vivo transgene expression using an adenoviral tetracycline-regulated system with neuron-specific enolase promoter. Biochem. Biophys. Res. Commun. 317, 1144-1148, 2004.
Kageyama A, Oka M, Okada T, Nakamura S, Ueyama T, Saito N, Hearing VJ, Ichihashi M, and Nishigori C. Down-regulation of Melanogenesis by Phospholipase D2 through Ubiquitin Proteasome-mediated Degradation of Tyrosinase. J. Biol. Chem. 279, 29774-29780, 2004.
Sakai N, Tsubokawa H, Matsuzaki M, Kajimoto K, Takahashi E, Ren Y, Ohmori S, Shirai Y, Matsubayashi H, Chen J, Duman RS, Kasai H, and Saito N. Propagation of γPKC translocation along the dendrites of Purkinje cell in γPKC-GFP transgenic mice. Genes to Cells 9, 945-957, 2004.
Kuriyama M, Taniguchi T, Shirai Y, Sasaki A, Yoshimura A, and Saito N. Activation and translocation of PKCδ is necessary for VEGF-induced ERK activation through KDR in HEK293T cells. Biochem. Biophys. Res. Commun. 325, 843-851, 2004.
Yagi K. Shirai Y, Hirai M, Sakai N, and Saito N. Phospholipase A2 products retain a neuron specific gisoform of PKC on the plasma membrane through the C1 domain -A molecular mechanism for sustained enzyme activity. Neurochem. Int. 45, 39-47, 2004.
Kajimoto T, Shirai Y, Sakai N, Yamamoto T, Matsuzaki H, Kikkawa U. and Saito N. Ceramide-induced apoptosis mediated by translocation, phosphorylation and activation of protein kinase Cδ at Golgi complex. J. Biol. Chem. 279, 12668-12676, 2004.
Uchino M, Sakai N, Kashiwagi K, Shirai Y, Shinohara Y, Hirose K, Iino M, Yamamura T,and Saito N. Isoform-specific phosphorylation of mGluR5 by PKC blocks Ca2+ oscillation and oscillatory translocation of Ca2+-dependent PKC. J. Biol. Chem. 279, 2254-2261, 2004.
2003
Sakai K, Hasegawa C, Okura M, Morikawa O, Ueyama T, Shirai Y, Sakai N, and Saito N. Novel variants of murine serotonin transporter mRNA and the promoter activity of its upstream sites. Neurosci. Lett. 342, 175-178, 2003.
Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, and Yoshimura A. Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. Nature Cell Biol. 5, 427-432, 2003.
Saito N. Fluorescent imaging of Protein kinase C Translocation. “Protein kinase C Protocols” edited by Newton A.C. Humana Press, pp93-104, 2003.
Fredholm BB, Assender JW, Irenius E, Kodama N, and Saito N. Synergistic effects of adenosine A1 and P2Y receptor stimulation on calcium mobilization and PKC translocation in DDT1 MF-2 cells. Cell. Mol. Neurobiol. 23, 379-400, 2003.
Shindo M, Irie K, Masuda A, Ohigashi H, Shirai Y, Miyasaka K, and Saito N. Synthesis and Phorbol Ester Binding of the Cysteine-rich Domains of DiacylglycerolKinase (DGK) Isozymes: DGKγ and DGKβ are New Targets of Tumor-Promoting Phorbol Esters. J. Biol. Chem. 278, 18448-18454, 2003.
Mogami H, Zhang H, Suzuki Y, Urano T, Saito N, Kojima I, and Petersen OH. Decoding of Short-Lived Ca2+ Influx Signals into Long-Term Substrate Phosphorylation through Activation of Two Distinct Classes of Protein Kinase C. J. Biol. Chem. 278, 9896-9904, 2003.
Salli U, Saito N, and Stormshak F. Spatio-temporal interactions of myristoylatedalanine-rich C kinase substrate (MARCKS) protein with the actin cytoskeleton and exocytosis of oxytocin upon prostaglandin F2α stimulation of bovine lutealcells. Biol. Reprod. 69:2053-2058, 2003.
2002
Larsen EC, Ueyama T, Brannock PM, Shirai Y, Saito N, Larsson C, Loegering D, Weber PB, and Lennartz MR. Role for PKC-ε in FcγR-mediated phagocytosis by RAW 264.7 cells. J. Cell Biol. 159, 939-944, 2002.
Irie N, Sakai N, Ueyama T, Kajimoto T, Shirai Y, and Saito N. Subtype- and species-specific knockdown of PKC using short interfering RNA (siRNA). Biochem. Biophys. Res. Commun. 293, 738-743, 2002.
Saito N, and Shirai Y. Activation Mechanisms of Protein Kinase C: Maturation, Catalytic Activation, and Targeting. J. Biochem. 132, 663-668, 2003.
Shirai Y, and Saito N. Protein Kinase Cγ (PKCγ): Function of Neuron Specific Isotype. J. Biochem. 132, 683-687, 2002.
Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, and Sumimoto H. PAR3β, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions. Biochem. Biophys. Res. Commun. 299, 641-646, 2002.
Tada T, Uchino M, Nagai K, Nomura T, Kondoh T, Saito N, Yamamura T, Yajima Y, and Nishizaki T. The anti-dementia drug FK960 stimulates glial glutamate release via a PKA pathway. Mol. Brain Res. 109, 63-8, 2003.
Irie K, Nakahara A, Nakagawa Y, Ohigashi H, Shindo M, Fukuda H, Konishi H, Kikkawa U, Kashiwagi K, and Saito N. Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity. Pharmacol. Therap. 93, 271-281, 2002.
Zhang X., Kuroda S, Carpenter D, Hu FY, Moats R, Lida K, Nishimura I, Wisner E, Soo C, Beanes S, Dong C, Vastardis H, Kanayama N, Tanizawa T, Saito N, and Ting K. Over-Expression of NELL-1 Induces Premature Cranial Suture Fusion as Seen in Craniosynostosis. J. Clin. Invest. 110, 861-870, 2002.
Goerke Ａ, Sakai N, Gutjahr E, Schlapkohl WA, Mushinski JF, Haller H, Kolch W, Saito N, and Mischak H. Induction of apoptosis by Protein kinase Cδ is independent of its kinase activity. J. Biol. Chem. 277, 32054-32062, 2002.
Ohta K, Nomura T, Kanno T, Nagai K, Yamamoto S, Yajima Y, Kondoh T, Kohmura E, Saito N, and Nishizaki T. L-trans-PDC enhances hippocampal neuronal activity by stimulating glial glutamate release independently of blocking transporters. Biophys. Biochem. Res. Commun. 295, 376-381, 2002.
Nishizaki T, Nagai K, Nomura T, Tada H, Kanno T, Tozaki H, Li XX, Kondoh T, Kodama N, Takahashi E, Sakai N, Tanaka K, and Saito N. A new neuromodulatory pathway with a glial contribution mediated via A2a adenosine receptors. Glia, 39, 133-147, 2002.
Kashiwagi K, Shirai Y, Kuriyama M, Sakai N, and Saito N. Importance of C1B domain for lipid messenger-induced targeting of PKC. J. Biol. Chem. 277, 18037-18045, 2002.
Sakai K, Nakamura M, Sano A, Sakai N, and Saito N. The silencer activity of the novel human serotonin transporter linked polymorphic region. Neurosci. Lett. 327, 13-16, 2002.
Sawano A, Hama H, Saito N, and Miyawaki A. Multiple-colour fluorescence imaging Ca2+-calmodulin, protein kinase C, and their conflicting convergence on a shared target using novel epi-fluorescent microscopy. Biophys. J. 82, 1076-1085, 2002.
Saito N, Kikkawa U, and Nishizuka Y. The family of protein kinase C and membrane lipid mediators. J. Diab. Compl. 16, 1-5, 2002.
2001
Ueyama T, Ren Y, Sakai N, Takahashi M, Ono Y, Kondoh T, Tamaki N, and Saito N. Constitutively active fragment of PKN in microglia/macrophage after middle cerebral artery occlusion in rats. J. Neurochem. 79, 903-913, 2001.
Tozaki H, Kanno T, Nomura T, Kondoh T, Kodama N, Saito N, Aihara H, Nagata T, Matsumoto S, Ohta K, Nagai K, Yajima Y, and Nishizaki T. Role of glial glutamate transporters in the facilitatory action of FK960 on hippocampal neurotransmission. Mol. Brain Res. 97, 7-12, 2001.
Shindo M, Irie K, Ohigashi H, Kuriyama M, and Saito N. Diacylglycerolkinaseg is one of the specific receptors of tumor-promoting phorbol esters. Biochem. Biophys. Res. Commun. 289, 451-456, 2001.
Nakai M, Tanimukai S, Yagi K, Saito N, Taniguchi T, Terashima A, Kawamata T, Yamamoto H, Fukunaga K, Miyamoto E, and Tanaka C. Amyloid β protein activates PKC-δ and induces translocation of myristoylatedalanine-rich C kinase substrate (MARCKS) in microglia. Neurochem. Int. 38, 593-600, 2001.
Mishima K, Otani H, Tanabe T, Kawasaki H, Oshiro A, Saito N, Ogawa R, and Inagaki C. Molecular mechanisms for α2-adrenoceptor-mediated regulation of synoviocytes populations. Jpn. J. Pharmacol. 85, 214-226, 2001.
Saito-Ito A, Yagi K, and Saito N. Distinct distribution of four Ca2+-dependent subtypes of protein kinase C in rat olfactory bulb; definite expression of βII-subtype in the accessory olfactory bulb. Neurochem. Int. 39, 267-274, 2001.
Minami T, Hara K, Oshiro N, Ueoku S, Yoshino K-I, Tokunaga C, Shirai Y, Saito N, Gout I, and Yonezawa K. Distinct regulatory mechanism for p70 S6 kinaseβ from that for p70 S6 kinaseα. Genes to Cells. 6, 1003-1015, 2001.
Kajimoto T, Ohmori S, Shirai Y, Sakai N, and Saito N. Subtype-specific translocation of the δ subtype of protein kinase C and its activation by tyrosine phosphorylation induced by ceramide in HeLa cells. Mol. Cell. Biol. 21, 1769-1783, 2001.
2000
Ueyama T, Ren Y, Ohmori S, Sakai K, Tamaki N, and Saito N. cDNA cloning of an alternative splicing variant of protein kinase Cδ (PKCδIII), a new truncated form of PKCδ, in rats. Biochem. Biophys. Res. Commun. 269, 557-563, 2000.
Ohmori S, Sakai N, Shirai Y, Yamamoto H, Miyamoto E, Shimizu N, and Saito N. Importance of PKC targeting for the phosphorylation of its substrate, myristoylatedalanine-rich C-kinase substrate MARCKS). J. Biol. Chem. 275, 26449-26457, 2000.
Shirai Y, Segawa S, Kuriyama M, Goto K, Sakai N, and Saito N. Subtype-specific translocation of diacylglycerol kinase and and its correlation with protein kinase C. J. Biol. Chem. 275, 24760-24766, 2000.
Shirai Y, Kashiwagi K, Sakai N, and Saito N. Phospholipase A2 and its products are involved in the purinergic receptor-mediated translocation of protein kinase C in CHO-K1 cells. J. Cell Sci. 113, 1335-1343, 2000.
Sumioka K, Shirai Y, Sakai N, Hashimoto T, Tanaka C, Yamamoto M, Takahashi M, Ono Y, and Saito N. Induction of 55 kDa PKN cleavage product by ischemia/reperfusion model in the rat retina. Invest. Opthal. Vis. Sci. 41, 29-35, 2000.
Sakai N, Kodama N, Ohmori S, Sasaki K, and Saito N. Involvement of the actin cytoskeleton in the regulationof serotonin transporter (SET) activity: possible mechanism underlying SET regulation by protein kinase C. Neurochem. Int. 36, 567-579, 2000.
Oyasu M, Kuroda S, Nakashita M, Fujimiya M, Kikkawa U, and Saito N. Immunocytochemical localization of a neuron-specific thrombospondin-1-like protein, NELL2: Light and electron microscopic studies in the rat brain. Mol. Brain Res. 76, 151-160, 2000.
Yokogawa T, Nagata S, Nishio Y, Tsutsumi T, Ihara S, Shirai R, Morita K, Umeda M, Shirai Y, Saito N, and Fukui Y. Evidence that 3’-phosphorylated polyphosphoinositides are generated at the nuclear surface: use of immunostaining technique with monoclonal antibodies specific for PI 3,4-P2, FEBS Lett. 473 473, 222-226, 2000.
Akiyama H, Kondoh T, Kokunai T, Nagashima T, Saito N, and Tamaki N. Blood-brain barrier formation of grafted human umbilical vein endothelial cells in athymic mouse brain. Brain Res. 858, 172-176, 2000.
Larsen EC, DiGennaro JA, Saito N, Mehta S, Loegering DJ, Mazurkiewicz JE, and Lennartz MR. Differential requirement for classic and novel PKC isoforms in respiratory burst and phagocytosis in RAW 264.7 cells. J. Immunol. 165, 2809-2817, 2000.
Nakagawa N, Hoshijima M, Oyasu M, Saito N, Tanizawa K, and Kuroda S. ENH, containing PDZ andLIM domain, heart/skeletal muscle-specific protein, associates with cytoskeletal protein through its PDZ domain. Biochem. Biophys. Res. Commun. 272, 505-512, 2000.
Shibaguchi H, Takemura K, Kan S, Kataoka Y, Kaibara M, Saito N, and Taniyama K. Role of synaptophysin in exocytic release of dopamine from Xenopusoocytes injected with rat brain mRNA. Cell. Mol. Neurobiol. 20, 401-408, 2000.
Kondoh T, Motooka Y, Bhattacharjee AK, Kokunai T, Saito N, and Tamaki N. In vivo gene transfer into periventricular region by electroporation. Neurologia medico-chirurgica. 40, 618-623, 2000.
Tanii H, Zang XP, Saito N, and Saijoh K. Involvement of GABA neurons in allylnitrile-induced dyskinesia. Brain Res. 887, 454-459, 2000.
1999
Nakai M, Hojo K, Yagi K, Saito N, Taniguchi T, Terashima A, Kawamata T, Hashimoto T, Maeda K, Gescwendt M, Yamamoto H, Miyamoto E, and Tanaka C. Amyloid β Protein (25-35) Phosphorylates MARCKS through Tyrosine Kinase-Activated Protein Kinase C Signaling Pathway in Microglia. J. Neurochem. 72, 1179-1186, 1999.
Murakami N, Kitamura N, Kajimoto Y, Hashimoto T, Yasuda M, Maeda K, Sakai N, Shirakawa O, Nishino N, Tanaka C, and Saito N. An association study of a polymorphism of non-erythroida-spectrin gene with schizophrenia. Am. J. Med. Genet. 88, 291-293, 1999.
Takaishi H, Konishi H, Matsuzaki H, Ono Y, Shirai Y, Saito N, Kitamura T, Ogawa W, Kasuga M, Kikkawa U, and Nishizuka Y. Regulation of nuclear translocation of Forkhead transcription factor AFX by protein kinase B. Proc. Natl. Acad. Sci., USA. 96, 11836-11841, 1999.
Kuroda S, Oyasu M, Kawakami M, Kanayama KN, Tanizawa K, Saito N, Abe T, Matsuhashi S, and Ting K. Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins, NELL1 and NELL2. Biochem. Biophys. Res. Commun. 265, 79-86, 1999.
Ren Y, Shimada K, Shirai Y, Fujimiya M, and Saito N. Immunocytochemical localization of serotonin and serotonin transporter (SET) in taste buds of rat. Mol. Brain Res. 74, 221-224, 1999.
Shimada F, Shiga Y, Morikawa M, Kawazura H, Morikawa O, Matsuoka T, Nishizaki T, and Saito N. Theneuroprotective agent MS-153 stimulates glutamate uptake. Eur. J. Pharmacol. 386, 263-270, 1999.
1998
Hashimoto T, Kawamata T, Saito N, Sasaki M, Nakai M, Niu S, Taniguchi T, Terashima A, Yasuda M, Maeda K, and Tanaka C. Isoform-specific redistribution of calcineurin Aα and Aβ in hippocampal CA1 region of Gerbil after transient ischemia. J. Neurochem. 70, 1289-1298, 1998.
Morikawa O, Sakai N, Obara H, and Saito N. Effects of interferon-α and -γ on the transcriptional regulation of serotonin transporter. Eur. J. Pharmacol. 349, 317-324, 1998.
Ohmori S, Shirai Y, Sakai N, Fujii M, Konishi H, Kikkawa U, and Saito N. Three distinct mechanisms for translocation and activation of δ-subspecies of protein kinase C. Mol. Cell. Biol. 18, 5263-5271, 1998.
Shirai Y, Kashiwagi K, Yagi K, Sakai N, and Saito N. Distinct effects of fatty acids on translocation of γ- and ε- protein kinase C. J. Cell Biol. 143, 511-521, 1998.
Yamamoto H, Fujimiya M, Shirai Y, Nakashita M, Oyasu M, and Saito N. Immunohistochemical localization of serotonin transporter in normal and colchicine treated rat brain. Neurosci. Res. 32, 305-312, 1998.
Shirai Y, and Saito N. Subspecies specific targeting mechanism of protein kinase C. Jpn. J. Pharmacol. 78, 411-417, 1998.
1997
Sakai N, Sasaki K, Ikegaki N, Shirai Y, and Saito N. Direct visualization of translocation of γ-subspecies of protein kinase C in living cells using fusion proteins with green fluorescent protein. J. Cell Biol. 139:1465-1476, 1997.
Sakai N, Sasaki K, Nakashita M, Honda S, Ikegaki N, and Saito N. Modulation of serotonin transporter activity by a PKC activator and an inhibitor of type 1 and 2A serine/threonine phophatases. J. Neurochem. 68, 2618-2624, 1997.
Obata H, Shimada K, Sakai N, and Saito N. GABAergic neurotransmission in rat taste buds; Immunocytochemical study for GABA and GABA transporter subtypes. Mol. Brain Res. 49 29-36, 1997.
Nakashita M, Sasaki K, Sakai N, and Saito N. Effects of tricyclic and tetracyclic antidepressants on the three subtypes of GABA transporter. Neurosci. Res. 29; 87-91, 1997.
Nishimura M, Sato K, Mizuno M, Yoshiya I, Shimada S, Saito N, and Tohyama M. Differential expression patterns of GABA transporters (GAT1-3) in the rat olfactory bulb. Mol. Brain Res. 45, 268-274, 1997.
1996
Itouji A, Sakai N, Tanaka C, and Saito N. Neuronal and glial localization of two GABA transporters (GAT1 and GAT3) in the rat cerebellum. Mol. Brain Res. 37:309-316, 1996.
Koga T, Sakai N, Tanaka C, and Saito N. Presynaptic and Ca2+-independent PKC subspecies modulates NMDAR1 current. NeuroReport 7: 477-480, 1996.
Satsuma H, Saito N, Hamanishi C, Hashima M, and Tanaka S. α and ε isozymes of protein kinase C in the chondrocytes in normal and early osteoarthriticarticular cartilage. Calcified Tissue International. 58: 192-194, 1996.
Oka M, Ogita K, Ando H, Horikawa T, Hayashibe K, Saito N, Kikkawa U, and Ichihashi M. Deletion of specific protein kinase C subspecies in human melanoma cells. J. Cellular Physiol. 167: 406-412, 1996.
Shirai Y, Shirakawa O, Nishino N, Saito N, and Nakai H. Increased striatal glutamate transporter by repeated intermittent administration of methamphetamine. Psychiatry and Clinical Neuroscience, 50, 161-164, 1996.
Tanaka C, Kawamata T, Hashimoto T, Sasaki M, and Saito N. Isoform-specific involvement of calcineurin in neuronal death of a gerbil model of brain ischemia and in Alzheimer disease pathology. IN.; Integrative and Molecular Approach to Brain Function. (M/. Ito andf Y. Miyasaka, eds). Elsevier Science B.V. Tokyo pp 57-65, 1996.
1995
Honda S, Yamamoto M, and Saito N. Immunocytochemical localization of three subtypes of GABA transporter in rat retina. Mol. Brain Res. 33: 319-325, 1995.
Saijoh K, Saito N, Lee MJ, Fujii M, Kobayashi T, and Sumino K. Molecular cloning of cDNA encoding a bovine selenoprotein P-like protein containing 12 selenocysteines and a (His-Pro) rich domain insertion, and its regional expression. Mol. Brain Research. 30: 301-311, 1995.
Saito N, and Tanaka C. Functional regulation of GABA transporters by PKC and their distinct localization. In GABA:Receptors, transporters and metabolism (C. Tanaka and N.G. Bowery eds), Birkhauser, Basel, Switzerland, 1995.
1994
Fukuda K, Saito N, Yamamoto M, and Tanaka C. Immunocytochemical localization of α-, βI-, βII- and γ-subspecies of protein kinase C in the monkey visual pathway. Brain Res. 658: 155-162, 1994.
Ikegaki N, Saito N, Hashima M, and Tanaka C. Production of specific antibodies against GABA transporter subtypes (GAT1, GAT2, GAT3) and their application to immunocytochemistry. Mol. Brain Res. 26: 47-54, 1994.
Murakami N, Sakai N, Nei K, Matsuyama S, Saito N, and Tanaka C. A phosphatase inhibitor induces long-lasting potentiation of synaptic transmission in the hippocampal CA1 region. Neurosci. Lett. 176: 181-184, 1994.
Osawa I, Saito N, Koga T, and Tanaka C. Phorbol ester-induced inhibition of GABA uptake by synaptosomes and by Xenopusoocyte expressing GABA transporter (GAT1). Neurosci. Res. 19: 287-293, 1994.
Saito N, Tsujino T, Fukuda K, and Tanaka C. α-, βII- and γ-subspecies of protein kinase C localized in the monkey hippocampus; pre and postsynaptic localization of g-subspecies. Brain Res. 656: 245-256, 1994.
